Trial of ascorbic acid in prevention of colds
Open accessAbstract
Sera from 20 patients with chronic bronchitis have been examined for viral complement-fixing antibodies over a period of four years.During this time 68 exacerbations occurred, but only 3 (4.4°/%) of them could be related to viral infection.Elevated antibody titres were found to persist over a long period of time and the significance of this finding is discussed.We would particularly acknowledge the co-operation of the patients involved in this study.We would also thank the clinicians:
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Doses of 3 g/day vitamin C have not prevented natural colds in ordinary people (Karlowski 1975) or laboratory colds (Walker 1967; Schwartz 1973).
“Doses of 3 g/day vitamin C have not prevented natural colds in ordinary people (Karlowski 1975) or laboratory colds (Walker 1967; Schwartz 1973).”
From Vitamin C for preventing and treating the common cold (2013) · cites this paper as Walker 1967
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Cites
Common Colds and related Diseases
Tyrrell, D. A. J. (1966) · Public Health · doi:10.1016/s0033-3506(66)80038-0 · Cited by 73 · see citing works
Self-citationLYSOSOMAL ENZYMES IN CELLS INFECTED WITH CYTOPATHIC AND NON-CYTOPATHIC VIRUSES
Mallucci, L., & Allison, A. C. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.121.3.477 · Cited by 59 · see citing works
(1961) · PubMed · Cited by 49 · see citing works
USEFULNESS OF BIOFLAVONOIDS AND ASCORBIC ACID IN TREATMENT OF COMMON COLD
Tebrock, H. E. (1956) · JAMA · doi:10.1001/jama.1956.02970300027010 · Cited by 28 · see citing works
Citrus bioflavonoids in the treatment of the common cold.
Macon, W. L. (1956) · PubMed · Cited by 6 · see citing works
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Research works printed but not linked: 3
- Ross, C. A. C., McMichael, S., Eadie, M. B., Lees, A. W., Murray, B. A., and Pinkerton, I. (1967). Thorax. In press.
- Tyrrell, D. A. J., and Bynoe, M. L. (1966). Lancet, 1, 76. Trial of Ascorbic Acid in Prevention of Colds GEORGINA H. WALKER,* M.B., CH.B.; M. L. BYNOE,* M.B., D.T.M.&H.; D. A. J. TYRRELL,* M.D., F.R.C.P. Brit. med. J., 1967, 1, 603-606 REFERENCES
- Almeida, J., and Tyrrell, D. A. J. (1967). 7. gen. Virol. In press.
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Vitamin C for preventing and treating the common cold
Hemilä, H., & Chalker, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000980.pub4 · Cited by 869 · see citing works
Effects of ascorbic acid on the common cold
Chalmers, T. C. (1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90127-8 · Cited by 155 · see citing works
Kleijnen, J., & Knipschild, P. (1992) · Pharmaceutisch Weekblad Scientific Edition · doi:10.1007/bf01977620 · Cited by 89 · see citing works
Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man
Schwartz, A. R., Togo, Y., Hornick, R. B., Tominaga, S., & Gleckman, R. A. (1973) · Journal of Infectious Diseases · doi:10.1093/infdis/128.4.500 · Cited by 74 · see citing works
- Authors
- Walker, G. H., Bynoe, M. L., & Tyrrell, D. A.
- ORCID
- Walker, G. H.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1967-03-11
- Volume
- 1
- Issue
- 5540
- Pages
- 603-606
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1841434
- OpenAlex
- W2031385610
- Cited by
- 84
- References
- 5
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- vitamin C, common cold, cold prevention, chronic bronchitis, complement-fixing antibodies, viral infection, antibody persistence
- MeSH terms
- Adenoviridae, Adolescent, Adult, Animals, Ascorbic Acid, Common Cold, Enterovirus, Female, Humans, Male, Middle Aged, Orthomyxoviridae, Respiratory Syncytial Viruses, Rhinovirus, Poliovirus, Respirovirus, Simplexvirus, Enterovirus B, Human, Culture Techniques, Mice
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