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Controlled Sedation with Alphaxalone-Alphadolone
Open accessAbstract
Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided “light sleep,” allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system. Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.
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Cited by
Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695
Drakulovic, M. B., Torres, A., Bauer, T. T., Nicolas, J. M., Nogué, S., & Ferrer, M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12251-1 · Cited by 1,243
Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients
Riker, R. R., Picard, J. T., & Fraser, G. L. (1999) · Critical Care Medicine · doi:10.1097/00003246-199907000-00022 · Cited by 961
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome
The National Heart, L. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1901686 · Cited by 886
Neurosteroids and GABAA receptor function
Lambert, J. J., Belelli, D., Hill-Venning, C., & Peters, J. A. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89058-6 · Cited by 746
Metadata
- Authors
- Ramsay, M. A. E., Savege, T. M., Simpson, B. R. J., & Goodwin, R.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1974-06-22
- Volume
- 2
- Issue
- 5920
- Pages
- 656-659
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W1973798824
- Cited by
- 2,861
- References
- 0
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ramsay, M. A. E., Savege, T. M., Simpson, B. R. J., & Goodwin, R. (1974). Controlled Sedation with Alphaxalone-Alphadolone. BMJ. https://doi.org/10.1136/bmj.2.5920.656
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
