Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality
Open accessAbstract
Extra dividends from measles vaccine: Vaccination against measles has many benefits, not only lifelong protection against this potentially serious virus. Mina et al. analyzed data collected since mass vaccination began in high-income countries when measles was common. Measles vaccination is associated with less mortality from other childhood infections. Measles is known to cause transient immunosuppression, but close inspection of the mortality data suggests that it disables immune memory for 2 to 3 years. Vaccination thus does more than safeguard children against measles; it also stops other infections taking advantage of measles-induced immune damage. Science , this issue p. 694
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Recent studies have indicated that measles disease casts a prolonged shadow over the immune system, with depletion of existing immune memory, such that children who have had the disease have an increased risk of death from other causes over the next few years.
“recent studies have indicated that measles disease casts a prolonged ‘shadow’ over the immune system, with depletion of existing immune memory, such that children who have had the disease have an increased risk of death from other causes over the next few years67,68.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [68]
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- Authors
- Mina, M. J., Metcalf, C. J. E., de Swart, R. L., Osterhaus, A. D. M. E., & Grenfell, B. T.
- Affiliations
- Emory University (US)
- National Institutes of Health (US)
- Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.
- Erasmus MC (NL)
- Corresponding author
- Mina, Michael J.
- Venue
- Science
- Published
- 2015-05-08
- Volume
- 348
- Issue
- 6235
- Pages
- 694-699
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4823017
- OpenAlex
- W1725195596
- Cited by
- 421
- References
- 43
- Citations by year
- 2026: 37 · 2025: 37 · 2024: 26 · 2023: 41 · 2022: 34 · 2021: 33 · 2020: 57 · 2019: 42 · 2018: 36 · 2017: 34 · 2016: 26 · 2015: 18
- FWCI
- 29.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- Fogarty International Center
- Bill and Melinda Gates Foundation
- Science and Technology Directorate of the Department of Homeland Security (HSHQDC-12-C-00058)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- measles, immunosuppression, immunomodulation, measles vaccination, herd immunity, high-income countries
- MeSH terms
- B-Lymphocytes, Child, Child, Preschool, England, Female, Humans, Immunologic Memory, Lymphocyte Depletion, Male, Measles, Measles Vaccine, Opportunistic Infections, T-Lymphocytes, Time Factors, United States, Vaccination, Wales, Incidence, Child Mortality, Immunomodulation
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