Serum Biomarkers of Inflammation and Turnover of Joint Cartilage Can Help Differentiate Psoriatic Arthritis (PsA) Patients from Osteoarthritis (OA) Patients
Open accessAbstract
The aim of this study was to find characteristic biomarkers in the serum of patients with osteoarthritis (OA) and psoriatic arthritis (PsA) responsible for inflammation and destruction of joint cartilage, which could differentiate these two diseases. The study included 67 people: 22 patients with knee OA, 22 patients with PsA, and 23 individuals who were the control group of healthy individuals (HC). The concentration of IL-18, IL-20, IL-6, MMP-1, MMP-3, COMP, PG-AG, and YKL-40 in serum were determined. Among the OA and PsA patients group, the radiological assessment and clinical assessment were also performed. The concentration of 7 out of 8 of examined biomarkers (except MMP-1) was statistically significantly higher in the serum of patients with OA and PsA than in the control group. Compering OA and PsA groups only, the serum PG-AG level in OA patients was statistically significantly higher than in PsA patients (p < 0.001). The results of univariate and multivariate logistic regression analysis comparing OA and PsA biomarker serum levels identified PG-AG and COMP as markers that are significantly different between patients with OA and PsA (odds ratio 0.995 and 1.003, respectively). The ROC curve constructed using the model with age showed PG-AG and COMP had an AUC of 0.907. The results of this study show that COMP and PG-AG may be sensitive markers differentiating patients with osteoarthiritis from psoriatic arthritis.
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Rapid biomarker assays targeting inflammatory markers such as IL-1β, TNF-α, and IL-6 and indicators of cartilage degradation are being developed.
“Targeting inflammatory markers like IL-1β, TNF-α, and IL-6 as well as indicators of cartilage degradation, rapid biomarker assays—such as lateral flow tests using antibody-coated nanoparticles (yielding results in 10–20 min with nanogram-range sensitivity), microfluidic lab-on-a-chip platforms (employing colorimetric, fluorescent, or electrochemical readouts), and multiplexed biosensors with”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [134]
The Introduction and Methods §2.3 identify IL-6 and markers of cartilage turnover and report measuring them with ELISA kits. They do not support the claim that rapid assays are being developed, nor do they identify IL-1β or TNF-α as targets; the described methods are not the lateral-flow, microfluidic, or multiplexed devices in the citing sentence. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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Self-citation
- Authors
- Waszczykowski, M., Fabiś-Strobin, A., Bednarski, I., Lesiak, A., Narbutt, J., & Fabiś, J.
- Affiliations
- Medical University of Lodz (PL)
- Polish Mother’s Memorial Hospital Research Institute (PL)
- Corresponding author
- Waszczykowski, Michał
- ORCID
- Venue
- Diagnostics
- Publisher
- MDPI AG
- Published
- 2020-12-31
- Volume
- 11
- Issue
- 1
- Pages
- 52
- ISSN
- 2075-4418 (ISSN-L)
- PMC
- PMC7824573
- OpenAlex
- W3113498042
- Cited by
- 9
- References
- 48
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 5 · 2021: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diagnostics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Uniwersytet Medyczny w Lodzi (502-03/7-048-02/502-54-006;, 503/1-040-02/503-51-001-17;)
- Topics
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- psoriatic arthritis, osteoarthritis, serum biomarkers, differential diagnosis, cartilage turnover, joint inflammation, prostaglandin E2, YKL-40, IL-18, IL-20, interleukin-6, matrix metalloproteinases, knee osteoarthritis
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