Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody (anti-dsDNA)

Swaak, T; Smeenk, R

doi:10.1136/ard.44.4.245

Cited by 89Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related DiseasesVasculitis and related conditions

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Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody (anti-dsDNA)

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Swaak, T, Smeenk, R·1985·Annals of the Rheumatic Diseases

DOI 10.1136/ard.44.4.245PMC PMC1001620

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Abstract

The diagnostic significance of anti-double-stranded deoxyribonucleic acid (anti-dsDNA) determination was evaluated in a prospective manner from 1974 to 1982 in a group of 441 patients without systemic lupus erythematosus whose sera were found to contain antibodies to dsDNA on routine screening (Farr assay). Within one year 69% (304) of these patients fulfilled the preliminary American Rheumatism Association (ARA) criteria for systemic lupus erythematosus (SLE). Eighty-two of the remaining 137 patients were followed up for several years. At the end of the study 52% of these patients had also developed systemic lupus erythematosus. Patients who developed systemic lupus erythematosus were characterised by the occurrence of relatively high avidity anti-dsDNA in the circulation compared with patients who did not develop systemic lupus erythematosus. It can be concluded that about 85% of patients without systemic lupus erythematosus with anti-dsDNA in the circulation will develop SLE within a few years. Taking into account the relative avidity of anti-dsDNA, as determined by calculation of Farr/polyethylene glycol (PEG) ratios, we conclude that patients with relatively high avidity anti-dsDNA are more prone to develop systemic lupus erythematosus than patients with relatively low avidity anti-dsDNA.

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High avidity anti-dsDNA antibodies have high predictive value for the development of SLE if present in patients with manifestations compatible with SLE who fulfil fewer than four ACR criteria at the time of evaluation (lupus-like disease, LLD).
“High avidity anti-dsDNA antibodies are more specific for SLE than those with low avidity 5 and have high predictive value for the development of SLE if present in patients with manifestations compatible with SLE who fulfil fewer than four ACR criteria at the time of evaluation (lupus-like disease, LLD). 6”
From A comparison between the Farr radioimmunoassay and a new automated fluorescence immunoassay for the detection of antibodies against double stranded DNA in serum (2002) · cites this paper as [6]

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Research works printed but not linked: 4

Cohen S A, Reynolds W F, Franklin E G, et al. Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis 1971; 21: 643-8.
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Authors: Swaak, T., & Smeenk, R.
Affiliations: University of Amsterdam (NL)
Venue: Annals of the Rheumatic Diseases
Publisher: Elsevier BV
Published: 1985-04
Volume: 44
Issue: 4
Pages: 245-251
ISSN: 0003-4967 (ISSN-L)
DOI: 10.1136/ard.44.4.245
PMC: PMC1001620
OpenAlex: W2137523132
Cited by: 89
References: 16
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 3.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Annals of the Rheumatic Diseases (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: anti-dsDNA antibodies, systemic lupus erythematosus, disease prediction, antibody avidity, Farr assay, polyethylene glycol, ARA classification criteria, autoantibodies
MeSH terms: Antibody Affinity, Antibodies, Antinuclear, DNA, Humans, Lupus Erythematosus, Systemic, Prognosis, Prospective Studies

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Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody (anti-dsDNA)

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