‘Too much of a coincidence’: identical twins with exertional heatstroke in the same race
Open accessAbstract
This report discusses a unique case of monozygotic male twins who both collapsed with exertional heat stroke (EHS) during the same marathon in relatively cool conditions. The twins were official race pacers in a popular city marathon held in the early spring in the UK. Both recovered uneventfully due to the prompt recognition of EHS and use of aggressive cooling measures, which prevented life-threatening complications. The case illustrates that EHS is a complex illness with a possible genetic predisposition, which can occur among runners even in cooler conditions. This link is explored together with the influence of their role as race pacers and the additional backpack worn in the development of EHS.
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EHS is most common in marathons.
“In the latter, it is most common in marathons [14,44,45]”
From Nutrition-Related Adverse Outcomes in Endurance Sports Competitions: A Review of Incidence and Practical Recommendations (2020) · cites this paper as [14]
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Cites
Influence of body temperature on the development of fatigue during prolonged exercise in the heat
González‐Alonso, J., Teller, C., Andersen, S. L., Jensen, F. B., Hyldig, T., & Nielsen, B. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.1032 · Cited by 1,129 · see citing works
Exertional Heat Illness during Training and Competition
Armstrong, L. E., Casa, D. J., Millard-Stafford, M. L., Moran, D. S., Pyne, S. W., & Roberts, W. O. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802fa199 · Cited by 1,024 · see citing works
Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia
Hall, D. M., Buettner, G. R., Oberley, L. W., Xu, L., MATTHES, R. D., & GISOLFI, C. V. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h509 · Cited by 463 · see citing works
The physiological regulation of pacing strategy during exercise: a critical review
Tucker, R., & Noakes, T. D. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.057562 · Cited by 321 · see citing works
Ca2+ signalling and muscle disease
MacLennan, D. H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01566.x · Cited by 242 · see citing works
Casa, D. J., Armstrong, L. E., Kenny, G. P., O’Connor, F. G., & Huggins, R. A. (2012) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31825615cc · Cited by 229 · see citing works
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
Kourtis, N., Nikoletopoulou, V., & Tavernarakis, N. (2012) · Nature · doi:10.1038/nature11417 · Cited by 169 · see citing works
A 12-yr profile of medical injury and illness for the Twin Cities Marathon
Roberts, W. O. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009000-00004 · Cited by 166 · see citing works
The American Football Uniform: Uncompensable Heat Stress and Hyperthermic Exhaustion
Armstrong, L. E., Johnson, E. C., Casa, D. J., Ganio, M. S., McDermott, B. P., Yamamoto, L. M., Lopez, R. M., & Emmanuel, H. (2010) · Journal of Athletic Training · doi:10.4085/1062-6050-45.2.117 · Cited by 150 · see citing works
The “Golden Hour” for Heatstroke Treatment
Heled, Y., Rav-Acha, M., Shani, Y., et al. (2004) · Military Medicine · doi:10.7205/milmed.169.3.184 · Cited by 126 · see citing works
The Central Governor Model of Exercise Regulation Applied to the Marathon
Noakes, T. D. (2007) · Sports Medicine · doi:10.2165/00007256-200737040-00026 · Cited by 118 · see citing works
Protasi, F., Paolini, C., & Dainese, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171967 · Cited by 114 · see citing works
DeMartini, J. K., Casa, D. J., Belval, L. N., et al. (2014) · Journal of Athletic Training · doi:10.4085/1062-6050-49.3.26 · Cited by 89 · see citing works
Is There a Link between Exertional Heat Stroke and Susceptibility to Malignant Hyperthermia?
Sagui, E., Montigon, C., Abriat, A., Jouvion, A.-X., Duron-Martinaud, S., Canini, F., Zagnoli, F., Bendahan, D., Figarella-Branger, D. F., Bregigeon, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135496 · Cited by 55 · see citing works
Veltmeijer, M. T. W., Eijsvogels, T. M. H., Thijssen, D. H. J., & Hopman, M. T. E. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.04.007 · Cited by 44 · see citing works
Navarro, C. S., Casa, D. J., Belval, L. N., & Nye, N. S. (2017) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000403 · Cited by 42 · see citing works
Is there a link between malignant hyperthermia and exertional heat illness?
Hopkins, P. M. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2006.032516 · Cited by 34 · see citing works
The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats
Lam, K., Cheng, P., Lee, Y., Liu, Y.-P., Ding, C., Liu, W.-H., & Yen, M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.044 · Cited by 24 · see citing works
Exertional heat illness in half marathon runners: experiences of the Great North Run
Hawes, R. H., McMorran, J., & Vallis, C. J. (2010) · Emergency Medicine Journal · doi:10.1136/emj.2010.090928 · Cited by 22 · see citing works
Exertional Heat Stroke – The Athlete's Nemesis
Walter, E. J., Venn, R. M., & Stevenson, T. (2012) · Journal of the Intensive Care Society · doi:10.1177/175114371201300408 · Cited by 12 · see citing works
An Association Study of CASQ1 Gene Polymorphisms and Heat Stroke
Li, Y., Wang, Y., & Ma, L. (2014) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2014.03.004 · Cited by 10 · see citing works
Exertional Heat Stroke and Emergency Issues in High School Sport
Pagnotta, K. D., Mazerolle, S. M., & Casa, D. J. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e99d56 · Cited by 10 · see citing works
'Cool runnings': heat stroke in cool conditions
Robertson, B., & Walter, E. J. (2010) · Emergency Medicine Journal · doi:10.1136/emj.2009.083667 · Cited by 7 · see citing works
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Research works printed but not linked: 1
- Armstrong LE, Maresh CM, Crago AE, et al. Interpretation of aural temperatures during exercise, hyperthermia, and cooling therapy. Med Exerc Nutr Health 1994;3:9-16.
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Martínez-Sanz, J. M., Fernández Nuñez, A., Sospedra, I., Martínez-Rodríguez, A., Domínguez, R., González-Jurado, J. A., & Sánchez-Oliver, A. J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17114082 · Cited by 25 · see citing works
- Authors
- Smith, R., Jones, N., Martin, D., & Kipps, C.
- Affiliations
- Nuffield Orthopaedic Centre (GB)
- UCL Centre for Altitude, Space and Extreme Environment Medicine, Institute of Sport, Exercise and Health (ISEH), London, UK
- Division of Surgery and Interventional Sciences, Institute of Sport, Exercise and Health (ISEH), London, UK
- Corresponding author
- Smith, R
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2016-02-05
- Volume
- 2016
- Pages
- bcr2015212592
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC4746505
- OpenAlex
- W2299839231
- Cited by
- 16
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2021: 2 · 2020: 3 · 2019: 5 · 2016: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- exertional heat stroke, monozygotic twins, marathon running, genetic susceptibility, cooling measures, backpack weight
- MeSH terms
- Adult, Diseases in Twins, Physical Exertion, United Kingdom, Humans, Male, Running, Twins, Monozygotic, Heat Stroke
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