Acute haemolytic anaemia and myolysis due to G6PD deficiency
Open accessAbstract
A 2-year-old African-American male patient with sickle cell trait developed cough, red coloured urine, pallor and fatigue. The patient was hospitalised. Diagnostic workup showed that he was glucose 6 phosphate dehydrogenase (G6PD) deficient in erythrocytes. He also had chest X-ray findings of pneumonia. His urine examination showed the presence of haemoglobin and myoglobin. On repeated questioning it was found that he had a moth ball in his mouth a few days prior to this medical episode. This case illustrates a rarely described complication of myolysis in G6PD deficient persons on exposure to a strong oxidant. A review of the literature showed that most people with G6PD deficiency tolerate exercise well without untoward effect in muscles. However, assay of myoglobin in urine has not been routinely performed in these patients during acute haemolytic episode, and thus it is uncertain how frequent myoglobulinaemia occurs in a similar stress situation.
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Kernicterus and severe hyperbilirubinemia are strongly associated with G6PD deficiency and can be exacerbated by haemolytic agents such as menthol and naphthalene.
“Kernicterus and severe hyperbilirubinemia are strongly associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency [6, 16] and can be exacerbated by haemolytic agents such as menthol and naphthalene [17–20].”
From A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand–Myanmar Border (2017) · cites this paper as [19]
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Glucose-6-phosphate dehydrogenase deficiency
Cappellini, M., & Fiorelli, G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60073-2 · Cited by 1,590 · see citing works
Beutler, E. (1994) · Blood · doi:10.1182/blood.v84.11.3613.bloodjournal84113613 · Cited by 737 · see citing works
Nkhoma, E. T., Poole, C., Vannappagari, V. X., Hall, S. A., & Beutler, E. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.12.005 · Cited by 709 · see citing works
NAPHTHALENE-INDUCED RESPIRATORY TRACT TOXICITY: METABOLIC MECHANISMS OF TOXICITY
Buckpitt, A. R., Boland, B. C., Isbell, M. A., Morin, D., Shultz, M. A., Baldwin, R. M., Chan, K., Karlsson, A., Lin, C., Taff, A., et al. (2002) · Drug Metabolism Reviews · doi:10.1081/dmr-120015694 · Cited by 143 · see citing works
Theodorou, A. A., Nikolaidis, M. G., Paschalis, V., Σακελλαρίου, Γ., Fatouros, I. G., Koutedakis, Y., & Jamurtas, A. Z. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181c67ecd · Cited by 70 · see citing works
Muscle glucose-6-phosphate dehydrogenase deficiency
Bresolin, N., Bet, L., Moggio, M. G., Meola, G., Fortunato, F., Comi, G. P., Adobbati, L., Geremia, L., Pittalis, S., & Scarlato, G. (1989) · Journal of Neurology · doi:10.1007/bf00314498 · Cited by 37 · see citing works
Glucose-6-Phosphate Dehydrogenase Lodi^844C: A Study on Its Expression in Blood Cells and Muscle
Ninfali, P., Bresolin, N., Baronciani, L., Fortunato, F., Comi, G., Magnani, M., & Scarlato, G. (2017) · Enzyme · doi:10.1159/000468887 · Cited by 28 · see citing works
Kimmick, G. G., & Owen, J. (1996) · Southern Medical Journal · doi:10.1097/00007611-199611000-00015 · Cited by 19 · see citing works
Jamurtas, A. Z., Fatouros, I. G., Koukosias, N., Manthou, E., Tofas, T., Yfanti, C., Nikolaidis, M. G., & Koutedakis, Y. (2006) · PubMed · Cited by 19 · see citing works
Muscle expression of glucose‐6‐phosphate dehydrogenase deficiency in different variants
Ninfali, P., Baronciani, L., Bardoni, A., & Bresolin, N. (1995) · Clinical Genetics · doi:10.1111/j.1399-0004.1995.tb04095.x · Cited by 16 · see citing works
Glucose 6-phosphate dehydrogenase deficiency in an elite long-distance runner
Demir, A. Y., van Solinge, W. W., van Oirschot, B. A., van Wesel, A. C. W., Vergouwen, P., Thimister, E., Maase, K., Rijksen, G., Schutgens, R. E. G., & van Wijk, R. (2009) · Blood · doi:10.1182/blood-2008-12-194746 · Cited by 6 · see citing works
Clara Epithelial Cell Depletion in the Lung
Sonar, S. S., & Dudda, J. C. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-496-8_18 · Cited by 1 · see citing works
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Squeezing for Life – Properties of Red Blood Cell Deformability
Huisjes, R., Bogdanova, A. Y., van Solinge, W. W., Schiffelers, R. M., Kaestner, L., & van Wijk, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00656 · Cited by 325 · see citing works
COVID-19 may enhance risk of thrombosis and hemolysis in the G6PD deficient patients
Aydemir, D., Dağlıoğlu, G., Candevir, A., Kurtaran, B., Bozdoğan, S. T., İnal, T. C., & Ulusu, N. N. (2021) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2021.1897457 · Cited by 30 · see citing works
New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis
Eziokwu, A. S., & Angelini, D. E. (2018) · Cureus · doi:10.7759/cureus.2387 · Cited by 15 · see citing works
Prins, T. J., Trip-Hoving, M., Paw, M. K., Ka, M. L., Win, N. N., Htoo, G., Hser, M. K., Chotivanich, K., Nosten, F., & McGready, R. (2017) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmw055 · Cited by 12 · see citing works
Talwar, M., Krishnamurthy, S., Parameswaran, N., Kumar, C. G. D., Haridasan, S., & Srinivas, B. H. (2018) · Paediatrics and International Child Health · doi:10.1080/20469047.2018.1439804 · Cited by 12 · see citing works
Odolini, S., Gobbi, F. G., Zammarchi, L., Migliore, S., Mencarini, P., Vecchia, M., Lauria, N. D., Schivazappa, S., Sabatini, T., Chianura, L. G., et al. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.07.018 · Cited by 6 · see citing works
Severe Rhabdomyolysis in Glucose-6-Phosphate Dehydrogenase Deficiency
Singh, B., Kaur, P., Chan, K. H., Lahita, R. G., Maroules, M., & Chandran, C. B. (2020) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2020.03.018 · Cited by 6 · see citing works
Xin, J. O. A., Majid, M., Utama, H., & Taib, F. (2022) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v21i3.59592 · Cited by 2 · see citing works
Kuwada, G., Murakami, A., Glaser, D. W., Ingraham, S. E., & Purohit, P. (2022) · PubMed Central · Cited by 2 · see citing works
Fever of unknown origin and rhabdomyolysis in an immigrant from Africa
Paesa, C. R., Huguet-Embún, L., Arenas-Miquelez, A. I., & Ruano, A. D. L. M. (2020) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2019.10.009 · Cited by 1 · see citing works
Fiebre de origen no filiado y rabdomiólisis en una inmigrante procedente de África
Paesa, C. R., Huguet-Embún, L., Arenas-Miquelez, A. I., & Ruano, A. D. L. M. (2019) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2019.10.011 · Cited by 1 · see citing works
Ioscoa, C., Eason, V., Gueyec, I., & Leavy, R. (2021) · Advances in Bioscience and Clinical Medicine · doi:10.7575/aiac.abcmed.v.9n.4p.24
Bhutani, V. K., & Lane, S. (2026) · Seminars in Perinatology · doi:10.1016/j.semperi.2026.152309
- Authors
- Mangat, C., Inoue, S., Saah, E., & Sharman, M.
- Affiliations
- Hurley Medical Center (US)
- Corresponding author
- Inoue, Susumu
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2014-09-18
- Volume
- 2014
- Pages
- bcr2014203631
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC4170498
- OpenAlex
- W2312613284
- Cited by
- 13
- References
- 12
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Methemoglobinemia and Tumor Lysis Syndrome
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- glucose-6-phosphate dehydrogenase deficiency, acute hemolytic anemia, myolysis, sickle cell trait, oxidant exposure, urinary myoglobin, pediatric patients
- MeSH terms
- Anemia, Hemolytic, Child, Preschool, Erythrocytes, Glucosephosphate Dehydrogenase, Glucosephosphate Dehydrogenase Deficiency, Hemoglobins, Hemoglobinuria, Humans, Male, Muscles, Myoglobin, Myoglobinuria, Naphthalenes, Sickle Cell Trait, Oxidants
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