The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
Open accessAbstract
BACKGROUND/AIMS: There is substantial evidence that mammalian epithelial stem cells are located within well defined niches. Although the corneoscleral limbus is acknowledged as the site of corneal epithelial stem cells no anatomical niche for such cells has yet been described. The authors undertook to re-evaluate the microanatomy of the limbus in order to identify possible sites that may represent a stem cell niche. METHODS: Systematic serial 5-7 microm sections of human corneoscleral segments obtained from cadaver donors, were examined. The sections were stained with haematoxylin and eosin or toludine blue. Sections with specific areas of interest were further examined immunohistologically for the corneal epithelial marker cytokeratin 14 and the "stem cell" marker ABCG2 transporter protein. RESULTS: Distinct anatomical extensions from the peripheral aspect of the limbal palisades were identified. These consist of a solid cord of cells extending peripherally or circumferentially. The cells stained positive for CK14 and ABCG2. CONCLUSIONS: A novel anatomical structure has been identified at the human limbus, which demonstrates characteristics of being a stem cell niche. The authors have termed this structure the limbal epithelial crypt.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
Goodell, M. A., Brose, K., Paradis, G., Conner, A. S., & Mulligan, R. C. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.4.1797 · Cited by 2,903
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Socializing with the Neighbors
Fuchs, E., Tumbar, T., & Guasch, G. (2004) · Cell · doi:10.1016/s0092-8674(04)00255-7 · Cited by 1,719
Schermer, A., Galvin, S., & Sun, T. T. (1986) · The Journal of cell biology · doi:10.1083/jcb.103.1.49 · Cited by 1,398
p63 identifies keratinocyte stem cells
Pellegrini, G., Dellambra, E., Golisano, O., Martinelli, E., Fantozzi, I., Bondanza, S., Ponzin, D., McKeon, F., & De Luca, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061032098 · Cited by 1,363
Scharenberg, C. W., Harkey, M. A., & Torok-Storb, B. (2002) · Blood · doi:10.1182/blood.v99.2.507 · Cited by 770
Fuchs, E., & Segre, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81691-8 · Cited by 764
Limbal Stem Cells of the Corneal Epithelium
Dua, H. S., & Azuara-Blanco, A. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00109-0 · Cited by 653
Self-citationRole of the Pericorneal Papillary Structure in Renewal of Corneal Epithelium
DAVANGER, M., & EVENSEN, A. (1971) · Nature · doi:10.1038/229560a0 · Cited by 638
Cited by
Progress in corneal wound healing
Ljubimov, A. V., & Saghizadeh, M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.002 · Cited by 872
Niche regulation of corneal epithelial stem cells at the limbus
Li, W., Hayashida, Y., Chen, Y.-T., & Tseng, S. C. (2007) · Cell Research · doi:10.1038/sj.cr.7310137 · Cited by 310
Shortt, A. J., Secker, G. A., Munro, P. M., Khaw, P. T., Tuft, S. J., & Daniels, J. T. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0580 · Cited by 310
Corneal nerves in health and disease
Al-Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.05.003 · Cited by 303
Self-citationCongenital aniridia—A comprehensive review of clinical features and therapeutic approaches
Landsend, E. C. S., Lagali, N., & Utheim, T. P. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2021.02.011 · Cited by 122
Metadata
- Authors
- Dua, H. S.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2005-05-01
- Volume
- 89
- Issue
- 5
- Pages
- 529-532
- ISSN
- 0007-1161 (ISSN-L)
- OpenAlex
- W2168291956
- Cited by
- 391
- References
- 23
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche. https://app.cochat.ai/papers/10.1136/bjo.2004.049742
- The paper
- Dua, H. S. (2005). Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche. British Journal of Ophthalmology. https://doi.org/10.1136/bjo.2004.049742
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
