Cited by 384Glaucoma and retinal disordersVisual perception and processing mechanismsDrug-Induced Ocular Toxicity

Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma

Yücel, Y·2003·Progress in Retinal and Eye Research

Abstract

Glaucoma is a leading cause of world blindness, and retinal ganglion cell death is its pathological hallmark. There is accumulating evidence that glaucomatous damage extends from retinal ganglion cells to vision centers in the brain. In an experimental primate model of unilateral glaucoma, degenerative changes are observed in magnocellular, parvocellular, and koniocellular pathways in the lateral geniculate nucleus, and these changes are presented in relation to intraocular pressure and the severity of optic nerve damage. Neuropathological findings are also present in lateral geniculate nucleus layers driven by the unaffected fellow eye. Finally, there is information on changes in the visual cortex in relation to varying degrees of retinal ganglion cell loss. The implications of these findings for refining concepts regarding the pathobiology of progression, and the detection and treatment of glaucoma, are discussed.

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Crossref · 10.1016/s1350-9462(03)00026-0

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89 of 89 references verified0 citation errors · 0 not checkable

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  • Neurodegenerative lesions have been detected in the intracranial optic nerve, lateral geniculate nucleus, and visual cortex in glaucoma, suggesting that glaucoma could be grouped as a neurodegenerative disease.

    “Recently, neurodegenerative lesions have been detected in the intracranial optic nerve, the lateral geniculate nucleus, and the visual cortex (Gupta et al., 2006, 2007), suggesting that this pathology could be grouped as a neurodegenerative disease (Yucel et al., 2003).”

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Authors
Yücel, Y.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Yücel, Y
Venue
Progress in Retinal and Eye Research
Publisher
Elsevier BV
Published
2003-07
Volume
22
Issue
4
Pages
465-481
ISSN
1350-9462 (ISSN-L)
OpenAlex
W1964207930
Cited by
384
References
90
Citations by year
2026: 3 · 2025: 21 · 2024: 13 · 2023: 9 · 2022: 12 · 2021: 19 · 2020: 17 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 20 · 2015: 33 · 2014: 14 · 2013: 20 · 2012: 25
FWCI
12.36
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Retinal and Eye Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute (R01EY002698, EY02698)
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
Keywords
glaucoma, retinal ganglion cell death, lateral geniculate nucleus, visual cortex, magnocellular pathway, parvocellular pathway, koniocellular pathway, intraocular pressure, optic nerve injury
MeSH terms
Animals, Geniculate Bodies, Glaucoma, Humans, Nerve Degeneration, Optic Nerve, Retinal Ganglion Cells, Visual Cortex, Visual Pathways, Cell Death

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