Non-specific effects of vaccines: plausible and potentially important, but implications uncertain

Sex differences in immune responses

Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370

Trained immunity: A program of innate immune memory in health and– disease

Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

Querec, T. D., Akondy, R. S., Lee, E. K., Cao, W., Nakaya, H. I., Teuwen, D. E., Pirani, A. M., Gernert, K. M., Deng, J., Marzolf, B., et al. (2008) · Nature Immunology · doi:10.1038/ni.1688 · Cited by 1,123

THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE

Mackaness, G. B. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.1.105 · Cited by 806

Herpesvirus latency confers symbiotic protection from bacterial infection

Barton, E. S., White, D. W., Cathelyn, J. S., Brett-McClellan, K. A., Engle, M., Diamond, M. S., Miller, V. L., & Virgin, H. W. (2007) · Nature · doi:10.1038/nature05762 · Cited by 763

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

Higgins, J. P. T., Soares‐Weiser, K., López-López, J. A., Κακούρου, Α., Chaplin, K., Christensen, H., Martin, N. K., Sterne, J. A. C., & Reingold, A. L. (2016) · BMJ · doi:10.1136/bmj.i5170 · Cited by 635

Sex-based differences in immune function and responses to vaccination

Klein, S. L., Marriott, I., & Fish, E. N. (2015) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/tru167 · Cited by 564

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Jacobs, C., Xavier, R. J., van der Meer, J. W. M., van Crevel, R., & Netea, M. G. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.10.005 · Cited by 473

Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality

Mina, M. J., Metcalf, C. J. E., de Swart, R. L., Osterhaus, A. D. M. E., & Grenfell, B. T. (2015) · Science · doi:10.1126/science.aaa3662 · Cited by 421

Evidence for macrophage-mediated protection against lethal Candida albicans infection

Bistoni, F., Vecchiarelli, A., Cenci, E., Puccetti, P., Marconi, P., & Cassone, A. (1986) · Infection and Immunity · doi:10.1128/iai.51.2.668-674.1986 · Cited by 285

Harnessing the beneficial heterologous effects of vaccination

Goodridge, H. S., Ahmed, S., Curtis, N. C., Kollmann, T. R., Levy, O., Netea, M. G., Pollard, A. J., van Crevel, R., & Wilson, C. B. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.43 · Cited by 260

Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis

de Castro, M. J., Pardo‐Seco, J., & Martinón‐Torres, F. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ144 · Cited by 209

Influence of BCG vaccine strain on the immune response and protection against tuberculosis

Ritz, N., Hanekom, W. A., Robins-Browne, R. M., Britton, W. J., & Curtis, N. C. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00118.x · Cited by 201

The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial

Lund, N., Andersen, A., Hansen, A. S., Jepsen, F. S., Barbosa, A., Biering-Sørensen, S. R., Rodrigues, A., Ravn, H., Aaby, P., & Benn, C. S. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ617 · Cited by 185

The non-specific effects of vaccines

Shann, F. A. (2010) · Archives of Disease in Childhood · doi:10.1136/adc.2009.157537 · Cited by 121

Acute Lower Respiratory Infection Among Bacille Calmette-Guérin (BCG)–Vaccinated Children

Hollm-Delgado, M.-G., Stuart, E. A., & Black, R. E. (2013) · PEDIATRICS · doi:10.1542/peds.2013-2218 · Cited by 110

Nonspecific Effects of Vaccines

Goldblatt, D., & Miller, E. (2014) · JAMA · doi:10.1001/jama.2014.471 · Cited by 104

Non-specific immunological effects of selected routine childhood immunisations: systematic review

Kandasamy, R., Voysey, M., McQuaid, F., de Nie, K., Ryan, R., Orr, O. E., Uhlig, U., Sande, C., O’Connor, D., & Pollard, A. J. (2016) · BMJ · doi:10.1136/bmj.i5225 · Cited by 96

Effect of vaccination programmes on mortality burden among children and young adults in the Netherlands during the 20th century: a historical analysis

van Wijhe, M., McDonald, S., de Melker, H. E., Postma, M. J., & Wallinga, J. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00027-x · Cited by 95

The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda

Anderson, E. J., Webb, E. L., Mawa, P. A., Kizza, M., Lyadda, N., Nampijja, M., & Elliott, A. M. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.053 · Cited by 92

Vaccine Preventable Deaths and the Global Immunization Vision and Strategy, 2006-2015

(2006) · JAMA · doi:10.1001/jama.295.24.2840 · Cited by 75

[Effect of Bacillus Callmette Guerin (BCG) on the receptivity of nude mice to Schistosoma mansoni].

Tribouley, J., Tribouley-Duret, J., & Appriou, M. (1978) · PubMed · Cited by 74

BCG vaccination at birth and early childhood hospitalisation: a randomised clinical multicentre trial

Stensballe, L. G., Sørup, S., Aaby, P., Benn, C. S., Greisen, G. O., Jeppesen, D. L., Birk, N. M., Kjærgaard, J., Nissen, T. N., Pihl, G. T., et al. (2016) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-310760 · Cited by 65

Molecular Analysis of Non-Specific Protection against Murine Malaria Induced by BCG Vaccination

Parra, M., Liu, X., Derrick, S. C., Yang, A., Tian, J., Kolibab, K., Kumar, S., & Morris, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066115 · Cited by 64

The WHO Review of the Possible Nonspecific Effects of Diphtheria-Tetanus-Pertussis Vaccine

Aaby, P., Ravn, H., & Benn, C. S. (2016) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001269 · Cited by 55

Nonspecific effect of BCG vaccination at birth on early childhood infections: a randomized, clinical multicenter trial

Kjærgaard, J., Birk, N. M., Nissen, T. N., Thøstesen, L. M., Pihl, G. T., Benn, C. S., Jeppesen, D. L., Pryds, O. A., Kofoed, P., Aaby, P., et al. (2016) · Pediatric Research · doi:10.1038/pr.2016.142 · Cited by 55

Epidemiological studies of the non‐specific effects of vaccines: II – methodological issues in the design and analysis of cohort studies

Farrington, P., Firth, M. J., Moulton, L. H., Ravn, H., Andersen, P. K., Evans, S. J. W., & on behalf of the Working Group on Non‐specific Effects of Vaccines (2009) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2009.02302.x · Cited by 48

Sex-dependent immune responses to infant vaccination: an individual participant data meta-analysis of antibody and memory B cells

Voysey, M., Barker, C. I. S., Snape, M. D., Kelly, D. F., Trück, J., & Pollard, A. J. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.036 · Cited by 46

The Nonspecific Effects of Vaccines and the Expanded Program on Immunization

Shann, F. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir244 · Cited by 41

BCG-associated heterologous immunity, a historical perspective: experimental models and immunological mechanisms

Freyne, B., Marchant, A., & Curtis, N. C. (2015) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/tru196 · Cited by 39

Could the RTS,S/AS01 meningitis safety signal really be a protective effect of rabies vaccine?

Gessner, B. D., Knobel, D. L., Conan, A., & Finn, A. H. R. (2017) · Vaccine · doi:10.1016/j.vaccine.2016.12.067 · Cited by 28

CNS infection safety signal of RTS,S/AS01 and possible association with rabies vaccine

Gessner, B. D., Wraith, D. C., & Finn, A. H. R. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30081-2 · Cited by 10

Assessing sex-differences and the effect of timing of vaccination on immunogenicity, reactogenicity and efficacy of vaccines in young children: study protocol for an individual participant data meta-analysis of randomised controlled trials

Voysey, M., Pollard, A. J., Perera, R., & Fanshawe, T. R. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011680 · Cited by 10

A guide to vaccinology: from basic principles to new developments

Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

Zimmermann, P., & Curtis, N. C. (2020) · Archives of Disease in Childhood · doi:10.1136/archdischild-2020-320338 · Cited by 513

Considering BCG vaccination to reduce the impact of COVID-19

Curtis, N. C., Sparrow, A., Ghebreyesus, T. A., & Netea, M. G. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31025-4 · Cited by 346

Vaccines for COVID-19: The current state of play

Koirala, A., Joo, Y. J., Khatami, A., Chiu, C., & Britton, P. N. (2020) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2020.06.010 · Cited by 244

Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations

Kühtreiber, W. M., Tran, L., Kim, T., Dybala, M. P., Nguyen, B., Plager, S., Huang, D., JANES, S. E., DEFUSCO, A. A., Baum, D., et al. (2018) · npj Vaccines · doi:10.1038/s41541-018-0062-8 · Cited by 179

Heterologous vaccine effects

Saadatian‐Elahi, M., Aaby, P., Shann, F. A., Netea, M. G., Levy, O., Louis, J. A., Picot, V., Greenberg, M. E., & Warren, W. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.06.020 · Cited by 43

The Yin and Yang of the Non-Specific Effects of Vaccines

Cose, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.08.008

Unravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists

Jensen, K. J., Benn, C. S., & van Crevel, R. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.05.005 · Cited by 45

Non-specific and sex-differential effects of routine vaccines: What evidence is needed to take these effects into consideration in low-income countries?

Aaby, P., & Benn, C. S. (2011) · Human Vaccines · doi:10.4161/hv.7.1.13848 · Cited by 29

Sex differences in the vaccine-specific and non-targeted effects of vaccines

Flanagan, K. L., Klein, S. L., Skakkebæk, N. E., Marriott, I., Marchant, A., Selin, L. K., Fish, E. N., Prentice, A. M., Whittle, H. C., & Benn, C. S. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.01.071 · Cited by 62