Type IV collagen and laminin in Bruch’s membrane and basal linear deposit in the human macula

Marshall, G E; Konstas, A G; Reid, G G; Edwards, J G; Lee, W R

doi:10.1136/bjo.76.10.607

Cited by 84Retinal Diseases and TreatmentsRetinal and Macular SurgeryRetinal Development and Disorders

Type IV collagen and laminin in Bruch’s membrane and basal linear deposit in the human macula

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Marshall, G E, Konstas, A G, Reid, G G, Edwards, J G, Lee, W R·1992·British Journal of Ophthalmology

DOI 10.1136/bjo.76.10.607PMC PMC505233

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Abstract

Tissue obtained from the macula in 10 human eyes (53-77 years) was used for an investigation into the extracellular matrices of the retinal pigment epithelium (RPE), Bruch's membrane, and the choriocapillaris. The ultrastructural distribution of type IV collagen and laminin was documented using immunogold labelling. Labelling for type IV collagen was strongly positive in all the specimens in the basement membranes of the choriocapillaris but not that of the RPE where labelling was either weak or absent. Laminin was localised to deposits of granular material in Bruch's membrane but was absent from the basement membrane of the RPE and the choriocapillaris. Basal linear deposit, observed in three cases, demonstrated labelling for laminin but not for type IV collagen. The series was too small for correlation of these morphological changes with age.

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Immunolabeling with antibodies against elastin and collagen IV shows no significant difference between Klc1−/− and control, suggesting that these regions of Bruch's membrane are relatively unaffected.
“Immunolabeling with antibodies against elastin and collagen IV, which are present in the elastin layer and choroidal basement membrane of Bruch’s membrane, respectively (Marshall et al., 1992), showed no significant difference between mutant and control, suggesting that these regions of Bruch’s membrane were relatively unaffected.”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Marshall et al., 1992

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Authors: Marshall, G. E., Konstas, A. G., Reid, G. G., Edwards, J. G., & Lee, W. R.
Affiliations: University of Glasgow (GB)
ORCID: Konstas, A G
Venue: British Journal of Ophthalmology
Publisher: BMJ
Published: 1992-10-01
Volume: 76
Issue: 10
Pages: 607-614
ISSN: 0007-1161 (ISSN-L)
DOI: 10.1136/bjo.76.10.607
PMC: PMC505233
OpenAlex: W2049669592
Cited by: 84
References: 43
Citations by year: 2025: 5 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 5
FWCI: 2.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: British Journal of Ophthalmology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords: type IV collagen, laminin, Bruch's membrane, macula, retinal pigment epithelium, choriocapillaris, basement membrane, extracellular matrix, immunogold labeling, ultrastructure
MeSH terms: Aged, Choroid, Collagen, Female, Humans, Laminin, Macula Lutea, Male, Microscopy, Electron, Middle Aged, Pigment Epithelium of Eye, Bruch Membrane

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Type IV collagen and laminin in Bruch’s membrane and basal linear deposit in the human macula

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