Glucose-6-phosphate dehydrogenase deficiency

Cappellini, MD; Fiorelli, G

doi:10.1016/s0140-6736(08)60073-2

Cited by 1,590Neonatal Health and BiochemistryHemoglobinopathies and Related DisordersGlycogen Storage Diseases and Myoclonus

Glucose-6-phosphate dehydrogenase deficiency

Cappellini, MD, Fiorelli, G·2008·The Lancet

DOI 10.1016/s0140-6736(08)60073-2

Open this paper in CoChat — free account

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, being present in more than 400 million people worldwide. The global distribution of this disorder is remarkably similar to that of malaria, lending support to the so-called malaria protection hypothesis. G6PD deficiency is an X-linked, hereditary genetic defect due to mutations in the G6PD gene, which cause functional variants with many biochemical and clinical phenotypes. About 140 mutations have been described: most are single base changes, leading to aminoacid substitutions. The most frequent clinical manifestations of G6PD deficiency are neonatal jaundice, and acute haemolytic anaemia, which is usually triggered by an exogenous agent. Some G6PD variants cause chronic haemolysis, leading to congenital non-spherocytic haemolytic anaemia. The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress. Screening programmes for the disorder are undertaken, depending on the prevalence of G6PD deficiency in a particular community.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(08)60073-2

Cites

145 of 145 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Kernicterus and severe hyperbilirubinemia are strongly associated with G6PD deficiency and can be exacerbated by haemolytic agents such as menthol and naphthalene.
“Kernicterus and severe hyperbilirubinemia are strongly associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency [6, 16] and can be exacerbated by haemolytic agents such as menthol and naphthalene [17–20].”
From A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand–Myanmar Border (2017) · cites this paper as [18]
G6PDH deficiency imparts different phenotypes, from acute hemolytic anemia to chronic hemolysis.
“G6PDH deficiency is one of the most common enzyme defects in humans due to multiple mutations of the G6PDH gene and imparts different phenotypes, from acute hemolytic anemia to chronic hemolysis (30).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [30]
G6PDH deficiency is one of the most common enzyme defects in humans due to multiple mutations of the G6PDH gene.
“G6PDH deficiency is one of the most common enzyme defects in humans due to multiple mutations of the G6PDH gene and imparts different phenotypes, from acute hemolytic anemia to chronic hemolysis (30).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [30]
Most G6PDH-deficient patients are asymptomatic throughout their lifetime.
“Most G6PDH-deficient patients are asymptomatic throughout their lifetime and acute hemolytic anemia only occurs when triggered with certain drugs (antimalarial drugs such as primaquine), infections (hepatitis A virus), or pro-oxidative ingredients in food [e.g., fava beans, as already observed by the antiques (30)].”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [30]
Acute hemolytic anemia in G6PDH deficiency occurs only when triggered with certain drugs, infections, or pro-oxidative ingredients in food.
“Most G6PDH-deficient patients are asymptomatic throughout their lifetime and acute hemolytic anemia only occurs when triggered with certain drugs (antimalarial drugs such as primaquine), infections (hepatitis A virus), or pro-oxidative ingredients in food [e.g., fava beans, as already observed by the antiques (30)].”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [30]

The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works
The metabolic and molecular bases of inherited disease
Chen, Y.-T. (2001) · Medical Entomology and Zoology · Cited by 6,928 · see citing works
Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation
Hyperbilirubinemia, S. O. (2004) · PEDIATRICS · doi:10.1542/peds.114.1.297 · Cited by 2,835 · see citing works
Red Cell Metabolism: A Manual of Biochemical Methods.
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-985_1 · Cited by 2,326 · see citing works
A History of Western Philosophy.
Cunningham, G. W., & Russell, B. (1946) · The Philosophical Review · doi:10.2307/2181652 · Cited by 2,034 · see citing works
Red Cell Metabolism. A Manual of Biochemical Methods.
(1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-6-919_1 · Cited by 1,759 · see citing works
Glucose-6-phosphate Dehydrogenase
Löhr, G. W., & Waller, H. D. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50026-8 · Cited by 1,189 · see citing works
Space-Time Relationships in Somesthetic Localization
Jones, F. N. (1956) · Science · doi:10.1126/science.124.3220.484-a · Cited by 841 · see citing works
G6PD deficiency
Beutler, E. (1994) · Blood · doi:10.1182/blood.v84.11.3613.bloodjournal84113613 · Cited by 737 · see citing works
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria
Ruwende, C., Khoo, S. C., Snow, R. W., Yates, S. N. R., Kwiatkowski, D. P., Gupta, S., Warn, P. A., Allsopp, C. E. M., Gilbert, S. C., Peschu, N., et al. (1995) · Nature · doi:10.1038/376246a0 · Cited by 592 · see citing works
THE NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY: STUDIES USING THE GENE FOR G-6-PD-DEFICIENCY AS A MARKER
Beutler, E., YEH, M. K. Y., & Fairbanks, V. F. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.1.9 · Cited by 500 · see citing works
HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions
Reynolds, G. A., Basu, S. K., Osborne, T. F., Chin, D. J., Gil, G., Brown, M. S., Goldstein, J. L., & Luskey, K. L. (1984) · Cell · doi:10.1016/0092-8674(84)90549-x · Cited by 492 · see citing works
‘History of Western Philosophy’
Russell, P. (1949) · International Affairs · doi:10.1093/ia/25.2.247 · Cited by 409 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficiency
Luzzatto, L., Nannelli, C., & Notaro, R. (2016) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.11.006 · Cited by 405 · see citing works
The Hemolytic Effect of Primaquine and Related Compounds: a Review
Beutler, E. (1959) · Blood · doi:10.1182/blood.v14.2.103.103 · Cited by 398 · see citing works
Blood. Principles and practice of hematology
(1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)81612-5 · Cited by 374 · see citing works
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria
Clark, I. A., & Hunt, N. H. (1983) · Infection and Immunity · doi:10.1128/iai.39.1.1-6.1983 · Cited by 359 · see citing works
System-based approach to management of neonatal jaundice and prevention of kernicterus
Johnson, L. H., Bhutani, V. K., & Brown, A. K. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.123098 · Cited by 347 · see citing works
Diagnosis and management of G6PD deficiency.
Frank, J. (2005) · PubMed · Cited by 340 · see citing works
Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency
Cappadoro, M., Giribaldi, G., O'Brien, E., Turrini, F., Mannu, F., Ulliers, D., Simula, G., Luzzatto, L., & Arese, P. (1998) · Blood · doi:10.1182/blood.v92.7.2527 · Cited by 339 · see citing works
Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia
Kaplan, M., Renbaum, P., Levy‐Lahad, E., Hammerman, C., Lahad, A., & Beutler, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12128 · Cited by 339 · see citing works
Incidence and causes of severe neonatal hyperbilirubinemia in Canada
Sgro, M. D. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.060328 · Cited by 331 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficiency
Yaish, H. M. (2012) · Springer eBooks · doi:10.1007/978-3-642-02202-9_320 · Cited by 326 · see citing works
Glucose-6-phosphate dehydrogenase deficiency
Mehta, A. B., Mason, P. J., & Vulliamy, T. (2000) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.1999.0055 · Cited by 318 · see citing works
Evaluation and Treatment of Jaundice in the Term Newborn: A Kinder, Gentler Approach
Newman, T. B., & Maisels, M. J. (1992) · PEDIATRICS · doi:10.1542/peds.89.5.809 · Cited by 294 · see citing works
Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP + molecule and provides insights into enzyme deficiency
Au, S. W., Gover, S., Lam, V. M. S., et al. (2000) · Structure · doi:10.1016/s0969-2126(00)00104-0 · Cited by 287 · see citing works
Blood — Principles and Practice of Hematology
Vincent, P. C. (1995) · Pathology · doi:10.1016/s0031-3025(16)39713-6 · Cited by 286 · see citing works
Glucose-6-phosphate dehydrogenase deficiency and malaria
Ruwende, C., & Hill, A. V. S. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050253 · Cited by 270 · see citing works
Hematologically Important Mutations: Glucose-6-phosphate Dehydrogenase
Beutler, E., Vulliamy, T., & Luzzatto, L. (1996) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1996.0008 · Cited by 262 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial Parasites
Luzzatto, L., Usanga, E. A., & Reddy, S. (1969) · Science · doi:10.1126/science.164.3881.839 · Cited by 248 · see citing works
Isolation of human glucose-6-pbosphate debydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region
Persico, M. G., Viglietto, G., Martini, G., Toniolo, D., Paonessa, G., Moscatelli, C., Dono, R., Vulliamy, T., Luzzatto, L., & D’Urso, M. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.6.2511 · Cited by 244 · see citing works
Genetics of red cells and susceptibility to malaria
Luzzatto, L. (1979) · Blood · doi:10.1182/blood.v54.5.961.961 · Cited by 240 · see citing works
G6PD: Population genetics and clinical manifestations
Beutler, E. (1996) · Blood Reviews · doi:10.1016/s0268-960x(96)90019-3 · Cited by 239 · see citing works
Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.
Trask, B. J., Massa, H. F., Kenwrick, S. J., & Gitschier, J. M. (1991) · PubMed · Cited by 220 · see citing works
LIVER DISEASE IN HBsAg CARRIERS
de Sevilla, T. F., Martinez-Vazquez, J. M., Ocaña, I., Ruibal, Á., & Bacardí, R. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90243-4 · Cited by 201 · see citing works
Malaria and the Red Cell
Weatherall, D. J., Miller, L. H., Baruch, D. I., Marsh, K., Doumbo, O. K., Casals‐Pascual, C., & Roberts, D. J. (2002) · Hematology · doi:10.1182/asheducation-2002.1.35 · Cited by 197 · see citing works
Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. Report of a WHO Scientific Group.
(1967) · PubMed · Cited by 177 · see citing works
Biochemical Variants of Glucose-6-Phosphate Dehydrogenase Giving Rise to Congenital Nonspherocytic Hemolytic Disease
Beutler, E., Mathai, C. K., & Smith, J. E. (1968) · Blood · doi:10.1182/blood.v31.2.131.131 · Cited by 177 · see citing works
Glucose-6-Phosphate Dehydrogenase
Luzzatto, L., & Battistuzzi, G. (1985) · Springer eBooks · doi:10.1007/978-1-4615-9400-0_4 · Cited by 176 · see citing works
GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND MALARIA
Bienzle, U., Lucas, A., Ayeni, O., & Luzzatto, L. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90676-9 · Cited by 168 · see citing works
Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum.
Roth, E. F., Raventós-Suárez, C., Rinaldi, A., & Nagel, R. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.298 · Cited by 161 · see citing works
MATERNAL PYREXIA AND THE FETUS
Matthews, T. G., & Gaughan, B. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90479-0 · Cited by 160 · see citing works
Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East.
Kurdi-Haidar, B., Mason, P. J., Berrebi, A., et al. (1990) · PubMed · Cited by 158 · see citing works
Pathophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency.
Arese, P., & FLORA, A. D. (1990) · PubMed · Cited by 156 · see citing works
Ethnic Differences in Reactions to Drugs and Xenobiotics
Roberts, D. F. (1987) · Journal of Medical Genetics · doi:10.1136/jmg.24.9.574-b · Cited by 156 · see citing works
A Series of New Screening Procedures for Pyruvate Kinase Deficiency, Glucose-6-Phosphate Dehydrogenase Deficiency, and Glutathione Reductase Deficiency
Beutler, E., & Halász, Á. (1966) · Blood · doi:10.1182/blood.v28.6.942-a.942-a · Cited by 152 · see citing works
Molecular heterogeneity of glucose-6-phosphate dehydrogenase A-
Beutler, E., Kühl, W., Vives-Corrons, J. L., & Prchal, J. (1989) · Blood · doi:10.1182/blood.v74.7.2550.2550 · Cited by 148 · see citing works
The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character.
Dern, R. J., Beutler, E., & Alving, A. S. (1954) · PubMed · Cited by 139 · see citing works
A Series of New Screening Procedures for Pyruvate Kinase Deficiency, Glucose-6-Phosphate Dehydrogenase Deficiency, and Glutathione Reductase Deficiency
Beutler, E., & Halász, Á. (1966) · Blood · doi:10.1182/blood.v28.4.553.553 · Cited by 135 · see citing works
The genetics of glucose-6-phosphate dehydrogenase deficiency.
Beutler, E. (1990) · PubMed · Cited by 134 · see citing works
Glucose 6-phosphate dehydrogenase deficiency: from genotype to phenotype.
Luzzatto, L. (2006) · PubMed · Cited by 123 · see citing works
Mortality in a Cohort of Men Expressing the Glucose-6-Phosphate Dehydrogenase Deficiency
Cocco, P., Todde, P., Fornera, S., Bonaria Manca, M., Manca, P., & Rosa Sias, A. (1998) · Blood · doi:10.1182/blood.v91.2.706 · Cited by 112 · see citing works
Molecular heterogeneity of glucose-6-phosphate dehydrogenase A-
Beutler, E., Kühl, W., Vives-Corrons, J. L., et al. (1989) · Blood · doi:10.1182/blood.v74.7.2550.bloodjournal7472550 · Cited by 111 · see citing works
Sequence of human glucose-6-phosphate dehydrogenase cloned in plasmids and a yeast artificial chromosome
Chen, E. Y., Cheng, A., Lee, A. L., Kuang, W.-J., Hillier, L., Green, P., Schlessinger, D., Ciccodicola, A., & D’Urso, M. (1991) · Genomics · doi:10.1016/0888-7543(91)90465-q · Cited by 110 · see citing works
Hexose-monophosphate shunt activity in intact Plasmodium falciparum-infected erythrocytes and in free parasites
Atamna, H., Pascarmona, G., & Ginsburg, H. (1994) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(94)90098-1 · Cited by 107 · see citing works
The expression of uridine diphosphate glucuronosyltransferase gene is a major determinant of bilirubin level in heterozygous β‐thalassaemia and in glucose‐6‐phosphate dehydrogenase deficiency
Sampietro, M., Lupica, L., Perrero, L., Comino, A., di Montemuros, F. M., Cappellini, M. D., & Fiorelli, G. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.4113228.x · Cited by 98 · see citing works
Self-citation
G6PD Mediterranean accounts for the high prevalence of G6PD deficiency in Kurdish Jews
Oppenheim, A., Jury, C., Rund, D. G., Vulliamy, T., & Luzzatto, L. (1993) · Human Genetics · doi:10.1007/bf00218277 · Cited by 97 · see citing works
Neutrophil cytoplasmic autoantibodies and Wegener's granulomatosis.
Gans, R. O. B., Goldschmeding, R., Donker, A., et al. (1989) · PubMed · Cited by 97 · see citing works
Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific).
Ganczakowski, M., Town, M., Bowden, D. K., Vulliamy, T., Kaneko, A., Clegg, J. B., Weatherall, D. J., & Luzzatto, L. (1995) · Europe PMC (PubMed Central) · Cited by 96 · see citing works
Intracellular Restraint: A New Basis for the Limitation in Response to Oxidative Stress in Human Erythrocytes Containing Low-Activity Variants of Glucose-6-Phosphate Dehydrogenase
Gaetani, G. D., Parker, J. C., & Kirkman, H. N. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3584 · Cited by 92 · see citing works
Identification of the binding domain for NADP+ of human glucose-6-phosphate dehydrogenase by sequence analysis of mutants.
Hirono, A., Kühl, W., Gelbart, T., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.10015 · Cited by 89 · see citing works
Cytological mapping of the human glucose-6-phosphate dehydrogenase gene distal to the fragile-X site suggests a high rate of meiotic recombination across this site.
Szabo, P., Purrello, M., Rocchi, M., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7855 · Cited by 85 · see citing works
Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6‐phosphate‐dehydrogenase‐deficient granulocytes
Tsai, K.-J., Hung, I., Chow, C. K., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01174-0 · Cited by 84 · see citing works
Proceedings of the Conference on Genetic Polymorphisms and Geographic Variations in Disease.
(1962) · Annals of Internal Medicine · doi:10.7326/0003-4819-56-6-998_2 · Cited by 83 · see citing works
Two point mutations are responsible for G6PD polymorphism in Sardinia.
Vita, G. D., Alcalay, M., Sampietro, M., et al. (1989) · PubMed · Cited by 83 · see citing works
Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme
Naylor, C., Rowland, P., Basak, A. K., et al. (1996) · Blood · doi:10.1182/blood.v87.7.2974.bloodjournal8772974 · Cited by 83 · see citing works
Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.
Vulliamy, T., Othman, A., Town, M., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8568 · Cited by 81 · see citing works
Hematologically Important Mutations: Glucose-6-Phosphate Dehydrogenase
Vulliamy, T., Luzzatto, L., Hirono, A., et al. (1997) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1997.0147 · Cited by 77 · see citing works
Acute hemolysis due to naphthalene inhalation
Valaes, T., Doxiadis, S. A., & Fessas, P. (1963) · The Journal of Pediatrics · doi:10.1016/s0022-3476(63)80221-8 · Cited by 76 · see citing works
CONTRIBUTION OF HAEMOLYSIS TO JAUNDICE IN SEPHARDIC JEWISH GLUCOSE‐6‐PHOSPHATE DEHYDROGENASE DEFICIENT NEONATES
Kaplan, M., Vreman, H. J., Hammerman, C., et al. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.d01-1745.x · Cited by 76 · see citing works
An improved, simple screening method for detection of glucose‐6‐phosphate dehydrogenase deficiency
Tantular, I. S., & Kawamoto, F. (2003) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2003.01055.x · Cited by 76 · see citing works
H�molyse und Fehlen von Glucose-6-Phosphatdehydrogenase in roten Blutzellen
Waller, H. D., L�hr, G. W., & Tabatabai, M. (1957) · Journal of Molecular Medicine · doi:10.1007/bf01488728 · Cited by 74 · see citing works
Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency
Kaplan, M., Rubaltelli, F. F., Hammerman, C., et al. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)80138-7 · Cited by 72 · see citing works
Favism: clinical and biochemical data.
Kattamis, C., Kyriazakou, M., & Chaidas, S. (1969) · Journal of Medical Genetics · doi:10.1136/jmg.6.1.34 · Cited by 70 · see citing works
G6PD deficiency as protection againstfalciparum malaria: An epidemiologic critique of population and experimental studies
Greene, L. S. (1993) · American Journal of Physical Anthropology · doi:10.1002/ajpa.1330360609 · Cited by 69 · see citing works
Tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3' end of the gene.
Battistuzzi, G., D’Urso, M., Toniolo, D., Persico, G. M., & Luzzatto, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.5.1465 · Cited by 68 · see citing works
Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase–deficient heterozygotes
Kaplan, M., Hammerman, C., Vreman, H. J., Stevenson, D. K., & Beutler, E. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.115312 · Cited by 67 · see citing works
Both mutations in G6PD A — are necessary to produce the G6PD deficient phenotype
Town, M. M., Bautista, J. M., Mason, P. J., et al. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.3.171 · Cited by 66 · see citing works
The epidemiology of favism.
Belsey, M. A. (1973) · PubMed · Cited by 65 · see citing works
Hydrops fetalis and stillbirth in a male glucose-6-phosphate dehydrogenase-deficient fetus possibly due to maternal ingestion of sulfisoxazole
Perkins, R. P. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90781-2 · Cited by 64 · see citing works
A SINGULAR DISEASE CHIEFLY AFFECTING THE RED BLOOD CELLS
Luisada, A. (1941) · Medicine · doi:10.1097/00005792-194105000-00003 · Cited by 63 · see citing works
Rapid epidemiologic assessment of glucose‐6‐phosphate dehydrogenase deficiency in malaria‐endemic areas in Southeast Asia using a novel diagnostic kit
Jalloh, A., Tantular, I. S., Pusarawati, S., et al. (2004) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2004.01237.x · Cited by 63 · see citing works
Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants
Fiorelli, G., di Montemuros, F. M., & Cappellini, M. D. (2000) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.1999.0056 · Cited by 61 · see citing works
Self-citation
Favism in a female newborn infant whose mother ingested fava beans before delivery
Corchia, C., Balata, A., Meloni, T., et al. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70178-8 · Cited by 58 · see citing works
Molecular Characterization of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency in Al-Ain District, United Arab Emirates
Bayoumi, R., Nur-e-Kamal, M. S. A., Tadayyon, M., et al. (1996) · Human Heredity · doi:10.1159/000154342 · Cited by 57 · see citing works
Marked Decline of Favism after Neonatal Glucose-6-Phosphate Dehydrogenase Screening and Health Education: The Northern Sardinian Experience
Meloni, T., Forteleoni, G., & Meloni, T. (2009) · Acta Haematologica · doi:10.1159/000204709 · Cited by 56 · see citing works
The genetics of glucose-6-phosphate dehydrogenase deficiency.
Charlton, R. W., Patz, I. M., & Borok, G. M. (1963) · PubMed · Cited by 54 · see citing works
New insights into G6PD deficiency.
Mason, P. J. (1996) · PubMed · Cited by 50 · see citing works
Kernicterus and G6PD Deficiency—a Case Series from Oman
Nair, A. K., & Khusaiby, S. M. A. (2003) · Journal of Tropical Pediatrics · doi:10.1093/tropej/49.2.74 · Cited by 50 · see citing works
The CpG island in the 5′ region of the G6PD gene of man and mouse
Toniolo, D., Filippi, M., Dono, R., et al. (1991) · Gene · doi:10.1016/0378-1119(91)90078-p · Cited by 50 · see citing works
Plasmodium falciparum: Thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes
Miller, J., Golenser, J., Spira, D. T., & Kosower, N. S. (1984) · Experimental Parasitology · doi:10.1016/0014-4894(84)90097-3 · Cited by 49 · see citing works
SEVERE MALARIA AND GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY: A REAPPRAISAL OF THE MALARIA/G-6-P.D. HYPOTHESIS
Martin, S. K., Miller, L. H., Alling, D. W., Okoye, V. C. N., Esan, G. J. F., Osunkoya, B. O., & Deane, M. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90946-2 · Cited by 47 · see citing works
Molecular heterogeneity of glucose-6-phosphate dehydrogenase (G6PD) variants in Italy.
di Montemuros, F. M., Dotti, C., Tavazzi, D., et al. (1997) · PubMed · Cited by 47 · see citing works
Membrane cross bonding in red cells in favic crisis: a missing link in the mechanism of extravascular haemolysis
Fischer, T. M., Meloni, T., Pescarmona, G., et al. (1985) · British Journal of Haematology · doi:10.1111/j.1365-2141.1985.tb02976.x · Cited by 46 · see citing works
Favism and Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase-Deficient Subjects in North Sardinia
Meloni, T., Forteleoni, G., Dore, A., et al. (2009) · Acta Haematologica · doi:10.1159/000206700 · Cited by 44 · see citing works
Annotation
Mason, P. J. (1996) · British Journal of Haematology · doi:10.1111/j.1365-2141.1996.tb00001.x · Cited by 44 · see citing works
Amino acid substitutions at the dimer interface of human glucose‐6‐phosphate dehydrogenase that increase thermostability and reduce the stabilising effect of NADP
Scopes, D. A., Bautista, J. M., Naylor, C. E., et al. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2510382.x · Cited by 43 · see citing works
Plasmodium Falciparum Malaria and Human Red Cells. II. Red Cell Genetic Traits and Resistance Against Malaria
Guggenmoos-Holzmann, I., Bienzle, U., & Luzzatto, L. (1981) · International Journal of Epidemiology · doi:10.1093/ije/10.1.16 · Cited by 43 · see citing works
New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia
Mason, P., Sonati, M. D. F., Macdonald, D., et al. (1995) · Blood · doi:10.1182/blood.v85.5.1377.bloodjournal8551377 · Cited by 41 · see citing works
Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysis
Hafez, M. M., Amar, E.-S., Zedan, M., et al. (1986) · The Journal of Pediatrics · doi:10.1016/s0022-3476(86)80833-2 · Cited by 39 · see citing works
Promoter Function of the Human Glucose‐6‐Phosphate Dehydrogenase Gene Depends on Two GC Boxes that are Cell Specifically Controlled
Philippe, M., Larondelle, Y., Lemaigre, F. P., et al. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb20062.x · Cited by 39 · see citing works
Multiple G6PD mutations are associated with a clinical and biochemical phenotype similar to that of G6PD Mediterranean
Cappellini, M. D., di Montemuros, F. M., Bellis, G. D., et al. (1996) · Blood · doi:10.1182/blood.v87.9.3953.bloodjournal8793953 · Cited by 39 · see citing works
Self-citation
Anemia and the liver
Edwards, C. Q. (2002) · Clinics in Liver Disease · doi:10.1016/s1089-3261(02)00050-8 · Cited by 38 · see citing works
Role of hemolysis in neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency
Seidman, D. S., Shiloh, M., Stevenson, D. K., et al. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70177-x · Cited by 37 · see citing works
Molecular anatomy of the human glucose 6‐phosphate dehydrogenase core promoter
Franzè, A., Ferrante, M. I., Fusco, F., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01259-9 · Cited by 37 · see citing works
The interaction between Gilbert's syndrome and G6PD deficiency influences bilirubin levels
Domenica, M., Cappellini, Martinez, F. S., et al. (1999) · British Journal of Haematology · doi:10.1111/j.1365-2141.1999.1331a.x · Cited by 36 · see citing works
A single mutation 202G>A in the human glucose-6-phosphate dehydrogenase gene (G6PD) can cause acute hemolysis by itself
Hirono, A., Kawate, K., Honda, A., et al. (2002) · Blood · doi:10.1182/blood.v99.4.1498 · Cited by 36 · see citing works
Clinical and haematological consequences of recurrent G6PD mutations and a single new mutation causing chronic nonspherocytic haemolytic anaemia
Vulliamy, T., Kaeda, J., Ait‐Chafa, D., et al. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00763.x · Cited by 36 · see citing works
Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Fars province of Iran.
Karimi, M., di Montemuros, F. M., Danielli, M. G., et al. (2003) · PubMed · Cited by 34 · see citing works
Erythrocyte Enzymopathies in the Newborn
Matthay, K. K., & Mentzer, W. C. (1981) · Clinics in Haematology · doi:10.1016/s0308-2261(21)00208-3 · Cited by 34 · see citing works
Diabetic ketoacidosis does not precipitate haemolysis in patients with the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency.
Shalev, O., Wollner, A., & MENCZEL, J. (1984) · BMJ · doi:10.1136/bmj.288.6412.179 · Cited by 33 · see citing works
Chloramphenicol-Induced Hemolysis in Caucasian Glucose-6-Phosphate Dehydrogenase Deficiency
McCaffrey, R. P., Halsted, C. H., Wahab, M. F. A., et al. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-5-722 · Cited by 32 · see citing works
Genetic Variation in the Host and Adaptive Phenomena inPlasmodium falciparumInfection
Luzzatto, L., F, O. S., & Martini, G. (1983) · Novartis Foundation symposium · doi:10.1002/9780470715444.ch10 · Cited by 31 · see citing works
VIRAL HEPATITIS IN G.-6-P.D. DEFICIENCY
Choremis, C., Kattamis, C., Kyriazakou, M., et al. (1966) · The Lancet · doi:10.1016/s0140-6736(66)90098-5 · Cited by 31 · see citing works
THE MALARIA/G.-6-P.D. HYPOTHESIS
Luzzatto, L., & Bienzle, U. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91857-9 · Cited by 30 · see citing works
Genetic red cell disorders and severity of falciparum malaria in Myanmar.
Oo, M., Tin-Shwe, Marlar-Than, et al. (1995) · PubMed · Cited by 27 · see citing works
GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY IN NIGERIANS WITH JAUNDICE ASSOCIATED WITH LOBAR PNEUMONIA
Tugwell, P. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91602-4 · Cited by 26 · see citing works
An Ashkenazi Jewish woman presenting with favism
Lim, F., Vulliamy, T., & Abdalla, S. H. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.017426 · Cited by 25 · see citing works
Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation.
Maestrini, E., Rivella, S. B., Tribioli, C., et al. (1992) · PubMed · Cited by 24 · see citing works
A novel C to T substitution at nucleotide 1360 of cDNA which abolishes a natural Hha l site accounts for a new G6PD deficiency gene in Chinese
Perng, L.-L., Chiou, S., Liu, T., et al. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.3.205 · Cited by 24 · see citing works
Molecular Analysis of Eight Biochemically Unique Glucose-6-Phosphate Dehydrogenase Variants Found in Japan
Hirono, A., Fujii, H., Takano, T., et al. (1997) · Blood · doi:10.1182/blood.v89.12.4624 · Cited by 23 · see citing works
Hepatitis A and Cytomegalovirus Infection Precipitating Acute Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency
Siddiqui, T., & Khan, A. (1998) · Military Medicine · doi:10.1093/milmed/163.6.434 · Cited by 23 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficiency and Hyperbilirubinemia in the Newborn
López, R. (1971) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1971.02110010102020 · Cited by 21 · see citing works
Glucose 6‐phosphate dehydrogenase deficiency and red cell membrane defects: additive or synergistic interaction in producing chronic haemolytic anaemia
Alfinito, F., Calabrò, V., Cappellini, M. D., et al. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04885.x · Cited by 20 · see citing works
Self-citation
Glucose‐6‐phosphate dehydrogenase deficiency in Sicily. Incidence, biochemical characteristics and clinical implications
Schilirò, G., Russo, A., Curreri, R., et al. (1979) · Clinical Genetics · doi:10.1111/j.1399-0004.1979.tb01759.x · Cited by 20 · see citing works
A simple laboratory procedure for the recognition of A− (African type) G-6PD deficiency in acute haemolytic crisis
Ringelhahn, B. (1972) · Clinica Chimica Acta · doi:10.1016/0009-8981(72)90193-3 · Cited by 20 · see citing works
G6PD Ferrara I has the same two mutations as G6PD A(-) but a distinct biochemical phenotype
Cappellini, M. D., Sampietro, M., Toniolo, D., et al. (1994) · Human Genetics · doi:10.1007/bf00210598 · Cited by 17 · see citing works
Self-citation
Sickle Cell Trait and Glucose-6-Phosphate Dehydrogenase Deficiency
Hoiberg, A. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340120093019 · Cited by 16 · see citing works
Prenatal Diagnosis of Glucose-6-Phosphate-Dehydrogenase Deficiency
Beutler, E., Kühl, W., Fox, M., et al. (2009) · Acta Haematologica · doi:10.1159/000204729 · Cited by 16 · see citing works
[New aspects of the biochemical alterations in the erythrocytes of patients with favism; almost complete absence of glucose-6-phosphate dehydrogenase].
Sansone, G., & Segni, G. (1958) · PubMed · Cited by 15 · see citing works
Modern Genetic Concepts and Techniques in the Study of Parasites
(1983) · Immunological Communications · doi:10.3109/08820138309066878 · Cited by 15 · see citing works
Sub-Saharan influence on the Canary Islands population deduced from G6PD gene sequence analysis.
Pinto, F. M., González, A. M., Hernández, M., et al. (1996) · PubMed · Cited by 13 · see citing works
Amino acid conservation and clinical severity of human glucose-6-phosphate dehydrogenase mutations
Cheng, Y., Tang, T. K., & Hwang, M. (1999) · Journal of Biomedical Science · doi:10.1007/bf02256441 · Cited by 13 · see citing works
Congenital Dyserythropoietic Anemia Type II Associated with G6PD Seattle in a Sicilian Child
Gangarossa, S., Romano, V., del Giudice, E. M., et al. (2009) · Acta Haematologica · doi:10.1159/000204087 · Cited by 12 · see citing works
Acute hemolytic anemia precipitated by myocardial infarction and percardial tamponade in G6PD deficiency
Lee, D. H., Warkentin, T. E., Neame, P. B., et al. (1996) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199602)51:2 · Cited by 12 · see citing works
Muscle glucose 6‐phosphate dehydrogenase (G6PD) deficiency and oxidant stress during physical exercise
Ninfali, P., & Bresolin, N. (1995) · Cell Biochemistry and Function · doi:10.1002/cbf.290130412 · Cited by 11 · see citing works
Hereditary Spherocytosis and Glucose-6-Phosphate Dehydrogenase Deficiency
Rubins, J. M. (1977) · JAMA · doi:10.1001/jama.1977.03270350057025 · Cited by 10 · see citing works
ETIOLOGICAL ASPECTS OF FAVISM11Supported by CNR Grants PF 84.00864.51 to P.A. and PF 60/84. 0087.51 to G.F., and by the Thalassemia Research institute (CNR Cagliari).
Arese, P., Mannuzzu, L. M., Turrini, F., et al. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-772640-3.50008-1 · Cited by 10 · see citing works
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND ACUTE RENAL FAILURE
Angle, C. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91619-4 · Cited by 9 · see citing works
Pyruvate kinase deficiency. Association with G6PD deficiency.
(1992) · BMJ · doi:10.1136/bmj.305.6856.760 · Cited by 9 · see citing works
Brilliant cresyl blue screening test for demonstrating glucose-6-phosphate dehydrogenase deficiency in red cells
Bernstein, R. E. (1963) · Clinica Chimica Acta · doi:10.1016/0009-8981(63)90217-1 · Cited by 8 · see citing works
Human Enzyme Polymorphism in the Canary Islands
Cabrera, V. M., lez, P. G. A., & Salo, W. L. (1996) · Human Heredity · doi:10.1159/000154353 · Cited by 8 · see citing works
Glucose-6-phosphate dehydrogenase and other genetic factors interacting with drugs.
Luzzatto, L. (1986) · PubMed · Cited by 7 · see citing works
Different polymorphic variants of glucose‐6‐phiosphate dehydrogenase (G6PD) in Italy.
Fiorelli, G., Manoussakis, C., Sampietro, M., et al. (1989) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1989.tb01789.x · Cited by 6 · see citing works
Self-citation
REVERSIBLE RENAL FAILURE AND G.-6-P.D. DEFICIENCY
Selroos, O. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91724-2 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s002 · Cited by 4,792 · see citing works
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2020
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc20-s002 · Cited by 3,187 · see citing works
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s002 · Cited by 3,116 · see citing works
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576 · see citing works
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469 · see citing works
Redox Reactions and Microbial Killing in the Neutrophil Phagosome
Winterbourn, C. C., & Kettle, A. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4827 · Cited by 468 · see citing works
Evidence and Implications of Mortality Associated with Acute Plasmodium vivax Malaria
Baird, J. K. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00074-12 · Cited by 398 · see citing works
Inborn defects in the antioxidant systems of human red blood cells
van Zwieten, R., Verhoeven, A. J., & Roos, D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.022 · Cited by 179 · see citing works
Characterization of G6PD Genotypes and Phenotypes on the Northwestern Thailand-Myanmar Border
Bancone, G., Chu, C. S., Somsakchaicharoen, R., Chowwiwat, N., Parker, D. M., Charunwatthana, P., White, N. J., & Nosten, F. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116063 · Cited by 99 · see citing works
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria
Watson, J., Taylor, W. R. J., Bancone, G., Chu, C. S., Jittamala, P., & White, N. J. (2018) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0006440 · Cited by 77 · see citing works
HbA1c for type 2 diabetes diagnosis in Africans and African Americans: personalized medicine now
Paterson, A. D. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002384 · Cited by 26 · see citing works
Contribution of genetic factors to high rates of neonatal hyperbilirubinaemia on the Thailand-Myanmar border
Bancone, G., Gornsawun, G., Peerawaranun, P., Penpitchaporn, P., Paw, M. K., Poe, D. D., Win, D., Cicelia, N., Mukaka, M., Archasuksan, L., et al. (2022) · PLOS Global Public Health · doi:10.1371/journal.pgph.0000475 · Cited by 14 · see citing works
Acute haemolytic anaemia and myolysis due to G6PD deficiency
Mangat, C., Inoue, S., Saah, E., & Sharman, M. (2014) · BMJ Case Reports · doi:10.1136/bcr-2014-203631 · Cited by 13 · see citing works
A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand–Myanmar Border
Prins, T. J., Trip-Hoving, M., Paw, M. K., Ka, M. L., Win, N. N., Htoo, G., Hser, M. K., Chotivanich, K., Nosten, F., & McGready, R. (2017) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmw055 · Cited by 12 · see citing works

Topical herbal medicine causing haemolysis in glucose-6-phosphate dehydrogenase deficiency
(2002) · Acta Paediatrica · doi:10.1080/080352502760272768 · Cited by 3 · see citing works
Haemolysis due to glucose-6-phosphate dehydrogenase deficiency in Malaya
Eng, L. L., Pillay, R. P., & Virik, H. K. (1966) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(66)90039-3 · Cited by 5 · see citing works
Liefe-threatening haemolysis induced by henna in a Sudanese child with glucose-6-phosphate dehydrogenase deficiency
Kheir, A. E. M., Gaber, I., Gafer, S. M. A., et al. (2017) · Eastern Mediterranean Health Journal · doi:10.26719/2017.23.1.28 · Cited by 6 · see citing works
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism.
Calabrò, V., Cascone, A., Malaspina, P., et al. (1989) · PubMed · Cited by 15 · see citing works
Acute haemolysis with Ambilhar treatment in glucose-6-phosphate dehydrogenase deficiency
McCaffrey, R. P., Farid, Z., & Kent, D. C. (1972) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(72)90097-1 · Cited by 11 · see citing works

Authors: Cappellini, M., & Fiorelli, G.
Affiliations: University of Milan (IT)
Venue: The Lancet
Publisher: Elsevier BV
Published: 2008-01
Volume: 371
Issue: 9606
Pages: 64-74
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(08)60073-2
OpenAlex: W2088888368
Cited by: 1,590
References: 145
Citations by year: 2026: 67 · 2025: 70 · 2024: 76 · 2023: 72 · 2022: 98 · 2021: 97 · 2020: 118 · 2019: 84 · 2018: 87 · 2017: 104 · 2016: 98 · 2015: 90 · 2014: 96 · 2013: 110 · 2012: 91
FWCI: 9.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords: glucose-6-phosphate dehydrogenase deficiency, G6PD variants, X-linked inheritance, neonatal jaundice, acute hemolytic anemia, chronic hemolysis, oxidative stress, G6PD screening
MeSH terms: Anemia, Hemolytic, Female, Glucosephosphate Dehydrogenase, Glucosephosphate Dehydrogenase Deficiency, Humans, Infant, Newborn, Jaundice, Neonatal, Malaria, Male, Molecular Biology, Pentose Phosphate Pathway

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucose-6-phosphate dehydrogenase deficiency

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks