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Cited by 106Hormonal and reproductive studiesSports Performance and TrainingAdrenal Hormones and Disorders

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Effects of moderately increased testosterone concentration on physical performance in young women: a double blind, randomised, placebo controlled study

Hirschberg, Angelica Lindén, Elings Knutsson, Jona, Helge, Torbjörn, Godhe, Manne, Ekblom, Maria, Bermon, Stephane, Ekblom, Björn·2020·British Journal of Sports Medicine
DOI 10.1136/bjsports-2018-100525
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Abstract

Objective: To investigate the effects of a moderate increase in serum testosterone on physical performance in young, physically active, healthy women. Methods: A double blind, randomised, placebo controlled trial was conducted between May 2017 and June 2018 (ClinicalTrials.gov ID: NCT03210558). 48 healthy, physically active women aged 18–35 years were randomised to 10 weeks of treatment with 10 mg of testosterone cream daily or placebo (1:1). All participants completed the study. The primary outcome measure was aerobic performance measured by running time to exhaustion (TTE). Secondary outcomes were anaerobic performance (Wingate test) and muscle strength (squat jump (SJ), counter movement jump (CMJ) and knee extension peak torque). Hormone levels were analysed and body composition assessed by dual energy X-ray absorptiometry. Results: Serum levels of testosterone increased from 0.9 (0.4) nmol/L to 4.3 (2.8) nmol/L in the testosterone supplemented group. TTE increased significantly by 21.17 s (8.5%) in the testosterone group compared with the placebo group (mean difference 15.5 s; P=0.045). Wingate average power, which increased by 15.2 W in the testosterone group compared with 3.2 W in the placebo group, was not significantly different between the groups (P=0.084). There were no significant changes in CMJ, SJ and knee extension. Mean change from baseline in total lean mass was 923 g for the testosterone group and 135 g for the placebo group (P=0.040). Mean change in lean mass in the lower limbs was 398 g and 91 g, respectively (P=0.041). Conclusion: The study supports a causal effect of testosterone in the increase in aerobic running time as well as lean mass in young, physically active women.

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  1. Bar-Or, 1977, 30-sec all-out ergometric test-its reliability and validity for anaerobic capacity, Isr J Med Sci, 13, 326

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Metadata

Authors
Hirschberg, A. L., Elings Knutsson, J., Helge, T., Godhe, M., Ekblom, M., Bermon, S., & Ekblom, B.
Affiliations
  • Karolinska University Hospital (SE)
  • Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
  • Swedish School of Sport and Health Sciences (SE)
  • Monaco Institute of Sports Medicine, Monaco
  • Astrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden
Corresponding author
Hirschberg, Angelica Lindén
ORCID
Venue
British Journal of Sports Medicine
Publisher
BMJ
Published
2019-10-15
Volume
54
Issue
10
Pages
599-604
ISSN
  • 0306-3674 (ISSN-L)
  • 1473-0480
DOI
10.1136/bjsports-2018-100525
OpenAlex
W2981269334
Cited by
106
References
31
Citations by year
2026: 13 · 2025: 16 · 2024: 12 · 2023: 24 · 2022: 12 · 2021: 15 · 2020: 13 · 2019: 1
FWCI
8.32
Type
journal article
Language
en
Open access
closed
Locations
  • British Journal of Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Karolinska Institutet
  • Swedish Military Forceś Research Authorities (#AF9220914)
  • International Athletics Foundation
  • Swedish Research Council for Sport Science
  • Swedish Research Council (2017-02051)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone supplementation, serum testosterone, physical performance, young women, aerobic performance, time to exhaustion, anaerobic performance, muscle strength, lean body mass, body composition, physically active women
MeSH terms
Adolescent, Adult, Body Composition, Double-Blind Method, Exercise Test, Female, Humans, Running, Sex Characteristics, Testosterone, Body Mass Index, Muscle Strength, Athletic Performance, Young Adult, Performance-Enhancing Substances

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