Bruch’s membrane age-related changes vary by region
Abstract
Aging changes known to occur in Bruch's membrane may be associated with drusen formation and retinal pigment epithelial mottling, which often have a peripheral as well as a macular distribution. Few details of peripheral Bruch's membrane aging changes have been reported. We conducted a histochemical investigation of Bruch's membrane in 31 postmortem donor eyes and an ultrastructural morphometric investigation of these regional changes in a subgroup of 22 eyes. The age of our donors ranged from 12 days to 80 years. When we reacted 5 micron paraffin embedded sections of chorio-retinal complex fixed in 2% glutaraldehyde-1% paraformaldehyde, we observed increased PAS positivity, and staining with Weigert's elastin and alcian blue at pH 2.5 in Bruch's membranes from donors over 46 years. In this older group, the macula showed increased histochemical reactivity for glycoconjugates, glycosaminoglycans, collagen and elastin as compared with the equator and periphery. Thickening of Bruch's membrane was first detected in the periphery in tissue from donors aged 10 to 45. Thickening of macular Bruch's membrane was first detected in tissue from donors older than 45. The major proportion of thickening, which appears to be due to the deposition of fibrillar and amorphous material, occurred earlier in the inner than the outer collagenous zone. The equatorial region was relatively spared. Our findings confirm and extend the observations of the timing, regional predeliction, and extent of Bruch's membrane aging changes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BrM undergoes thickening with ageing, detectable using modern ophthalmic imaging.
“BrM undergoes thickening with ageing [29,45,46,47], detectable using modern ophthalmic imaging (Figure 2).”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [29]
Cites
Ageing and degeneration in the macular region: A clinico-pathological study
Sarks, S. H. (1976) · British Journal of Ophthalmology · doi:10.1136/bjo.60.5.324 · Cited by 891 · see citing works
Drusen and Disciform Macular Detachment and Degeneration
Gass, J. D. M. (1973) · Archives of Ophthalmology · doi:10.1001/archopht.1973.01000050208006 · Cited by 593 · see citing works
SENILE MACULAR DEGENERATION: A HISTOPATHOLOGIC STUDY*
Green, W. R., & Key, S. N. (2005) · Retina · doi:10.1097/00006982-200507001-00005 · Cited by 322 · see citing works
Self-citationPathologic Features of Senile Macular Degeneratlon
Green, W. R., McDonnell, P. J., & Yeo, J. H. (1985) · Ophthalmology · doi:10.1016/s0161-6420(85)33993-3 · Cited by 320 · see citing works
Self-citationPathologic Features of Senile Macular Degeneration
GREEN, W. R., McDonnell, P. J., & Yeo, J. H. (2005) · Retina · doi:10.1097/00006982-200507001-00011 · Cited by 315 · see citing works
Self-citationDRUSEN AND THEIR RELATIONSHIP TO SENILE MACULAR DEGENERATION
Sarks, S. H. (1980) · Australian and New Zealand Journal of Ophthalmology · doi:10.1111/j.1442-9071.1980.tb01670.x · Cited by 219 · see citing works
Age-Related Changes in the Ultrastructure of Bruch's Membrane
Feeney-Burns, L., & Ellersieck, M. R. (1985) · American Journal of Ophthalmology · doi:10.1016/0002-9394(85)90625-7 · Cited by 207 · see citing works
Hogan, M. J. (1967) · Archives of Ophthalmology · doi:10.1001/archopht.1967.00980020412022 · Cited by 116 · see citing works
Farkas, T. G., Sylvester, V., Archer, D., & Altona, M. (1971) · American Journal of Ophthalmology · doi:10.1016/0002-9394(71)90964-0 · Cited by 112 · see citing works
Ageing changes in Bruch's membrane and their functional implications.
Cf, G., & Marshall, J.-C. (1978) · PubMed · Cited by 111 · see citing works
Senile Disciform Degeneration of the Macula
Green, W. R. (1971) · Archives of Ophthalmology · doi:10.1001/archopht.1971.01000010489001 · Cited by 94 · see citing works
Self-citationCollagen production in vitro by the retinal pigmented epithelium of the chick embryo
Newsome, D. A., & Kenyon, K. R. (1973) · Developmental Biology · doi:10.1016/0012-1606(73)90249-2 · Cited by 84 · see citing works
Self-citationBruch's membrane and disease of the macula. Role of elastic tissue and collagen.
Mj, H. (1967) · PubMed · Cited by 83 · see citing works
The Retinal Pigment Epithelium
Friedman, E. (1968) · Archives of Ophthalmology · doi:10.1001/archopht.1968.03850040317017 · Cited by 79 · see citing works
HISTOLOGICAL FINDINGS IN A CASE OF ANGIOID STREAKS
VERHOEFF, F. H. (1948) · British Journal of Ophthalmology · doi:10.1136/bjo.32.9.531 · Cited by 62 · see citing works
Garron, L. K. (1963) · PubMed · Cited by 59 · see citing works
Wislocki, G. B., & Ladman, A. J. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.6.501 · Cited by 46 · see citing works
The Ultrastructure of Bruch's Membrane
NAKAIZUMI, Y. (1964) · Archives of Ophthalmology · doi:10.1001/archopht.1964.00970020395018 · Cited by 45 · see citing works
Newsome, D. A., Pfeffer, B. A., Hewitt, A. T., Robey, P. G., & Hassell, J. R. (1988) · Experimental Eye Research · doi:10.1016/s0014-4835(88)80022-8 · Cited by 44 · see citing works
Self-citationUltrastructure of Bruch's Membrane After Krypton Laser Photocoagulation
Pollack, A. (1986) · Archives of Ophthalmology · doi:10.1001/archopht.1986.01050210131040 · Cited by 43 · see citing works
Lewis, H., Straatsma, B. R., & Foos, R. Y. (1986) · Ophthalmology · doi:10.1016/s0161-6420(86)33615-7 · Cited by 39 · see citing works
Foos, R. Y. (1982) · Archives of Ophthalmology · doi:10.1001/archopht.1982.01030040470020 · Cited by 38 · see citing works
Reticular Degeneration of the Pigment Epithelium
Lewis, H., Straatsma, B. R., Foos, R. Y., & Lightfoot, D. O. (1985) · Ophthalmology · doi:10.1016/s0161-6420(85)33829-0 · Cited by 36 · see citing works
Beiträge zur Anatomie und Histologie der Aderhaut beim Menschen und bei höheren Wirbeltieren
Wolfrum, M. (1908) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf02229788 · Cited by 35 · see citing works
Altered synthesis of Bruch's membrane proteoglycans associated with dominant retinitis pigmentosa
Hewitt, A. T., & Newsome, D. A. (1985) · Current Eye Research · doi:10.3109/02713688509000846 · Cited by 35 · see citing works
Self-citationCERTAIN RETINOPATHIES DUE TO CHANGES IN THE LAMINA VITREA
Gifford, S. R., & Cushman, B. (1940) · Archives of Ophthalmology · doi:10.1001/archopht.1940.00860130072007 · Cited by 21 · see citing works
Age changes in the fine structure of the human retinal pigment epithelium
Mishima, H. K., Hasebe, H., & Kondo, K. (1978) · Japanese Journal of Ophthalmology · Cited by 19 · see citing works
Pathology of macular degeneration in the elderly.
Garner, A. (1975) · PubMed · Cited by 11 · see citing works
The fine structure of Bruch's membrane in the human eye.
Mj, H., & Wl, B. (1969) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Current concepts in the pathogenesis of age-related macular degeneration
Zarbin, M. A. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.598 · Cited by 1,006 · see citing works
Mullins, R. F., Russell, S. R., Anderson, D. H., & Hageman, G. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.835 · Cited by 937 · see citing works
Owsley, C. J. (2010) · Vision Research · doi:10.1016/j.visres.2010.10.020 · Cited by 718 · see citing works
Para-Inflammation in the Aging Retina
Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · see citing works
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 633 · see citing works
The dynamic nature of Bruch's membrane
Booij, J. C., Baas, D. C., Beisekeeva, J., Gorgels, T. G. M. F., & Bergen, A. A. B. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.003 · Cited by 581 · see citing works
Accumulation of cholesterol with age in human Bruch's membrane.
Curcio, C. A., Millican, C. L., Bailey, T. A., & Kruth, H. S. (2001) · PubMed · Cited by 442 · see citing works
The association of cardiovascular disease with the long-term incidence of age-related maculopathy
Klein, R., Klein, R., Tomany, S. C., & Cruickshanks, K. J. (2003) · Ophthalmology · doi:10.1016/s0161-6420(02)01448-3 · Cited by 339 · see citing works
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Curcio, C. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24882 · Cited by 319 · see citing works
Age‐related Macular Degeneration (AMD)
(2008) · Springer eBooks · doi:10.1007/978-3-540-38918-7_5059 · Cited by 322 · see citing works
Transplantation of the RPE in AMD
Binder, S., Stanzel, B. V., Krebs, I., & Glittenberg, C. G. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.02.002 · Cited by 292 · see citing works
Age-related variation in the hydraulic conductivity of Bruch's membrane.
Moore, D., Hussain, A., & Marshall, J. (1995) · PubMed · Cited by 288 · see citing works
Epidemiology of Age-Related Macular Degeneration
Klein, R. (2005) · Springer eBooks · doi:10.1007/3-540-26977-0_5 · Cited by 287 · see citing works
Spraul, C. W., Lang, G., Grossniklaus, H. E., & Lang, G. K. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00086-7 · Cited by 258 · see citing works
A comparison of some organizational characteristics of the mouse central retina and the human macula
Volland, S., Esteve-Rudd, J., Hoo, J., Yee, C., & Williams, D. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125631 · Cited by 229 · see citing works
Chong, N. H. V., Keonin, J., Luthert, P. J., Frennesson, C. I., Weingeist, D. M., Wolf, R. L., Mullins, R. F., & Hageman, G. S. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62248-1 · Cited by 218 · see citing works
The association of cardiovascular disease with the long-term incidence of age-related maculopathy
Klein, R., Klein, B. E. K., Tomany, S. C., & Cruickshanks, K. J. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00599-2 · Cited by 209 · see citing works
Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration
Provis, J. M., Penfold, P. L., Cornish, E. E., Sandercoe, T. M., & Madigan, M. C. (2005) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2005.tb06711.x · Cited by 200 · see citing works
Age-related changes in human RPE cell density and apoptosis proportion in situ.
Priore, L. V. D., Kuo, Y.-H., & Tezel, T. H. (2002) · PubMed · Cited by 191 · see citing works
Owsley, C. J. (2016) · Annual Review of Vision Science · doi:10.1146/annurev-vision-111815-114550 · Cited by 183 · see citing works
Fields, M. A., Priore, L. V. D., Adelman, R. A., & Rizzolo, L. J. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100803 · Cited by 172 · see citing works
Structure, Function, and Pathology of Bruch's Membrane
Curcio, C. A., & Johnson, M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00020-5 · Cited by 169 · see citing works
Spraul, C. W. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150269022 · Cited by 168 · see citing works
Changes in Bruch’s membrane and related structures with age
Guymer, R. H., Luthert, P. J., & Bird, A. C. (1999) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(98)00012-3 · Cited by 162 · see citing works
Mechanism of Inflammation in Age-Related Macular Degeneration
Parmeggiani, F., Romano, M., Costagliola, C., Semeraro, F., Incorvaia, C., D’Angelo, S., Perri, P., Palma, P. D., Nadai, K. D., & Sebastiani, A. (2012) · Mediators of Inflammation · doi:10.1155/2012/546786 · Cited by 135 · see citing works
Peripapillary chorioretinal atrophy
Curcio, C. A., Saunders, P. L., Younger, P. W., & Malek, G. (2000) · Ophthalmology · doi:10.1016/s0161-6420(99)00037-8 · Cited by 129 · see citing works
Curcio, C. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24883 · Cited by 127 · see citing works
Pilgrim, M. G., Lengyel, I., Lanzirotti, A., Newville, M. G., Fearn, S., Emri, E., Knowles, J. C., Messinger, J. D., Read, R. W., Guidry, C., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-21060 · Cited by 120 · see citing works
Localization of the site of major resistance to fluid transport in Bruch's membrane.
Starita, C., Hussain, A. A., Patmore, A., & Marshall, J. (1997) · PubMed · Cited by 113 · see citing works
Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etch
Huang, J.-D., Presley, J. B., Chimento, M. F., Curcio, C. A., & Johnson, M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.03.011 · Cited by 102 · see citing works
Das, A. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070050119045 · Cited by 98 · see citing works
Reattachment Rate of Human Retinal Pigment Epithelium to Layers of Human Bruch's Membrane
Priore, L. V. D. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.3.335 · Cited by 94 · see citing works
Bruch′s membrane thickness in high myopia
Jonas, J. B., Holbach, L. M., & Panda‐Jonas, S. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12372 · Cited by 92 · see citing works
The spectrum of phenotypes caused by variants in the CFH gene
Boon, C. J. F., van de Kar, N. C. A. J., Klevering, B. J., KEUNEN, J. E. E., Cremers, F. P. M., Klaver, C. C. W., Hoyng, C. B., Daha, M. R., & den Hollander, A. I. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.02.013 · Cited by 91 · see citing works
Tezel, T. H., & Priore, L. V. D. (1999) · PubMed · Cited by 89 · see citing works
Owsley, C., McGwin, G., Jackson, G. R., Heimburger, D. C., Piyathilake, C. J., Klein, R., White, M. F., & Kallies, K. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1292 · Cited by 85 · see citing works
Type IV collagen and laminin in Bruch’s membrane and basal linear deposit in the human macula
Marshall, G. E., Konstas, A. G., Reid, G. G., Edwards, J. G., & Lee, W. R. (1992) · British Journal of Ophthalmology · doi:10.1136/bjo.76.10.607 · Cited by 84 · see citing works
Hussain, A. A., Rowe, L., & Marshall, J. (2002) · Journal of the Optical Society of America A · doi:10.1364/josaa.19.000166 · Cited by 77 · see citing works
Kaarniranta, K., & Salminen, A. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0418-z · Cited by 75 · see citing works
Fernández‐Godino, R., Bujakowska, K. M., & Pierce, E. A. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx392 · Cited by 71 · see citing works
Cuticular drusen: Stars in the sky
Boon, C. J. F., van de Ven, J. P. H., Hoyng, C. B., den Hollander, A. I., & Klevering, B. J. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.08.003 · Cited by 70 · see citing works
Gottsch, J. D., Pou, S., Bynoe, L. A., & Rosen, G. M. (1990) · PubMed · Cited by 68 · see citing works
Sorkio, A., Hongisto, H., Kaarniranta, K., Uusitalo, H. M. T., Juuti‐Uusitalo, K., & Skottman, H. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0049 · Cited by 67 · see citing works
Layer, P., & Willbold, E. (1989) · Cell and Tissue Research · doi:10.1007/bf00239443 · Cited by 65 · see citing works
Ahir, A., Guo, L., Hussain, A. A., & Marshall, J. (2002) · PubMed · Cited by 64 · see citing works
Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane
Murdaugh, L. S., Wang, Z., Priore, L. V. D., Dillon, J. P., & Gaillard, E. R. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.01.014 · Cited by 59 · see citing works
Miceli, M., Newsome, D., Tate, D., & Sarphie, T. G. (2000) · Current Eye Research · doi:10.1076/0271-3683(200001)2011-hft008 · Cited by 18 · see citing works
Self-citationLong-Term Blood Pressure and Age-Related Macular Degeneration: The ALIENOR Study
Cougnard‐Grégoire, A., Delyfer, M., Korobelnik, J., Rougier, M., Malet, F., Goff, M. L., Dartigues, J., Colin, J., Barberger‐Gateau, P., & Delcourt, C. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10192 · Cited by 57 · see citing works
Collagens in the aged human macula
Marshall, G. E., Konstas, A. G. P., Reid, G., Edwards, J. G., & Lee, W. R. (1994) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00176781 · Cited by 56 · see citing works
Light-Induced Deposits in Bruch's Membrane of Protoporphyric Mice
Gottsch, J. D. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090010130039 · Cited by 53 · see citing works
Fitzgerald, M. E. C., Tolley, E. A., Frase, S., Zagvazdin, Y., MILLER, R. F., Hodos, W., & Reiner, A. J. (2001) · Visual Neuroscience · doi:10.1017/s0952523801182143 · Cited by 50 · see citing works
Hillenkamp, J. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0765 · Cited by 49 · see citing works
Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
Newsome, D. A., Pfeffer, B. A., Hewitt, A. T., Robey, P. G., & Hassell, J. R. (1988) · Experimental Eye Research · doi:10.1016/s0014-4835(88)80022-8 · Cited by 44 · see citing works
Self-citationBruch´s membrane thickness in relationship to axial length
Bai, H. X., Mao, Y. Y., Shen, L., Xu, X. L., Gao, F., Zhang, Z. B., Li, B., & Jonas, J. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182080 · Cited by 42 · see citing works
Paimela, T., Hyttinen, J. M. T., Viiri, J., Ryhänen, T., Karjalainen, R., Salminen, A., & Kaarniranta, K. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.05.027 · Cited by 42 · see citing works
Age-Dependent Change in the Hyaluronic Acid Content of the Human Chorioretinal Complex
Tate, D. J. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090070083023 · Cited by 35 · see citing works
Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.10.008 · Cited by 33 · see citing works
Analysis of the Collagen VI Assemblies Associated with Sorsby's Fundus Dystrophy
Knupp, C., Chong, V. N., Munro, P., Luthert, P. J., & Squire, J. M. (2002) · Journal of Structural Biology · doi:10.1006/jsbi.2002.4449 · Cited by 30 · see citing works
Wang, Z., Paik, D. C., Priore, L. V. D., Scholar, R. L. B. I., & Gaillard, E. R. (2005) · Current Eye Research · doi:10.1080/02713680590968259 · Cited by 26 · see citing works
BCLA CLEAR presbyopia: Mechanism and optics
Davies, L. N., Biswas, S., Bullimore, M. A., Cruickshank, F. E., Estevez, J. J., Khanal, S., Kollbaum, P. S., Marcotte-Collard, R., Montani, G., Plainis, S., et al. (2024) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2024.102185 · Cited by 24 · see citing works
Khan, K. N., Borooah, S., Landó, L., Dans, K., Mahroo, O. A., Meshi, A., Kalitzeos, A. A., Agorogiannis, G., Moghimi, S., Freeman, W. R., et al. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.6.26 · Cited by 21 · see citing works
Measurement of TIMP-3 Expression and Bruch's Membrane Thickness in Human Macula
Bailey, T. A., Alexander, R., Dubovy, S. R., Luthert, P. J., & Chong, V. N. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1089 · Cited by 19 · see citing works
Miceli, M. V., & Newsome, D. A. (1996) · Current Eye Research · doi:10.3109/02713689609017607 · Cited by 19 · see citing works
Self-citationImmunogold localization of extracellular matrix molecules in Bruch's membrane of the rat
Lin, W. (1989) · Current Eye Research · doi:10.3109/02713688909000042 · Cited by 18 · see citing works
Mechanobiological implications of age-related remodelling in the outer retina
Piskova, T., Kozyrina, A. N., & Russo, J. D. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213343 · Cited by 17 · see citing works
Bruch's Membrane Calcification in Pseudoxanthoma Elasticum
Risseeuw, S., Pilgrim, M. G., Bertazzo, S., Brown, C. N., Csincsik, L., Fearn, S., Thompson, R. B., Bergen, A. A. B., ten Brink, J. B., Körtvely, E., et al. (2023) · Ophthalmology Science · doi:10.1016/j.xops.2023.100416 · Cited by 17 · see citing works
Capillaries are present in Bruch's membrane at the ora serrata in the human eye.
Schraermeyer, U., Addicks, K., Kociok, N., Esser, P., & Heimann, K. (1998) · PubMed · Cited by 17 · see citing works
Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE
Peters, F., Ebner, L. J. A., Atac, D., Maggi, J., Berger, W., den Hollander, A. I., & Grimm, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063194 · Cited by 16 · see citing works
The Natural History of Bruch’s Membrane Calcification in Pseudoxanthoma Elasticum
Risseeuw, S., van Leeuwen, R., Imhof, S. M., Spiering, W., & Norel, J. O. (2021) · Ophthalmology Science · doi:10.1016/j.xops.2020.100001 · Cited by 15 · see citing works
The choroid-sclera interface: An ultrastructural study
Platzl, C., Kaser-Eichberger, A., Benavente-Pérez, A., & Schroedl, F. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09408 · Cited by 12 · see citing works
Murdaugh, L. S., Dillon, J. P., & Gaillard, E. R. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.03.021 · Cited by 12 · see citing works
Rickabaugh, E., Weatherston, D., Harris, T. I., Jones, J. A., & Vargis, E. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00411 · Cited by 11 · see citing works
Chong, V. N., Keonin, J., Luthert, P. J., Frennesson, C. I., Weingeist, D. M., Wolf, R. L., Mullins, R. F., & Hageman, G. S. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.04.005 · Cited by 11 · see citing works
Retinal Biochemistry, Physiology and Cell Biology
Smith, R. L., Sivaprasad, S., & Chong, V. N. (2015) · Developments in ophthalmology · doi:10.1159/000431118 · Cited by 10 · see citing works
Laminin-defined mechanical status modulates retinal pigment epithelium phagocytosis
Kozyrina, A. N., Piskova, T., Semeraro, F., Doolaar, I. C., Prapty, T., Haraszti, T., Hubert, M., Windoffer, R., Leube, R. E., Smith, A., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00475-9 · Cited by 10 · see citing works
The peripheral and Central Humphrey visual field – morphological changes during aging
Rutkowski, P. C., & May, C. A. (2017) · BMC Ophthalmology · doi:10.1186/s12886-017-0522-3 · Cited by 10 · see citing works
Hadrian, K., Melkonyan, H., Schlatt, S., Wistuba, J., Wasmuth, S., Heiligenhaus, A., Thanos, S., & Böhm, M. R. R. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.05.016 · Cited by 10 · see citing works
Chapter 59 – Age Changes in Bruch's Membrane and Related Structures
Guymer, R., & Bird, A. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-02598-0.50065-3 · Cited by 7 · see citing works
Ong, J., Selvam, A., Driban, M., Zarnegar, A., Silva, S. I. M. M. A. D., Joy, J. G., Rossi, E. A., Geest, J. P. V., Sahel, J., & Chhablani, J. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101358 · Cited by 9 · see citing works
Watching the human retina breath in real time and the slowing of mitochondrial respiration with age
Kaynezhad, P., Tachtsidis, I., Sivaprasad, S., & Jeffery, G. (2023) · Scientific Reports · doi:10.1038/s41598-023-32897-7 · Cited by 9 · see citing works
Chronologic versus Biologic Aging of the Human Choroid
May, C. A. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/378206 · Cited by 8 · see citing works
Ex Vivo Confocal Spectroscopy of Autofluorescence in Age-Related Macular Degeneration
Kaluzny, J. V., Purta, P., Poskin, Z., Rogers, J. D., & Fawzi, A. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162869 · Cited by 7 · see citing works
The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up
Salobrar‐García, E., Ramirez, A. I., de Hoz, R., Rojas, P., Salazar, J. J., Rojas, B., Yubero, R., Gil, P., Triviño, A., & Ramirez, J. M. (2016) · InTech eBooks · doi:10.5772/64490 · Cited by 8 · see citing works
Jafari, S., Cai, S., & Demer, J. L. (2025) · Bioengineering · doi:10.3390/bioengineering12060587 · Cited by 6 · see citing works
Thananjeyan, A. L., Arnold, J., Lee, M. B., Au, C. P., Pye, V. J., Madigan, M. C., & Cherepanoff, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164611 · Cited by 6 · see citing works
Systemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies
Villafuerte-Trisolini, C., Le, S. M., Sin, T.-N., Huynh, L., Gong, M., Shen, T., Heo, J., Roszak, K. P., Raposo, A. C. S., Graham, J., et al. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.12.41 · Cited by 5 · see citing works
Grenell, A., Singh, C., Raju, M., Wolk, A., Dalvi, S., Jang, G.-F., Crabb, J. S., Hershberger, C. E., Manian, K. V., Hernandez, K. N., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101995 · Cited by 5 · see citing works
DiLoreto, D. A., Luo, C., Calkins, D. J., & del Cerro, M. (2006) · Current Eye Research · doi:10.1080/02713680600864782 · Cited by 5 · see citing works
Large drusen following long-standing retinal detachment
Babu, K., Prabhakaran, V., & Shenoy, S. (2010) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.64316 · Cited by 4 · see citing works
Choroidal endothelial cell activation in age-related macular degeneration
Skeie, J. M. (2010) · doi:10.17077/etd.rqzkgl09 · Cited by 4 · see citing works
LoBue, S., Yamada, N., Choi, M. J., & Olsen, T. W. (2017) · Translational Vision Science & Technology · doi:10.1167/tvst.6.6.5 · Cited by 3 · see citing works
Bruch’s Membrane: The Critical Boundary in Macular Degeneration
Mullins, R. F., & Elliott, H. (2012) · InTech eBooks · doi:10.5772/31370 · Cited by 2 · see citing works
Hypothesis: Watershed zones in the human eye are a key for understanding glaucomatous retinal damage
May, C. A., & Rutkowski, P. C. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.009 · Cited by 2 · see citing works
Sundstrom, J. M., Weber, S. R., Zhou, M., & Hogan, R. N. (2022) · Springer eBooks · doi:10.1007/978-3-030-42634-7_305 · Cited by 2 · see citing works
Aspects of the senescent lens and retina
Weale, R. A. (1992) · Reviews in Clinical Gerontology · doi:10.1017/s095925980000294x · Cited by 2 · see citing works
Heyward, J. L., Dubielzig, R. R., Ray, C., Teixeira, L. B. C., & Mowat, F. M. (2025) · Veterinary Pathology · doi:10.1177/03009858251367410 · Cited by 1 · see citing works
The elephant retina examined across a range of agesPreprint
Freed, J., Joyce, S., Whalley, R., Purse, E., Ingram, T. L., Yon, L., & Chakrabarti, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.20.427452 · Cited by 1 · see citing works
Function and pathology of the human retinal pigment epithelium
Booij, J. C. (2010) · UvA-DARE (University of Amsterdam)
Hogan, R. N. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-0016-7.50340-4
- Authors
- Newsome, D. A., Huh, W., & Green, W. R.
- Affiliations
- Johns Hopkins University (US)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Venue
- Current Eye Research
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 6
- Issue
- 10
- Pages
- 1211-1221
- ISSN
- 0271-3683 (ISSN-L)
- 1460-2202
- OpenAlex
- W1980685924
- Cited by
- 105
- References
- 31
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- National Eye Institute (EY06677, EY-02377)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Bruch's membrane, aging, regional variation, drusen, macula, periphery, collagen deposition, elastin, glycosaminoglycans, glycoconjugates, ultrastructural morphometry
- MeSH terms
- Adolescent, Adult, Aged, Aging, Child, Choroid, Histocytochemistry, Humans, Microscopy, Electron, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
