The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex
Open accessAbstract
The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.
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Cites
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Flagged first, then by citations
Research works printed but not linked: 1
- Yu ¨cel YH, Zhang Q, Gupta N, et al. Loss of neurons in magnocellular and parvocellular layers of the LGN in glaucoma. Arch Ophthalmol 2000;118:378-84.
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Nita, M., & Grzybowski, A. E. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3164734 · Cited by 1,510
The molecular basis of retinal ganglion cell death in glaucoma
Almasieh, M., Wilson, A. M., Morquette, B., Vargas, J. L. C., & Polo, A. D. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.002 · Cited by 990
Definition of glaucoma: clinical and experimental concepts
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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
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Inflammation in Glaucoma: From the back to the front of the eye, and beyond
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Metadata
- Authors
- Gupta, N.
- Affiliations
- St. Michael's Hospital (CA)
- Corresponding author
- Gupta, N
- ORCID
- Gupta, N
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2006-06-01
- Volume
- 90
- Issue
- 6
- Pages
- 674-678
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1860237
- OpenAlex
- W2133684905
- Cited by
- 434
- References
- 21
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 18 · 2023: 11 · 2022: 32 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 17 · 2016: 24 · 2015: 26 · 2014: 22 · 2013: 25 · 2012: 31
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Glaucoma Research Foundation
- Glaucoma Research Society of Canada
- University of Toronto
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
- Keywords
- glaucoma, neurodegeneration, lateral geniculate nucleus, visual cortex, optic nerve head, visual field defects, clinicopathological correlation, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Brain, Female, Geniculate Bodies, Glaucoma, Open-Angle, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Afferent, Optic Nerve, Optic Nerve Diseases, Visual Cortex, Visual Fields, Neurodegenerative Diseases
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