Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis
Abstract
Objectives We aimed to identify soluble biomarkers that differentiate psoriatic arthritis (PsA) from osteoarthritis (OA).Methods Markers of cartilage metabolism (cartilage oligomeric matrix protein [COMP], hyaluronan), metabolic syndrome (adiponectin, adipsin, resistin, hepatocyte growth factor [HGF], insulin, leptin) and inflammation (C-reactive protein [CRP], interleukin-1β [IL-1β], IL-6, IL-8, tumour necrosis factor alpha [TNFα], monocyte chemoattractant protein-1 [MCP-1], nerve growth factor [NGF]) were compared in serum samples from 201 patients with OA, 77 patients with PsA and 76 controls. Levels across the groups were compared using the Kruskal-Wallis test. Pairwise comparisons were made with Wilcoxon rank-sum test. Multivariate logistic regression analyses were performed to identify markers that differentiate PsA from OA. Receiver operating characteristic (ROC) curves were constructed based on multivariate models. The final model was further validated in an independent set of 73 PsA and 75 OA samples using predicted probabilities calculated with coefficients of age, sex and biomarkers.Results Levels of the following markers were significantly different across the three groups (p<0.001)-COMP, hyaluronan, resistin, HGF, insulin, leptin, CRP, IL-6, IL-8, TNFα, MCP-1, NGF. In multivariate analysis, COMP (OR 1.24, 95% CI 1.06 to 1.46), resistin (OR 1.26, 95% CI 1.07 to 1.48), MCP-1 (OR 1.10, 95% CI 0.07 to 1.48) and NGF (OR<0.001, 95% CI <0.001 to 0.25) were found to be independently associated with PsA versus OA. The area under the ROC curve (AUROC) for this model was 0.99 compared with model with only age and sex (AUROC 0.87, p<0.001). Similar results were obtained using the validation sample.Conclusion A panel of four biomarkers may distinguish PsA from OA. These results need further validation in prospective studies.
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CFD is involved in pathophysiological mechanisms of osteoarthritis and is considered a potential predictive biomarker of joint pain in patients with hip and knee osteoarthritis.
“In line with this finding, patients’ cells also showed increased mRNA levels of complement factor D (CFD), a component of the alternative complement pathway [147], which is involved in pathophysiological mechanisms of osteoarthritis and is considered as a potential predictive biomarker of joint pain in patients with hip and knee osteoarthritis [148,149,150].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [150]
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- Authors
- Chandran, V., Abji, F., Perruccio, A. V., Gandhi, R., Li, S., Cook, R. J., & Gladman, D. D.
- Affiliations
- University of Toronto (CA)
- University Health Network (CA)
- Toronto Western Hospital (CA)
- University of Waterloo (CA)
- Corresponding author
- Gladman, Dafna D
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 78
- Issue
- 6
- Pages
- 796-801
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2942307919
- Cited by
- 48
- References
- 39
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 3
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Keywords
- psoriatic arthritis, osteoarthritis, serum biomarkers, differential diagnosis, cartilage oligomeric matrix protein, hyaluronic acid, resistin, hepatocyte growth factor, nerve growth factor, MCP-1, inflammatory cytokines, metabolic syndrome, C-reactive protein, biomarker panel, disease classification, diagnostic accuracy, leptin, adiponectin
- MeSH terms
- Adult, Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Osteoarthritis, ROC Curve, Severity of Illness Index, Solubility, Reproducibility of Results, Biomarkers, Arthritis, Psoriatic, Chemokine CCL2, Nerve Growth Factor, Resistin, Cartilage Oligomeric Matrix Protein
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