The effect of glucosamine supplementation on people experiencing regular knee pain
Open accessAbstract
Objective:The purpose of this study was to examine the effects of oral glucosamine supplementation on the functional ability and degree of pain felt by individuals who had regular knee pain, most likely due to previous articular cartilage damage, and possibly osteoarthritis. Methods:Subjects were randomly supplemented with either glucosamine (G) (n=24) or placebo (P) (lactose) (n=22) for 12 weeks at a dose of 2000 mg per day. Over this period, four testing sessions were conducted, with changes in knee pain and function assessed by clinical and functional tests, (joint line palpation, a 3 metre “duck walk” and a repeated, walking stair climb), two questionnaires (the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Knee Pain Scale (KPS)) and participant subjective evaluations. Results:The clinical and functional test scores improved with time (main effects: p<0.05, p<0.01) but there were no significant differences between the two groups. The questionnaire results also recorded a significant main effect for time (p<0.05), but the glucosamine group was found to have significantly better KOOS quality of life scores at week eight and 12 (p<0.05), and lower KPS scores (p<0.05) at week eight than the placebo group. On self report evaluations of changes across the 12 week supplementation period, 88% (n=21) of the glucosamine group reported some degree of improvement in their knee pain versus only 17% (n=3) in the placebo group. Conclusions:These results suggest that glucosamine supplementation can provide some degree of pain relief and improved function in persons who experience regular knee pain, which may be caused by prior cartilage injury and/or osteoarthritis. The trends in the results also suggest that, at a dosage of 2000 mg per day, the majority of improvements are present after eight weeks.
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Glucosamine and chondroitin have been reported to slow cartilage degeneration and reduce the degree of joint pain in active individuals which may help athletes postpone and/or prevent joint problems.
“Glucosamine and chondroitin have been reported to slow cartilage degeneration and reduce the degree of joint pain in active individuals which may help athletes postpone and/or prevent joint problems [692, 693].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [692]
The Abstract reports that glucosamine supplementation provided some pain relief in people with regular knee pain and describes limiting cartilage degeneration as a potential benefit. The Discussion says effects on cartilage integrity await further research. The paper does not establish that chondroitin has these effects or that either supplement prevents joint problems in athletes. (LLM, conf=0.88)
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Cites
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ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
ISSN exercise & sport nutrition review: research & recommendations
Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428 · see citing works
ISSN Exercise & Sport Nutrition Review: Research & Recommendations
Kreider, R. B., Almada, A. L., Antonio, J., Broeder, C., Earnest, C., Greenwood, M., Incledon, T., Kalman, D. S., Kleiner, S. M., Leutholtz, B., et al. (2004) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-1-1-1 · Cited by 38 · see citing works
- Authors
- Braham, R., Dawson, B., & Goodman, C.
- Affiliations
- The University of Western Australia (AU)
- Corresponding author
- Braham, R
- ORCID
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 2003-02
- Volume
- 37
- Issue
- 1
- Pages
- 45-49
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- PMC
- PMC1724589
- OpenAlex
- W2132274011
- Cited by
- 89
- References
- 20
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 11 · 2019: 1 · 2018: 3 · 2017: 2 · 2015: 3 · 2014: 8 · 2013: 4
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Sports Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
- Keywords
- glucosamine, knee pain, osteoarthritis, articular cartilage damage, knee function, analgesia, dietary supplementation, KOOS, placebo comparison
- MeSH terms
- Administration, Oral, Adult, Aged, Analysis of Variance, Chronic Disease, Exercise Test, Female, Glucosamine, Humans, Knee Joint, Male, Middle Aged, Pain Measurement, Arthralgia
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