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Down's syndrome: an atheroma-free model?
Abstract
Postmortem examination of five institutionalised patients with Down's syndrome (DS) aged 40-66 years showed a complete absence of atheroma, while a similar number of mental defectives with DS were found to have mild or severe atheroma. Previous investigation of risk factors for atheroma in 70 patients with DS and 70 age-and sex-matched mental defectives living in the same institution showed significantly lower systolic and diastolic blood pressures in the DS group, with the exception of systolic pressure in men under 40. Fasting serum cholesterol and triglyceride concentrations were similar in the two groups, but triglyceride concentrations were significantly lower than in normal people without a history of vascular disease. These unexplained observations may be relevant in further studies of the pathogenesis of atheroma.
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The serum cholesterol and lipid profiles of individuals with trisomy 21 are abnormal, yet they are protected against atherosclerosis.
“Interestingly, the serum cholesterol and lipid profiles of these individuals are abnormal, yet they are protected against atherosclerosis [55], [56].”
From LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease (2010) · cites this paper as [55]
The Abstract reports no atheroma in five patients with Down’s syndrome and significantly lower triglycerides than in people living at home. It also says cholesterol and triglyceride concentrations were similar to those of the institutional control group. The claim overstates the evidence by describing cholesterol profiles generally as abnormal and protection against atherosclerosis as established for all individuals with trisomy 21. (LLM, conf=0.84)
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Research works printed but not linked: 3
- Murdoch, J C, et al, J'ournal of Clinical Endocrinology, 1977, 44, 453.
- 3Blackburn, H, et al, Circulation, 1960, 21, 1160.
- 4Annan, R, and Isherwood, E M,J7ournal of Medical Laboratory Technology, 1969, 26, 202.
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Cerebrovascular pathology in Down syndrome and Alzheimer disease
Head, E., Phelan, M. J., Doran, E., Kim, R. C., Poon, W. W., Schmitt, F. A., & Lott, I. T. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0499-4 · Cited by 105
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Wilcock, D. M., Schmitt, F. A., & Head, E. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.007 · Cited by 56
Abisambra, J. F., Fiorelli, T., Padmanabhan, J., Neame, P., Wefes, I., & Potter, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008556 · Cited by 42
Metadata
- Authors
- Murdoch, J. C., Rodger, J. C., Rao, S. S., Fletcher, C. D., & Dunnigan, M. G.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1977-07-23
- Volume
- 2
- Issue
- 6081
- Pages
- 226-228
- ISSN
- 0007-1447
- 1468-5833
- Cited by
- 179
- References
- 0
- Language
- en
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