The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy
Abstract
AIMS: The aim of this study was to report the development or progression of tractional retinal detachment (TRD) after the injection of intravitreal bevacizumab (Avastin) used as an adjuvant to vitrectomy for the management of severe proliferative diabetic retinopathy (PDR). METHODS: The clinical charts of patients who experienced the development or progression of TRD after an intravitreal injection of 1.25 mg bevacizumab before vitrectomy for the management of PDR were reviewed. RESULTS: Eleven eyes (patients) out of 211 intravitreal injections (5.2%) that developed or had progression of TRD were identified. All eyes had PDR refractory to panretinal photocoagulation (PRP). Nine patients had type 1 diabetes mellitus (DM), and two patients had type 2 DM. Patients had a mean age of 39.5 years (range 22-62 years). In the current study, all patients used insulin administration and had poor glycaemic control (mean HbA(1c) 10.6%). Time from injection to TRD was a mean of 13 days (range 3-31 days). Mean best correct visual acuity (BCVA) at TRD development or progression was logarithm of the minimal angle of resolution (LogMAR) 2.2 (range 1.0-2.6) (mean Snellen equivalent hand motions; range 20/200 to light perception), a statistically significant worsening compared with baseline BCVA (p<0.0001). Eight eyes underwent vitrectomy and three patients refused or were unable to undergo surgery. The final mean BCVA after surgery was LogMAR 0.9 (range 0.2-2.0) (mean Snellen equivalent 20/160; range 20/32 to counting fingers), a statistically significant improvement compared with TRD BCVA (p = 0.002). CONCLUSIONS: TRD may occur or progress shortly following administration of intravitreal bevacizumab in patients with severe PDR.
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Self-citationDiscovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
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Intravitreal Bevacizumab (Avastin) for Neovascular Age-Related Macular Degeneration
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Intravitreal Bevacizumab (Avastin) in the Treatment of Proliferative Diabetic Retinopathy
Avery, R. L., Pearlman, J., Pieramici, D. J., Rabena, M. D., Castellarin, A. A., Nasir, M. A., Giust, M. J., Wendel, R., & Patel, A. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.05.064 · Cited by 799
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Ghasemi Falavarjani, K., & Nguyen, Q. D. (2013) · Eye · doi:10.1038/eye.2013.107 · Cited by 982
Diabetic Retinopathy Preferred Practice Pattern®
Flaxel, C. J., Adelman, R. A., Bailey, S. T., Fawzi, A., Lim, J. I., Vemulakonda, G. A., & Ying, G.-S. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2019.09.025 · Cited by 717
Optical coherence tomography: Imaging of the choroid and beyond
Mrejen, S., & Spaide, R. F. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.12.001 · Cited by 477
Tan, G. S., Cheung, N., Simó, R., Cheung, G. C. M., & Wong, T. Y. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30052-3 · Cited by 361
Ocular complications of diabetes mellitus
Sayin, N. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i1.92 · Cited by 358
Metadata
- Authors
- Arevalo, J. F., Maia, M., Flynn, H. W., Saravia, M., Avery, R. L., Wu, L., Farah, M. E., Pieramici, D. J., Berrocal, M. H., & Sanchez, J. G.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2007-10-26
- Volume
- 92
- Issue
- 2
- Pages
- 213-216
- ISSN
- 0007-1161 (ISSN-L)
- OpenAlex
- W2105913241
- Cited by
- 411
- References
- 18
- FWCI
- 24.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Arevalo, J. F., Maia, M., Flynn, H. W., Saravia, M., Avery, R. L., Wu, L., Farah, M. E., Pieramici, D. J., Berrocal, M. H., & Sanchez, J. G. (2008). Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy. British Journal of Ophthalmology. https://doi.org/10.1136/bjo.2007.127142
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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