Causes and frequency of blindness in patients with intraocular inflammatory disease.
Open accessAbstract
AIMS/BACKGROUND: Uveitis, an intraocular inflammatory disease, is a significant cause of visual impairment. It is not known how many patients with uveitis will retain visual acuity and how many develop visual impairment or even blindness. The aim of this study was to assess the frequency of blindness in patients with uveitis and, more specifically, to identify the clinical profile of patients at risk for visual loss. METHODS: A cross sectional and retrospective study of 582 patients with uveitis who visited the ophthalmology departments of two university hospitals in the Netherlands was performed. RESULTS: Within the group of 582 patients, 203 (35%) exhibited blindness or visual impairment; bilateral legal blindness developed in 22 (4%) patients, 26 (4.5%) had one blind eye with visual impairment of the other, and nine (1.5%) had bilateral visual impairment. Unilateral blindness developed in 82 (14%) patients, whereas 64 (11%) exhibited unilateral visual impairment. The most important cause of both blindness and visual impairment was cystoid macular oedema (29% and 41%, respectively). Complications of uveitis were encountered in more than half of the patients and 23% underwent one or more surgical procedures. When the patients were subdivided according to anatomical site, those with panuveitis had the worst visual prognosis. The systemic diseases associated with a poor visual prognosis were juvenile chronic arthritis and sarcoidosis. Ocular toxoplasmosis was the most frequent cause of unilateral visual loss. CONCLUSIONS: Cystoid macular oedema is the most frequent complication of uveitis and its occurrence plays a decisive role in the visual outcome of this disease.
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Intraocular inflammation remains a major cause of vision loss.
“Yet, despite immune privilege, intraocular inflammation remains a major cause of vision loss—underscoring the limitations of our current understanding of the phenomenon.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [13]
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Cites
Bloch-Michel, E., & Nussenblatt, R. B. (1987) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)74235-7 · Cited by 731 · see citing works
The natural history of uveitis
Nussenblatt, R. B. (1990) · International Ophthalmology · doi:10.1007/bf00163549 · Cited by 514 · see citing works
Development of Adverse Sequelae in Children Born with Subclinical Congenital Toxoplasma Infection
Wilson, C. B., Remington, J. S., Stagno, S., et al. (1980) · PEDIATRICS · doi:10.1542/peds.66.5.767 · Cited by 456 · see citing works
Principles and Practice of Ophthalmology
Mannis, M. J. (1994) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)73166-6 · Cited by 418 · see citing works
Mcauley, J. B., Boyer, K. M., Patel, D. V., et al. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.1.38 · Cited by 401 · see citing works
Rothová, A., Buitenhuis, H. J., Meenken, C., et al. (1992) · British Journal of Ophthalmology · doi:10.1136/bjo.76.3.137 · Cited by 328 · see citing works
Ryan, S. J., & Maumenee, A. E. (1980) · American Journal of Ophthalmology · doi:10.1016/0002-9394(80)90226-3 · Cited by 279 · see citing works
Toxoplasmosis: the Time Has Come
McCabe, R. E., & Remington, J. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802043180509 · Cited by 248 · see citing works
Clinical Features of Acute Anterior Uveitis
Rothová, A., van Veenendaal, W. G., Linssen, A., Glasius, E., Kijlstra, A., & de Jong, P. T. V. M. (1987) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)74218-7 · Cited by 229 · see citing works
Self-citationSeverity of Scleritis and Episcleritis
de la Maza, M. S., Jabbur, N. S., & Foster, C. S. (1994) · Ophthalmology · doi:10.1016/s0161-6420(94)31325-x · Cited by 214 · see citing works
Prognostic Factors in the Uveitis of Juvenile Rheumatoid Arthritis
Wolf, M. D., Lichter, P. R., & Ragsdale, C. G. (1987) · Ophthalmology · doi:10.1016/s0161-6420(87)80007-6 · Cited by 205 · see citing works
Birdshot chorioretinopathy: clinical characteristics and evolution.
Priem, H., & Oosterhuis, J. A. (1988) · British Journal of Ophthalmology · doi:10.1136/bjo.72.9.646 · Cited by 179 · see citing works
Risk factors for ocular sarcoidosis
Rothová, A., Alberts, C., Glasius, E., et al. (1989) · Documenta Ophthalmologica · doi:10.1007/bf00153496 · Cited by 134 · see citing works
Posterior Segment Ocular Manifestations in Patients with HLA-B27—associated Uveitis
Rodríguez-García, A., Akova, Y. A., Pedroza-Seres, M., & Foster, C. S. (1994) · Ophthalmology · doi:10.1016/s0161-6420(94)31179-1 · Cited by 130 · see citing works
The Rate of Visual Loss in Behcet's Disease
Mamo, J. G. (1970) · Archives of Ophthalmology · doi:10.1001/archopht.1970.00990040453009 · Cited by 130 · see citing works
Evaluation of the Possibilities for Preventing Congenital Toxoplasmosis
Foulon, W., Naessens, A., & Derde, M. P. (1994) · American Journal of Perinatology · doi:10.1055/s-2007-994537 · Cited by 118 · see citing works
Detection of Intraocular Antibody Production to Herpesviruses in Acute Retinal Necrosis Syndrome
de Boer, J. H., Luyendijk, L., Rothová, A., et al. (1994) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)73077-6 · Cited by 113 · see citing works
The Clinical Course of Serpiginous Choroidopathy
WEISS, H., Annesley, W. H., Shields, J. A., et al. (1979) · American Journal of Ophthalmology · doi:10.1016/0002-9394(79)90131-4 · Cited by 96 · see citing works
Forrester, J. V. (1991) · The Lancet · doi:10.1016/0140-6736(91)92309-p · Cited by 95 · see citing works
A FOLLOW‐UP STUDY ON SERPIGINOUS CHOROIDITIS
Laatikainen, L., & Erkkilä, H. (1981) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1981.tb08737.x · Cited by 81 · see citing works
Long-term results of pars plana vitrectomy in the management of complicated uveitis.
Heiligenhaus, A., Bornfeld, N., Foerster, M. H., et al. (1994) · British Journal of Ophthalmology · doi:10.1136/bjo.78.7.549 · Cited by 79 · see citing works
Causes of blindness in The Netherlands
Doesschate, J. T. (1982) · Documenta Ophthalmologica · doi:10.1007/bf01675857 · Cited by 58 · see citing works
Serology in ocular toxoplasmosis.
Rothová, A., Knapen, F. V., Baarsma, G. S., et al. (1986) · British Journal of Ophthalmology · doi:10.1136/bjo.70.8.615 · Cited by 55 · see citing works
Fluorescein Angiography of Peripheral Uveitis
Pruett, R. C., Brockhurst, R. J., & Letts, N. F. (1974) · American Journal of Ophthalmology · doi:10.1016/0002-9394(74)90452-8 · Cited by 47 · see citing works
Blindness from uveitis in a hospital population in Sierra Leone.
Ronday, M. J., Stilma, J. S., Barbe, R. F., et al. (1994) · British Journal of Ophthalmology · doi:10.1136/bjo.78.9.690 · Cited by 41 · see citing works
[Ocular prognosis in Behçet's disease].
Cochereau, I., Wechsler, B., LeHoang, P., et al. (1992) · PubMed · Cited by 41 · see citing works
The treatment of chronic uveitic macular oedema.
Dick, A. D. (1994) · British Journal of Ophthalmology · doi:10.1136/bjo.78.1.1 · Cited by 39 · see citing works
Role of the Vitreous in the Prognosis of Peripheral Uveitis
Hikichi, T., & Trempe, C. L. (1993) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)71395-9 · Cited by 33 · see citing works
Inflammation in the region of the vitreous base. Pars planitis.
Gh, C., Rk, B., & Cleary, P. E. (1976) · PubMed · Cited by 32 · see citing works
Systemic steroid prophylaxis for cataract surgery in patients with posterior uveitis
Barton, K., Hall, A. J. H., Rosen, P., et al. (1994) · Ocular Immunology and Inflammation · doi:10.3109/09273949409057078 · Cited by 21 · see citing works
Lightman, S. (1991) · The Lancet · doi:10.1016/0140-6736(91)92310-x · Cited by 20 · see citing works
Visual prognosis in Behçet's disease
Towler, H. M. A., & Lightman, S. (1993) · Ocular Immunology and Inflammation · doi:10.3109/09273949309085025 · Cited by 15 · see citing works
Sultan, A. S., & Jessri, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-36797-7_27 · Cited by 13 · see citing works
Ocular manifestations of genetic and developmental diseases
Diamond, G. R. (1994) · Current Opinion in Ophthalmology · doi:10.1097/00055735-199412000-00012 · Cited by 7 · see citing works
Malinowski, S. M., Folk, J. C., & Pulido, J. S. (1994) · Current Opinion in Ophthalmology · doi:10.1097/00055735-199406000-00013 · Cited by 7 · see citing works
Complications of cataract and intraocular lens surgery
Lebuisson, D. A. (1994) · Current Opinion in Ophthalmology · doi:10.1097/00055735-199402000-00011 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Vadot E, Barth E, Billet P. Epidemiology of uveitis -pre- liminary results of a prospective study in Savoy. In: Saari KM, ed. Uveitis update. Amsterdam: Elsevier, 1984: 13-6.
- Bennet PH, Burch TA. New York symposium on popula- tion studies in the rheumatic diseases. New diagnostic criteria. Bull Rheum Dis 1967; 17: 453-8.
- McGavin M. Reaching for high standards of eye care. Community Eye Health 1993; 6: 1-2.
- Loewer-Sieger DH, Rothova A, Koppe JG, Kijlstra A. Congenital toxoplasmosis: a prospective study based on 1821 pregnant women. In: Saari KM, ed. Uveitis update. Amsterdam: Elsevier, 1984: 203-7.
- Wilson CB, Remington JS, Stagno S, Reynold DW. Development ofadverse sequelae in children born with sub- clinical toxoplasma infection. Pediatrics 1980; 66: 767-74.
- Cochereau-Massin I, Wechsler B, Le Hoang P, Le Thi Huong Du, Girard B, Rousselie F, et al. Prognostic ocu- laire de la maladie de Behcet. J Fr Ophtalmol 1992; 15: 343-47.
Cited by
Sorted by citations
The possible impact of uveitis in blindness: a literature survey.
Suttorp-Schulten, M. S., & Rothova, A. (1996) · British Journal of Ophthalmology · doi:10.1136/bjo.80.9.844 · Cited by 616 · see citing works
Self-citationGuidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis
Dick, A. D., Rosenbaum, J. T., Al-Dhibi, H. A., Belfort, R., Brézin, A. P., Chee, S. P., Davis, J. L., Ramanan, A. V., Sonoda, K.-H., Carreño, E., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2017.11.017 · Cited by 285 · see citing works
Self-citationMycophenolate Mofetil Therapy for Inflammatory Eye Disease
Thorne, J. E., Jabs, D. A., Qazi, F. A., Nguyen, Q. D., Kempen, J. H., & Dunn, J. P. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.02.020 · Cited by 219 · see citing works
Efficacy and Safety of Suprachoroidal CLS-TA for Macular Edema Secondary to Noninfectious Uveitis
Yeh, S., Khurana, R. N., Shah, M., Henry, C. R., Wang, R. C., Kissner, J. M., Ciulla, T. A., & Noronha, G. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2020.01.006 · Cited by 191 · see citing works
Clinical Spectrum of HLA-B27-Associated Ocular Inflammation
Pathanapitoon, K., Dodds, E. M., Cunningham, E. T., & Rothova, A. (2017) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2016.1185527 · Cited by 75 · see citing works
Corticosteroid-sparing therapy: practice patterns among uveitis specialists
Esterberg, E., & Acharya, N. R. (2012) · Journal of Ophthalmic Inflammation and Infection · doi:10.1007/s12348-011-0047-5 · Cited by 58 · see citing works
Use of methotrexate in the management of sight-threatening uveitis
Bom, S., Zamiri, P., & Lightman, S. (2001) · Ocular Immunology and Inflammation · doi:10.1076/ocii.9.1.35.3983 · Cited by 55 · see citing works
Copland, D. A., Liu, J., Schewitz-Bowers, L. P., Brinkmann, V., Anderson, K., Nicholson, L. B., & Dick, A. D. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.008 · Cited by 50 · see citing works
Investigation of Cas9 Antibodies in the Human Eye
Toral, M. A., Charlesworth, C. T., Ng, B., Chemudupati, T., Homma, S., Nakauchi, H., Bassuk, A. G., Porteus, M. H., & Mahajan, V. B. (2022) · Nature Communications · doi:10.1038/s41467-022-28674-1 · Cited by 28 · see citing works
Llorenç, V., Nakamura, Y., Metea, C., Karstens, L., Molins, B., & Lin, P. (2022) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.63.3.30 · Cited by 20 · see citing works
Wilson, L., Lewis, K. E., Evans, L. S., Dillon, S. R., & Pepple, K. L. (2023) · Translational Vision Science & Technology · doi:10.1167/tvst.12.3.27 · Cited by 5 · see citing works
- Authors
- Rothova, A., Suttorp-van Schulten, M. S., Frits Treffers, W., & Kijlstra, A.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1996-04-01
- Volume
- 80
- Issue
- 4
- Pages
- 332-336
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC505460
- OpenAlex
- W1979534828
- Cited by
- 904
- References
- 36
- Citations by year
- 2026: 30 · 2025: 36 · 2024: 27 · 2023: 44 · 2022: 47 · 2021: 59 · 2020: 45 · 2019: 48 · 2018: 42 · 2017: 43 · 2016: 56 · 2015: 48 · 2014: 40 · 2013: 36 · 2012: 36
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- uveitis, blindness, visual impairment, cystoid macular edema, panuveitis, ocular toxoplasmosis, juvenile idiopathic arthritis, sarcoidosis, visual prognosis, uveitis complications, surgical treatment
- MeSH terms
- Arthritis, Juvenile, Blindness, Cross-Sectional Studies, Humans, Macular Edema, Netherlands, Retrospective Studies, Risk Factors, Sarcoidosis, Uveitis
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