Prospective study of fluctuations of lupus anticoagulant activity and anticardiolipin antibody titre in patients with systemic lupus erythematosus
Open accessAbstract
Fluctuations of lupus anticoagulant activity and anticardiolipin antibody titres were studied in 53 patients with systemic lupus erythematosus (SLE). The median study time was 26 months with a median number of 12 samples. Lupus anticoagulant was measured by the kaolin clotting time (KCT) and dilute Russell viper venom time (dRVVT) assays; anticardiolipin antibodies were assayed by an enzyme linked immunosorbent assay (ELISA). Normal and increased KCTs or dRVVTs were seen during follow up in 13 and 12 patients, respectively. IgG anticardiolipin antibodies changed from negative to positive or positive to negative in 26 patients and IgM anticardiolipin antibodies in 16 patients. Disease activity and treatment with prednisone could account for these fluctuations in the kaolin clotting time (KCT) in 7 of 13 patients and in the dRVVT in 2 of 12 patients. Whole group analysis showed that the KCT, dRVVT, and IgM anticardiolipin antibodies were not associated with disease activity, in contrast with IgG anticardiolipin antibodies. During treatment with prednisone normal KCT and dRVVT results were obtained more easily than normal anticardiolipin antibody levels. It is recommended that lupus patients should not be classified as antiphospholipid antibody positive or negative on the basis of only one sample.
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In SLE, aPL often fluctuate and are often at low or moderate titres, which still confer risk.
“However, in SLE, aPL often fluctuate and are often at low or moderate titres, which still confer risk [41–43].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [42]
The Follow Up section reports that antiphospholipid antibody results fluctuated in patients with SLE. The paper does not establish that titres were often low or moderate, or that low or moderate titres conferred risk; it notes that the observed fluctuations were not accompanied by thrombosis or a change in platelet count. Page numbers are not available in our copy. (LLM, conf=0.88)
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Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus
Demir, S., Li, J., Magder, L. S., & Petri, M. (2021) · Rheumatology · doi:10.1093/rheumatology/keaa857 · Cited by 38 · see citing works
- Authors
- Out, H. J., van Vliet, M., de Groot, P. G., & Derksen, R. H.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 51
- Issue
- 3
- Pages
- 353-357
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC1004660
- OpenAlex
- W2043122841
- Cited by
- 42
- References
- 20
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 1
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- systemic lupus erythematosus, lupus anticoagulant, anticardiolipin antibodies, antiphospholipid antibodies, kaolin clotting time, dilute Russell viper venom time, IgG anticardiolipin antibodies, IgM anticardiolipin antibodies, disease activity, prednisone, anticoagulant activity
- MeSH terms
- Adolescent, Adult, Aged, Cardiolipins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G, Immunoglobulin M, Lupus Erythematosus, Systemic, Male, Middle Aged, Partial Thromboplastin Time, Prednisolone, Prospective Studies, Lupus Coagulation Inhibitor
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