Very low carbohydrate diet and SGLT-2-inhibitor: double jeopardy in relation to ketoacidosis
Open accessAbstract
Diabetic euglycaemic ketoacidosis is a possible adverse effect of sodium–glucose co-transporter-2 inhibitors (SGLT2i). We report a case in which the combination of SGLT2i and a strict very low-carbohydrate diet led to severe diabetic ketoacidosis in a young Caucasian man with type 2 diabetes.
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Metabolic ketoacidosis with ketogenic diets is a hazard, particularly with sodium−glucose cotransporter 2 (SGLT2) inhibitors.
“Metabolic ketoacidosis with ketogenic diets is a hazard, particularly with sodium−glucose cotransporter 2 (SGLT2) inhibitors [82–87].”
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Ketoacidosis during a Low-Carbohydrate Diet
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Evidence-based European recommendations for the dietary management of diabetes
The Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD), Aas, A.-M., Axelsen, M., Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., et al. (2023) · Diabetologia · doi:10.1007/s00125-023-05894-8 · Cited by 262 · see citing works
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- Authors
- Tougaard, N. H., Faber, J., & Eldrup, E.
- Affiliations
- Herlev Hospital (DK)
- University of Copenhagen (DK)
- Corresponding author
- Tougaard, Ninna Hahn
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2019-04
- Volume
- 12
- Issue
- 4
- Pages
- e227516
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC6453281
- OpenAlex
- W2926743658
- Cited by
- 16
- References
- 12
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 1
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ Case Reports (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- diabetic ketoacidosis, SGLT2 inhibitors, very low carbohydrate diet, type 2 diabetes, adverse drug reactions, food-drug interactions
- MeSH terms
- Sodium-Glucose Transporter 2 Inhibitors, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Diet, Reducing, Humans, Hypoglycemic Agents, Male, Obesity, Diabetic Ketoacidosis, Treatment Outcome, Directive Counseling, Diet, Carbohydrate-Restricted
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