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Controlled Sedation with Alphaxalone-Alphadolone
Open accessAbstract
Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided “light sleep,” allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system. Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.
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Metadata
- Authors
- Ramsay, M. A. E., Savege, T. M., Simpson, B. R. J., & Goodwin, R.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1974-06-22
- Volume
- 2
- Issue
- 5920
- Pages
- 656-659
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W1973798824
- Cited by
- 2,861
- References
- 0
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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