Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women

Horwath, Oscar; Apró, William; Moberg, Marcus; Godhe, Manne; Helge, Torbjörn; Ekblom, Maria; Hirschberg, Angelica Lindén; Ekblom, Björn

doi:10.1152/japplphysiol.00893.2019

Cited by 70Hormonal and reproductive studiesSports Performance and TrainingMuscle Physiology and Disorders

Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women

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Horwath, Oscar, Apró, William, Moberg, Marcus, Godhe, Manne, Helge, Torbjörn, Ekblom, Maria, Hirschberg, Angelica Lindén, Ekblom, Björn·2020·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00893.2019

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Abstract

We have recently demonstrated performance-enhancing effects of moderately elevated testosterone concentrations in young women. Here we present novel evidence that testosterone alters muscle morphology in these women, resulting in type II fiber hypertrophy and improved capillarization. Our findings suggest that low doses of testosterone potently impact skeletal muscle after only 10 wk. These data provide unique insights into muscle adaptation and support the performance-enhancing role of testosterone in women on the muscle fiber level.

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Horwath et al. showed no change in myonuclei content following a 10-week testosterone administration of 10 mg daily protocol, coupled with a 31% increase in satellite cells associated with type II fibres in the testosterone group.
“Horwath et al. showed no change in the myonuclei content following a 10-week testosterone administration of 10 mg daily protocol [83] coupled with an interesting finding of a 31% increase in satellite cells associated with type II fibres in the testosterone group.”
From Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement (2021) · cites this paper as [83]
The 'peak pegging' hypothesis found in female mice does not transfer to young healthy, physically active women.
“However, this “peak pegging” hypothesis found in female mice does not transfer to young healthy, physically active women.”
From Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement (2021) · cites this paper as [83]
The Discussion (pp. 18, 23) reports that testosterone caused type II muscle-fiber hypertrophy in young, physically active women. Our copy does not describe a “peak pegging” hypothesis in female mice or test whether that hypothesis transfers to women (searched: peak pegging, female mice). (LLM, conf=0.72)
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Authors: Horwath, O., Apró, W., Moberg, M., Godhe, M., Helge, T., Ekblom, M., Hirschberg, A. L., & Ekblom, B.
Affiliations: Swedish School of Sport and Health Sciences (SE)
Karolinska University Hospital (SE)
Åstrand Laboratory, Swedish School of Sport and Health Sciences, Stockholm, Sweden
Corresponding author: Horwath, Oscar
ORCID: Horwath, Oscar
Apró, William
Moberg, Marcus
Godhe, Manne
Ekblom, Maria
Hirschberg, Angelica Lindén
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2020-05-01
Volume: 128
Issue: 5
Pages: 1240-1250
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00893.2019
OpenAlex: W3011240533
Cited by: 70
References: 66
Citations by year: 2026: 7 · 2025: 17 · 2024: 6 · 2023: 11 · 2022: 21 · 2021: 6 · 2020: 2
FWCI: 7.54
Type: journal article
Language: en
Open access: green
urn.kb.se
Licence: other-oa
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders: The Swedish Research Council (2017-02051)
The Swedish Research Council for Sport Science (P2018-0197, P2019-0098, D2019-0050, D2017-0012)
The Swedish Military Research Authority (#AF 922 0916)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: testosterone, skeletal muscle, muscle fiber type, capillarization, muscle morphology, muscle adaptation, performance improvement, young women, sex differences
MeSH terms: Female, Humans, Hypertrophy, Male, Testosterone, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Resistance Training

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Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women

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