Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice

Moore, R A; Moore, O A; Derry, S; Peloso, P M; Gammaitoni, A R; Wang, H

doi:10.1136/ard.2009.107805

Cited by 279Statistical Methods in Clinical TrialsMeta-analysis and systematic reviewsMusculoskeletal pain and rehabilitation

Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice

Open access

Moore, R A, Moore, O A, Derry, S, Peloso, P M, Gammaitoni, A R, Wang, H·2010·Annals of the Rheumatic Diseases

DOI 10.1136/ard.2009.107805PMC PMC2800200

Open this paper in CoChat — free account Open PDF

Abstract

Though long-term exposure to nicotine is highly addictive, one "beneficial" consequence of chronic tobacco use is a reduced risk for Parkinson9s disease. Interestingly, these effects both reflect structural and functional plasticity of brain circuits controlling reward and motor behavior, and specifically recruitment of nicotinic acetylcholine receptors (nAChR) in mesencephalic dopaminergic neurons. Since the underlying cellular mechanisms are poorly understood, we addressed this issue employing primary cultures of mouse mesencephalic dopaminergic neurons. Exposure to nicotine (1-10 μM) for 72 hr in vitro increased dendritic arborization and soma size in primary cultures. These effects were blocked by mecamylamine and dihydro-β-erythroidine, but not methyllycaconitine. The involvement of α4β2 nAChR was supported by the lack of nicotine-induced structural remodeling in neurons from α4 null mutant mice (KO). Challenge with nicotine triggered phosphorylation of the extracellular signal-regulated kinase (ERK) and the thymoma viral proto-oncogene (Akt) followed by activation of the mTORC1-dependent p70 ribosomal S6 protein kinase. Upstream pathway blockade using the phosphatidylinositol 3-kinase inhibitor LY294002 resulted in suppression of nicotine-induced phosphorylations and structural plasticity. These effects were dependent upon functional DA D3 receptor (D3R) since nicotine was inactive both in cultures from D3R KO mice and following pharmacologic blockade with D3R antagonist SB-277011-A (50 nM). Finally, exposure to nicotine in utero (5 mg/kg/day for 5 days) resulted in increased soma area of DAergic neurons of newborn mice, effects not observed in D3KO mice. These findings indicate that nicotine-induced structural plasticity in mesencephalic dopaminergic neurons involves α4β2 nAChRs together with dopamine D3R-mediated recruitment of ERK/Akt-mTORC1 signaling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/ard.2009.107805

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The overview planned to compare only like with like, such as study duration, because insufficient length can be an additional source of bias.
“We planned to compare only like with like (where possible); for example in study duration, which can be an additional source of bias if insufficient in length (Moore 2010).”
From Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews (2017) · cites this paper as Moore 2010
Small studies of fewer than 100 participants per arm are at increased risk of random effects in estimating both the direction and magnitude of treatment effects.
“small studies of fewer than 100 participants per arm (Moore 2010; Nüesch 2010) are at increased risk of succumbing to the random effects in estimating both direction and magnitude of treatment effects”
From Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews (2017) · cites this paper as Moore 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations
Dworkin, R. H., Turk, D. C., Wyrwich, K. W., Beaton, D., Cleeland, C. S., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Kerns, R. D., Ader, D. N., et al. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.005 · Cited by 3,471 · see citing works
The number needed to treat: a clinically useful measure of treatment effect
Cook, R. J., & Sackett, D. L. (1995) · BMJ · doi:10.1136/bmj.310.6977.452 · Cited by 1,885 · see citing works
Algorithm for neuropathic pain treatment: An evidence based proposal
Finnerup, N. B., Otto, M., McQuay, H. J., Jensen, T. S., & Sindrup, S. H. (2005) · Pain · doi:10.1016/j.pain.2005.08.013 · Cited by 1,325 · see citing works
Statistics with Confidence: Confidence Intervals and Statistical Guidelines.
JOLLIFFE, F. R., Gardner, M. J., & Altman, D. G. (1990) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.2307/2982808 · Cited by 1,319 · see citing works
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Baliki, M. N., Geha, P., Apkarian, A. V., & Chialvo, D. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4123-07.2008 · Cited by 852 · see citing works
Statistics in Medicine: Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates
Morris, J., & Gardner, M. J. (1988) · BMJ · doi:10.1136/bmj.296.6632.1313 · Cited by 764 · see citing works
Impact of covert duplicate publication on meta-analysis: a case study
Tramèr, M. R., Reynolds, D. J. M., Moore, R. A., & McQuay, H. J. (1997) · BMJ · doi:10.1136/bmj.315.7109.635 · Cited by 702 · see citing works
Self-citation
Size is everything – large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects
Moore, R. A., Gavaghan, D. J., Tramèr, M. R., Collins, S., & McQuay, J. H. (1998) · Pain · doi:10.1016/s0304-3959(98)00140-7 · Cited by 607 · see citing works
Self-citation
Using Numerical Results from Systematic Reviews in Clinical Practice
McQuay, H. J., & Moore, R. A. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-9-199705010-00007 · Cited by 452 · see citing works
Self-citation
Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials
Sultan, A., Gaskell, H., Derry, S., & Moore, R. A. (2008) · BMC Neurology · doi:10.1186/1471-2377-8-29 · Cited by 292 · see citing works
Self-citation
Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria.
Pham, T., van der Heijde, D. M. F. M., Lassere, M. N., Altman, R. D., Anderson, J. J., Bellamy, N., Hochberg, M. C., Simon, L. S., Strand, V., WOODWORTH, T. G., et al. (2003) · PubMed · Cited by 261 · see citing works
Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden
Geborek, P., Kapetanovic, M. C., Petersson, I. F., & Saxne, T. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.9.793 · Cited by 253 · see citing works
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent‐onset rheumatoid arthritis
Wessels, J. A. M., van der Kooij, S. M., le Cessie, S., Kievit, W., Barerra, P., Allaart, C. F., Huizinga, T. W. J., & Guchelaar, H. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22640 · Cited by 247 · see citing works
Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics
Moore, A. R., & McQuay, J. H. (1997) · Pain · doi:10.1016/s0304-3959(96)03291-5 · Cited by 236 · see citing works
Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports
Moore, R. A., Derry, S., Makinson, G., & McQuay, H. J. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1704 · Cited by 223 · see citing works
Self-citation
Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review
Straube, S., Derry, S., McQuay, H. J., & Moore, R. A. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03200.x · Cited by 173 · see citing works
Self-citation
Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results
Moore, R. A., Edwards, J. E., & McQuay, H. J. (2005) · Pain · doi:10.1016/j.pain.2005.05.001 · Cited by 172 · see citing works
Self-citation
Marked Interindividual Variability in the Response to Selective Inhibitors of Cyclooxygenase-2
Fries, S., Großer, T., Price, T. S., Lawson, J. A., Kapoor, S. C., DeMarco, S., Pletcher, M. T., Wiltshire, T., & FitzGerald, G. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.002 · Cited by 139 · see citing works
Use of the Cumulative Proportion of Responders Analysis Graph to Present Pain Data Over a Range of Cut-Off Points: Making Clinical Trial Data More Understandable
Farrar, J. T., Dworkin, R. H., & Max, M. B. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.08.018 · Cited by 133 · see citing works
Current evidence for a genetic modulation of the response to analgesics
Lötsch, J., & Geißlinger, G. (2006) · Pain · doi:10.1016/j.pain.2006.01.010 · Cited by 132 · see citing works
Results of a randomized, dose-ranging trial of etoricoxib in patients with osteoarthritis
Gottesdiener, K. M. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.9.1052 · Cited by 121 · see citing works
Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies
Bingham, C. O., Sebba, A. I., Rubin, B. R., RUOFF, G. E., Kremer, J. M., Bird, S., Smugar, S. S., Fitzgerald, B. J., O'Brien, K., & Tershakovec, A. M. (2006) · Rheumatology · doi:10.1093/rheumatology/kel296 · Cited by 121 · see citing works
Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems
McQuay, H., Carroll, D., & Moore, A. R. (1996) · Pain · doi:10.1016/0304-3959(95)00116-6 · Cited by 118 · see citing works
Efficacy and Tolerability Profile of Etoricoxib in Patients with Osteoarthritis: A Randomized, Double-blind, Placebo and Active-comparator Controlled 12-Week Efficacy Trial
LEUNG, A. T., Malmström, K., Gallacher, A., Sarembock, B., Poór, G., Beaulieu, A. D., Castro, R. S., Sanchez, M., & Ng, J. (2002) · Current Medical Research and Opinion · doi:10.1185/030079902125000282 · Cited by 117 · see citing works
Genetic variability and clinical efficacy of morphine
Klepstad, P., Dale, O., Skorpen, F., Borchgrevink, P. C., & Kaasa, S. (2005) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2005.00772.x · Cited by 102 · see citing works
Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies
McQuay, H. J., & Moore, R. A. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02723.x · Cited by 99 · see citing works
Self-citation
Neuroimaging of pain mechanisms
Tracey, I. (2007) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3282efc58b · Cited by 81 · see citing works
Evaluation of the efficacy and safety of etoricoxib compared with naproxen in two, 138-week randomised studies of patients with osteoarthritis
Reginster, J., Malmström, K., Mehta, A., Bergman, G., Ko, A. T., Curtis, S., & Reicin, A. S. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.059162 · Cited by 67 · see citing works
Evaluation of the Comparative Efficacy of Etoricoxib and Ibuprofen for Treatment of Patients With Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial
Wiesenhutter, C. W., Boice, J. A., Ko, A. T., Sheldon, E. A., Murphy, F. T., Wittmer, B. A., Aversano, M. L., & Reicin, A. S. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.4.470 · Cited by 67 · see citing works
A randomized placebo-controlled trial comparing the efficacy of etoricoxib 30 mg and ibuprofen 2400 mg for the treatment of patients with osteoarthritis
Puopolo, A. D., Boice, J. A., Fidelholtz, J., Littlejohn, T. W., Miranda, P., Berrocal, A., Ko, A. T., Cichanowitz, N., & Reicin, A. S. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.05.022 · Cited by 59 · see citing works
What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs
Moore, R. A., Derry, S., McQuay, H. J., & Paling, J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2373 · Cited by 53 · see citing works
Self-citation
Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores
Moore, R. A., Moore, O. A., Derry, S., & McQuay, H. J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2394 · Cited by 41 · see citing works
Self-citation
Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports
Moore, R. A., Derry, S., & McQuay, H. J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2422 · Cited by 32 · see citing works
Self-citation
Efficacy, Speed of Action and Tolerability of Almotriptan in the Acute Treatment of Migraine
Dahlöf, C. G. H., Pascual, J., Dodick, D., & Dowson, A. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.01080.x · Cited by 28 · see citing works
Mechanisms of pain in nonmalignant disease
Harvey, V. L., & Dickenson, A. H. (2008) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328300eb24 · Cited by 25 · see citing works
Individuals, averages, and evidence based medicine
Moore, A., Straube, S., Derry, S., & McQuay, H. (2008) · BMJ · doi:10.1136/bmj.a2585 · Cited by 14 · see citing works
Self-citation
Does this work for you?
Christakis, N. A. (2008) · BMJ · doi:10.1136/bmj.a2281 · Cited by 12 · see citing works

Flagged first, then by citations

1 of the 38 references couldn’t be matched to a known paper.

Sorted by citations

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub3 · Cited by 1,222 · see citing works
Pregabalin for acute and chronic pain in adults
Moore, R. A., Straube, S., Wiffen, P. J., Derry, S., & McQuay, H. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007076.pub2 · Cited by 786 · see citing works
Self-citation
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
Moore, A., Wiffen, P. J., Derry, S., & McQuay, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub2 · Cited by 729 · see citing works
Self-citation
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub2 · Cited by 719 · see citing works
Self-citation
Cannabis-based medicines for chronic neuropathic pain in adults
Mücke, M., Phillips, T., Radbruch, L., Petzke, F. W., & Häuser, W. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012182.pub2 · Cited by 605 · see citing works
Gabapentin for chronic neuropathic pain in adults
Wiffen, P. J., Derry, S., Bell, R. F., Rice, A. S., Tölle, T. R., Phillips, T., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub4 · Cited by 561 · see citing works
Self-citation
Regional anaesthesia to prevent chronic pain after surgery: a Cochrane systematic review and meta-analysis
Andreae, M. H., & Andreae, D. A. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet213 · Cited by 507 · see citing works
Opioids for neuropathic pain
McNicol, E. D., Midbari, A., & Eisenberg, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006146.pub2 · Cited by 435 · see citing works
A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity
Conaghan, P. G. (2011) · Rheumatology International · doi:10.1007/s00296-011-2263-6 · Cited by 414 · see citing works
Topical NSAIDs for chronic musculoskeletal pain in adults
Derry, S., Conaghan, P. G., da Silva, J. A. P., Wiffen, P. J., & Moore, A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007400.pub3 · Cited by 403 · see citing works
Self-citation
Perioperative intravenous ketamine for acute postoperative pain in adults
Brinck, E. C. V., Tiippana, E., Heesen, M. A., Bell, R. F., Straube, S., Moore, A., & Kontinen, V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012033.pub4 · Cited by 378 · see citing works
Pregabalin for neuropathic pain in adults
Derry, S., Bell, R. F., Straube, S., Wiffen, P. J., Aldington, D. J., & Moore, A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007076.pub3 · Cited by 386 · see citing works
Self-citation
“Evidence” in chronic pain–establishing best practice in the reporting of systematic reviews
Moore, A. R., Eccleston, C., Derry, S., Wiffen, P., Bell, R. F., Straube, S., & McQuay, H. (2010) · Pain · doi:10.1016/j.pain.2010.05.011 · Cited by 370 · see citing works
Self-citation
Pain measures and cut-offs - 'no worse than mild pain' as a simple, universal outcome
Moore, R. A., Straube, S., & Aldington, D. (2013) · Anaesthesia · doi:10.1111/anae.12148 · Cited by 362 · see citing works
Self-citation
Combination pharmacotherapy for the treatment of neuropathic pain in adults
Chaparro, L. E., Wiffen, P. J., Moore, R. A., & Gilron, I. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008943.pub2 · Cited by 323 · see citing works
Self-citation
Amitriptyline for neuropathic pain in adults
Moore, A., Derry, S., Aldington, D. J., Cole, P., & Wiffen, P. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub3 · Cited by 309 · see citing works
Self-citation
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
Moore, R. A., Wiffen, P. J., Derry, S., & Rice, A. S. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub3 · Cited by 297 · see citing works
Self-citation
Amitriptyline for neuropathic pain and fibromyalgia in adults
Moore, R. A., Derry, S., Aldington, D. J., Cole, P., & Wiffen, P. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub2 · Cited by 288 · see citing works
Self-citation
Expect analgesic failure; pursue analgesic success
Moore, A., Derry, S., Eccleston, C., & Kalso, E. (2013) · BMJ · doi:10.1136/bmj.f2690 · Cited by 271 · see citing works
Self-citation
Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data
Andreae, M. H., Carter, G. M., Shaparin, N., Suslov, K., Ellis, R. J., Ware, M. A., Abrams, D. I., Prasad, H., Wilsey, B. L., Indyk, D., et al. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.07.009 · Cited by 268 · see citing works
Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis
Soliman, N., Moisset, X., Ferraro, M. C., de Andrade, D. C., Baron, R., Belton, J. L., Bennett, D., Calvo, M., Dougherty, P. M., Gilron, I., et al. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00068-7 · Cited by 263 · see citing works
Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults
Gill, D., Derry, S., Wiffen, P. J., & Moore, A. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009183.pub2 · Cited by 253 · see citing works
Self-citation
Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews
Derry, S., Wiffen, P. J., Kalso, E. A., Bell, R. F., Aldington, D. J., Phillips, T., Gaskell, H., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008609.pub2 · Cited by 245 · see citing works
Self-citation
Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys
Rannou, F., Pelletier, J., & Martel‐Pelletier, J. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.11.007 · Cited by 237 · see citing works
Milnacipran for neuropathic pain and fibromyalgia in adults
Derry, S., Gill, D., Phillips, T., & Moore, R. A. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008244.pub2 · Cited by 224 · see citing works
Self-citation
Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis
van Walsem, A., Pandhi, S., Nixon, R. M., Guyot, P., Karabis, A., & Moore, R. A. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0554-0 · Cited by 224 · see citing works
Self-citation
Tramadol for neuropathic pain in adults
Duehmke, R. M., Derry, S., Wiffen, P. J., Bell, R. F., Aldington, D. J., & Moore, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003726.pub4 · Cited by 201 · see citing works
Self-citation
Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain
Moore, A. R., Straube, S., Paine, J., Phillips, C. J., Derry, S., & McQuay, H. J. (2010) · Pain · doi:10.1016/j.pain.2010.02.039 · Cited by 200 · see citing works
Self-citation
Carbamazepine for acute and chronic pain in adults
Wiffen, P. J., Derry, S., Moore, R. A., & McQuay, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451.pub2 · Cited by 197 · see citing works
Self-citation
Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: Examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction
Moore, A. R., Straube, S., Paine, J., Derry, S., & McQuay, H. J. (2011) · Pain · doi:10.1016/j.pain.2010.11.030 · Cited by 195 · see citing works
Self-citation
Ibuprofen with or without an antiemetic for acute migraine headaches in adults
Rabbie, R., Derry, S., & Moore, R. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008039.pub3 · Cited by 193 · see citing works
Self-citation
Topical lidocaine for neuropathic pain in adults
Derry, S., Wiffen, P. J., Moore, A., & Quinlan, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010958.pub2 · Cited by 192 · see citing works
Self-citation
Carbamazepine for chronic neuropathic pain and fibromyalgia in adults
Wiffen, P. J., Derry, S., Moore, A., & Kalso, E. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451.pub3 · Cited by 190 · see citing works
Self-citation
Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials
Tétreault, P., Mansour, A. R., Vachon‐Presseau, É., Schnitzer, T. J., Apkarian, A. V., & Baliki, M. N. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002570 · Cited by 187 · see citing works
Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials
Stiller, C., & Hjemdahl, P. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13505 · Cited by 188 · see citing works
Pharmacological interventions for pain in patients with temporomandibular disorders
Mujakperuo, H. R., Watson, M. C., Morrison, R., & Macfarlane, T. V. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004715.pub2 · Cited by 180 · see citing works
Estimate at your peril: Imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses
Moore, A. R., Straube, S., Eccleston, C., Derry, S., Aldington, D. J., Wiffen, P. J., Bell, R. F., Hamunen, K., Phillips, C. J., & McQuay, H. (2011) · Pain · doi:10.1016/j.pain.2011.10.004 · Cited by 179 · see citing works
Self-citation
Carbamazepine for acute and chronic pain in adults
Wiffen, P. J., Derry, S., Moore, R. A., & McQuay, H. J. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005451 · Cited by 178 · see citing works
Self-citation
Duloxetine use in chronic painful conditions – individual patient data responder analysis
Moore, A., Cai, N., Skljarevski, V., & Tölle, T. R. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00341.x · Cited by 169 · see citing works
Lamotrigine for acute and chronic pain
Wiffen, P. J., Derry, S., & Moore, R. A. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006044.pub3 · Cited by 156 · see citing works
Self-citation
It's Good to Feel Better But It's Better To Feel Good and Even Better to Feel Good as Soon as Possible for as Long as Possible. Response Criteria and the Importance of Change at OMERACT 10: Figure 1.
Strand, V., Boers, M., Idzerda, L., Kirwan, J., Kvien, T. K., Tugwell, P., & Dougados, M. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.110392 · Cited by 155 · see citing works
Celecoxib for osteoarthritis
Puljak, L., Marin, A., Vrdoljak, D., Markotić, F., Utrobičić, A., & Tugwell, P. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009865.pub2 · Cited by 144 · see citing works
Pregabalin for pain in fibromyalgia in adults
Derry, S., Cording, M., Wiffen, P. J., Law, S., Phillips, T., & Moore, A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011790.pub2 · Cited by 145 · see citing works
Self-citation
Cannabinoids for fibromyalgia
Walitt, B. T., Klose, P., Fitzcharles, M., Phillips, T., & Häuser, W. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011694.pub2 · Cited by 143 · see citing works
Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study
Fischgrund, J. S., Rhyne, A. L., Franke, J., Sasso, R. C., Kitchel, S. H., Bae, H. W., Yeung, C. A., Truumees, E., Schaufele, M. K., Yuan, P. S., et al. (2018) · European Spine Journal · doi:10.1007/s00586-018-5496-1 · Cited by 139 · see citing works
Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion
Moore, R. A., Mhuircheartaigh, R. J. N., Derry, S., & McQuay, H. J. (2011) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e328343c569 · Cited by 138 · see citing works
Self-citation
Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions
Moore, R. A., Derry, S., Wiffen, P. J., Straube, S., & Aldington, D. J. (2014) · European Journal of Pain · doi:10.1002/ejp.649 · Cited by 136 · see citing works
Self-citation
Venlafaxine for neuropathic pain in adults
Gallagher, H. C., Gallagher, R. M., Butler, M., Buggy, D. J., & Henman, M. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011091.pub2 · Cited by 136 · see citing works
Oral nonsteroidal anti-inflammatory drugs for neuropathic pain
Moore, A., Chi, C., Wiffen, P. J., Derry, S., & Rice, A. S. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010902.pub2 · Cited by 135 · see citing works
Self-citation
Cannabinoids for adult cancer-related pain: systematic review and meta-analysis
Boland, E. G., Bennett, M., Allgar, V. L., & Boland, J. W. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2019-002032 · Cited by 135 · see citing works
A systematic literature review of strategies promoting early referral and reducing delays in the diagnosis and management of inflammatory arthritis
Villeneuve, É., Nam, J. L., Bell, M. J., Deighton, C. M., Felson, D. T., Hazes, J. M. W., McInnes, I. B., Silman, A. J., Solomon, D. H., Thompson, A., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201063 · Cited by 132 · see citing works
Acupuncture for neuropathic pain in adults
Ju, Z., Wang, K., Cui, H. S., Yao, Y., Liu, S., Zhou, J. J., Chen, T. Y., & Xia, J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012057.pub2 · Cited by 130 · see citing works
Numbers-needed-to-treat analyses – Do timing, dropouts, and outcome matter? Pooled analysis of two randomized, placebo-controlled chronic low back pain trials
Moore, A. R., Smugar, S. S., Wang, H., Peloso, P. M. J., & Gammaitoni, A. R. (2010) · Pain · doi:10.1016/j.pain.2010.07.013 · Cited by 129 · see citing works
Self-citation
Oxycodone for neuropathic pain in adults
Gaskell, H., Derry, S., Stannard, C., & Moore, R. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010692.pub3 · Cited by 129 · see citing works
Self-citation
Morphine for chronic neuropathic pain in adults
Cooper, T. E., Chen, J., Wiffen, P. J., Derry, S., Carr, D. B., Aldington, D. J., Cole, P., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011669.pub2 · Cited by 127 · see citing works
Self-citation
Pregabalin in fibromyalgia - responder analysis from individual patient data
Straube, S., Derry, S., Moore, R. A., Paine, J., & McQuay, H. J. (2010) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-11-150 · Cited by 126 · see citing works
Self-citation
Topical NSAIDs for chronic musculoskeletal pain in adults
Derry, S., Moore, R. A., & Rabbie, R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007400.pub2 · Cited by 126 · see citing works
Self-citation
Newer Biological Agents in Rheumatoid Arthritis
Strand, V., & Singh, J. A. (2010) · Drugs · doi:10.2165/11531980-000000000-00000 · Cited by 121 · see citing works
Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports
Straube, S., Derry, S., Moore, R. A., & McQuay, H. J. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/kep432 · Cited by 120 · see citing works
Self-citation
Nortriptyline for neuropathic pain in adults
Derry, S., Wiffen, P. J., Aldington, D. J., & Moore, R. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011209.pub2 · Cited by 116 · see citing works
Self-citation
Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults
Johnson, M. I., Claydon, L. S., Herbison, P., Jones, G., & Paley, C. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012172.pub2 · Cited by 118 · see citing works
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents
Eccleston, C., Cooper, T. E., Fisher, E., Anderson, B. J., & Wilkinson, N. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012537.pub2 · Cited by 115 · see citing works
Lamotrigine for chronic neuropathic pain and fibromyalgia in adults
Wiffen, P. J., Derry, S., & Moore, A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006044.pub4 · Cited by 104 · see citing works
Self-citation
Professionals underestimate patients' pain: a comprehensive review
Seers, T., Derry, S., Seers, K., & Moore, A. (2018) · Pain · doi:10.1097/j.pain.0000000000001165 · Cited by 102 · see citing works
Self-citation
Challenges in design and interpretation of chronic pain trials
Moore, A., Derry, S., & Wiffen, P. J. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet126 · Cited by 100 · see citing works
Self-citation
Mechanisms of pain transmission and pharmacologic management
Argoff, C. E. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.614934 · Cited by 100 · see citing works
Gabapentin for chronic neuropathic pain in adults
Moore, A., Wiffen, P. J., Derry, S., & McQuay, H. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938 · Cited by 99 · see citing works
Self-citation
Clinical effectiveness: an approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences
Moore, R. A., Derry, S., McQuay, H. J., Straube, S., Aldington, D., Wiffen, P., Bell, R. F., Kalso, E., & Rowbotham, M. C. (2010) · Pain · doi:10.1016/j.pain.2009.08.007 · Cited by 98 · see citing works
Self-citation
Efficacy of Qutenza® (capsaicin) 8% patch for neuropathic pain: A meta-analysis of the Qutenza Clinical Trials Database
Mou, J., Paillard, F., Turnbull, B. A., Trudeau, J., Stoker, M., & Katz, N. P. (2013) · Pain · doi:10.1016/j.pain.2013.04.044 · Cited by 97 · see citing works
Medical cannabis treatment for chronic pain: Outcomes and prediction of response
Aviram, J., Pud, D., Gershoni, T., Schiff‐Keren, B., Ogintz, M., Vulfsons, S., Yashar, T., Adahan, H., Brill, S., Amital, H., et al. (2020) · European Journal of Pain · doi:10.1002/ejp.1675 · Cited by 98 · see citing works
PANLAR Consensus Recommendations for the Management in Osteoarthritis of Hand, Hip, and Knee
Rillo, O. L., Riera, H., Acosta, C., Liendo, V., Bolaños, J., Monterola, L., Nieto, E., Arape, R. D. C., Franco, L. M., Vera, M., et al. (2016) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000449 · Cited by 95 · see citing works
Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults
Derry, S., Wiffen, P. J., Moore, A., McNicol, E. D., Bell, R. F., Carr, D. B., McIntyre, M., & Wee, B. L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012638.pub2 · Cited by 95 · see citing works
Self-citation
Lacosamide for neuropathic pain and fibromyalgia in adults
Hearn, L., Derry, S., & Moore, R. A. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009318.pub2 · Cited by 95 · see citing works
Self-citation
Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons
Saloman, J. L., Scheff, N. N., Snyder, L. M., Ross, S. E., Davis, B. M., & Gold, M. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3480-15.2016 · Cited by 94 · see citing works
Opioids for chronic non-cancer pain in children and adolescents
Cooper, T. E., Fisher, E., Gray, A. L., Krane, E. J., Sethna, N. F., van Tilburg, M. A. L., Zernikow, B., & Wiffen, P. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012538.pub2 · Cited by 93 · see citing works
Oral paracetamol (acetaminophen) for cancer pain
Wiffen, P. J., Derry, S., Moore, A., McNicol, E. D., Bell, R. F., Carr, D. B., McIntyre, M., & Wee, B. L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012637.pub2 · Cited by 94 · see citing works
Self-citation
Transdermal fentanyl for cancer pain
Hadley, G., Derry, S., Moore, R. A., & Wiffen, P. J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010270.pub2 · Cited by 92 · see citing works
Self-citation
Gabapentin for fibromyalgia pain in adults
Cooper, T. E., Derry, S., Wiffen, P. J., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012188.pub2 · Cited by 92 · see citing works
Self-citation
Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review
Revel, F. B., Fayet, M., & Hagen, M. (2020) · Rheumatology and Therapy · doi:10.1007/s40744-020-00196-6 · Cited by 91 · see citing works
Topical lidocaine for neuropathic pain in adults
Derry, S., & Moore, A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010958 · Cited by 89 · see citing works
Self-citation
Buprenorphine for neuropathic pain in adults
Moore, R. A., Derry, S., Wiffen, P. J., Stannard, C., Aldington, D. J., Cole, P., & Knaggs, R. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011603 · Cited by 86 · see citing works
Self-citation
Milnacipran for pain in fibromyalgia in adults
Cording, M., Derry, S., Phillips, T., Moore, A., & Wiffen, P. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008244.pub3 · Cited by 84 · see citing works
Self-citation
How to define responders in osteoarthritis
Cooper, C. C., Adachi, J. D., Bardin, T., Berenbaum, F., Flamion, B., Jónsson, H., Kanis, J. А., Pelousse, F., Lems, W. F., Pelletier, J., et al. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.792793 · Cited by 83 · see citing works
Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults
Derry, S., Wiffen, P. J., Moore, R. A., McNicol, E. D., Bell, R. F., Carr, D. B., McIntyre, M., & Wee, B. L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012638 · Cited by 83 · see citing works
Self-citation
Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults
Derry, S., Wiffen, P. J., Häuser, W., Mücke, M., Tölle, T. R., Bell, R. F., & Moore, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012332.pub2 · Cited by 82 · see citing works
Self-citation
Antidepressants for chronic non-cancer pain in children and adolescents
Cooper, T. E., Heathcote, L. C., Clinch, J., Gold, J. I., Howard, R. F., Lord, S. M., Schechter, N. L., Wood, C. H., & Wiffen, P. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012535.pub2 · Cited by 80 · see citing works
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors
Sakurai, Y., Fujita, M., Kawasaki, S., Sanaki, T., Yoshioka, T., Higashino, K., Tofukuji, S., Yoneda, S., Takahashi, T., Koda, K., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001466 · Cited by 79 · see citing works
A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component
Atkinson, J. H., Slater, M. A., Capparelli, E. V., Patel, S. M., Wolfson, T. J., Gamst, A. C., ABRAMSON, I. S., Wallace, M. S., Funk, S. D., Rutledge, T. R., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000554 · Cited by 78 · see citing works
Antiepileptic drugs for chronic non-cancer pain in children and adolescents
Cooper, T. E., Wiffen, P. J., Heathcote, L. C., Clinch, J., Howard, R. F., Krane, E. J., Lord, S. M., Sethna, N. F., Schechter, N. L., & Wood, C. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012536.pub2 · Cited by 77 · see citing works
Oxycodone for neuropathic pain and fibromyalgia in adults
Gaskell, H., Moore, R. A., Derry, S., & Stannard, C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010692.pub2 · Cited by 76 · see citing works
Self-citation
Evidence for a central mode of action for etoricoxib (COX-2 inhibitor) in patients with painful knee osteoarthritis
Arendt‐Nielsen, L., Egsgaard, L. L., & Petersen, K. K. (2016) · Pain · doi:10.1097/j.pain.0000000000000562 · Cited by 75 · see citing works
Naproxen with or without an antiemetic for acute migraine headaches in adults
Law, S., Derry, S., & Moore, R. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009455.pub2 · Cited by 73 · see citing works
Self-citation
Herbal medicinal products or preparations for neuropathic pain
Boyd, A., Bleakley, C., Hurley, D. A., Gill, C. I. R., Hannon-Fletcher, M. P. A., Bell, P., & McDonough, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010528.pub4 · Cited by 74 · see citing works
Clonazepam for neuropathic pain and fibromyalgia in adults
Corrigan, R. A., Derry, S., Wiffen, P. J., & Moore, A. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009486.pub2 · Cited by 72 · see citing works
Self-citation
Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults
Law, S., Derry, S., & Moore, R. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008541.pub3 · Cited by 73 · see citing works
Self-citation
Systematic review of enriched enrolment, randomised withdrawal trial designs in chronic pain
Moore, R. A., Wiffen, P. J., Eccleston, C., Derry, S., Baron, R., Bell, R. F., Furlan, A. D., Gilron, I., Haroutounian, S., Katz, N. P., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000088 · Cited by 70 · see citing works
Self-citation
Diagnosis, prognosis and classification of early arthritis: results of a systematic review informing the 2016 update of the EULAR recommendations for the management of early arthritis
Hua, C., Daïen, C., Combe, B. G., & Landewé, R. (2017) · RMD Open · doi:10.1136/rmdopen-2016-000406 · Cited by 70 · see citing works
Methadone for neuropathic pain in adults
McNicol, E. D., Ferguson, M. C., & Schumann, R. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012499.pub2 · Cited by 69 · see citing works
Tramadol with or without paracetamol (acetaminophen) for cancer pain
Wiffen, P. J., Derry, S., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012508.pub2 · Cited by 67 · see citing works
Self-citation
Nonsteroidal Anti‐Inflammatory Drugs, Gastroprotection, and Benefit–Risk
Moore, R. A., Derry, S., Simon, L. S., & Emery, P. (2013) · Pain Practice · doi:10.1111/papr.12100 · Cited by 66 · see citing works
Self-citation

Nicotine-Induced Structural Plasticity in Mesencephalic Dopaminergic Neurons Is Mediated by Dopamine D3 Receptors and Akt-mTORC1 Signaling
Collo, G., Bono, F., Cavalleri, L., Plebani, L., Mitola, S. M. F., Pich, E. M., Millan, M. J., Zoli, M., Maskos, U., Spano, P., et al. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.084863 · Cited by 67 · see citing works
Dopamine D3 receptor and beta-2 containing nicotinic \nacetylcholine receptor are critical in mediating nicotine effects \non dopaminergic neurons morphology
Bono, F., Cavalleri, L., Mitola, S. M. F., Missale, M., Collo, L. R., Plebani, L., Merlo Pich, E., Zoli, M., Maskos, U., Millan, M. J., et al. (2013) · Institutional Research Information System (Università degli Studi di Brescia)
Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
Collo, G., Cavalleri, L., Zoli, M., Maskos, U., Ratti, E., & Pich, E. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00572 · Cited by 10 · see citing works
Nicotine enhances structural plasticity in mesencephalic dopaminergic neurons: involvement of dopamine D3 receptors and nicotinic acetylcholine receptors.
Plebani, L., Merlo Pich, E., Zoli, M., Spano, P. F., Cavalleri, L., Bono, F., Missale, M., & Collo, L. R. (2012) · Institutional Research Information System (Università degli Studi di Brescia)
Nicotine produces structural plasticity of mesencephalic dopaminergic neurons via activation of Akt-mTor pathway
Collo, L. R., Bono, F., Cavalleri, L., Missale, M., Plebani, L., Mitola, S. M. F., Merlo Pich, E., Zoli, M., Maskos, U., & Spano, P. F. (2012) · Institutional Research Information System (Università degli Studi di Brescia)

Authors: Moore, R. A., Moore, O. A., Derry, S., Peloso, P. M., Gammaitoni, A. R., & Wang, H.
Affiliations: John Radcliffe Hospital (GB)
Musgrave Park Hospital (GB)
University of Oxford (GB)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author: Moore, R A
Moore, O A
ORCID: Derry, S
Peloso, P M
Gammaitoni, A R
Wang, H
Venue: Annals of the Rheumatic Diseases
Publisher: Elsevier BV
Published: 2010-02
Volume: 69
Issue: 2
Pages: 374-379
ISSN: 0003-4967 (ISSN-L)
DOI: 10.1136/ard.2009.107805
PMC: PMC2800200
OpenAlex: W2103600429
Cited by: 279
References: 38
Citations by year: 2026: 3 · 2025: 7 · 2024: 8 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 14 · 2018: 13 · 2017: 38 · 2016: 27 · 2015: 31 · 2014: 25 · 2013: 32 · 2012: 16
FWCI: 2.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/2.0/ (vor)
Locations: Annals of the Rheumatic Diseases (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Oxford University Research Archive (ORA) (University of Oxford) (acceptedVersion, cc-by-nc)
HighWire Press Open Archive (submittedVersion)
Funders: Pfizer
AstraZeneca
National Institute for Health and Care Research
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords: etoricoxib, osteoarthritis, analgesia, number needed to treat, responder analysis, nicotine, Parkinson's disease risk, nicotinic acetylcholine receptors, alpha4beta2 nAChR, midbrain dopaminergic neurons, dendritic branching, dopamine D3 receptor
MeSH terms: Etoricoxib, Diffusion of Innovation, Dose-Response Relationship, Drug, Humans, Pain, Pain Measurement, Pyridines, Sulfones, Osteoarthritis, Hip, Randomized Controlled Trials as Topic, Treatment Outcome, Osteoarthritis, Knee, Cyclooxygenase 2 Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks