Corticosteroid-sparing therapy: practice patterns among uveitis specialists
Open accessAbstract
PURPOSE: This study aims to determine uveitis specialists' practice patterns, preferences, and perceptions of corticosteroid-sparing therapies for the initial treatment of chronic noninfectious uveitis. METHODS: A survey was distributed to the American Uveitis Society and Proctor email listservs in order to restrict the respondents to specialists who likely have extensive experience in the use of immunomodulatory therapy. Topics included effectiveness, usage, and preferences related to seven immunomodulatory treatments. RESULTS: Among the 45 responders, the majority (59%) had greater than 10 years of experience treating uveitis. Methotrexate was the most commonly used initial therapy for anterior, intermediate, and posterior/panuveitis (85%, 57%, and 37%), and the most preferred for anterior (55%). Mycophenolate mofetil was the most preferred for intermediate (35%) and posterior/panuveitis (42%). Primary reasons not to prescribe a treatment were effectiveness for azathioprine, safety/tolerability for cyclosporine and cyclophosphamide, and a mixture of cost, safety/tolerability, and difficulty of administration for the biologic drugs. CONCLUSIONS: Within the group of highly experienced uveitis specialists, methotrexate is still the most commonly used initial treatment. Although newer biologic drugs are seen as effective, they are not commonly used, or even preferred, as initial corticosteroid-sparing treatment.
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An earlier survey reported that uveitis specialists chose mycophenolate mofetil over other immunosuppressants for initial corticosteroid-sparing therapy in intermediate, posterior, and pan-uveitis.
“This is in line with results from a previous survey where uveitis specialists preferred mycophenolate mofetil over other immunosuppressive agents as an initial corticosteroid-sparing treatment for intermediate, posterior, and pan-uveitis.22”
From A Bayesian Analysis of a Randomized Clinical Trial Comparing Antimetabolite Therapies for Non-Infectious Uveitis (2017) · cites this paper as [22]
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- Authors
- Esterberg, E., & Acharya, N. R.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Acharya, Nisha R.
- Venue
- Journal of Ophthalmic Inflammation and Infection
- Published
- 2011-11-06
- Volume
- 2
- Issue
- 1
- Pages
- 21-28
- ISSN
- 1869-5760 (ISSN-L)
- PMC
- PMC3302992
- OpenAlex
- W2122840113
- Cited by
- 58
- References
- 31
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 3
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Ophthalmic Inflammation and Infection (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Research to Prevent Blindness (EY02162)
- National Eye Institute (EY02162, P30EY002162, K23EY017897)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Keywords
- steroid-sparing therapy, immunomodulatory therapy, clinical practice patterns, methotrexate, mycophenolate mofetil, azathioprine, cyclosporine, cyclophosphamide, biologic drugs, treatment preferences
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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