Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Wilcock, Donna M.; Schmitt, Frederick A.; Head, Elizabeth

doi:10.1016/j.bbadis.2015.11.007

Cited by 56Down syndrome and intellectual disability researchDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

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Wilcock, Donna M., Schmitt, Frederick A., Head, Elizabeth·2016·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2015.11.007PMC PMC4821721

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Abstract

Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

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Increased APP gene dosage is associated with CAA and Down syndrome-AD.
“For example, increased APP gene dosage is associated with CAA and Down syndrome-AD [609].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [609]

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Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,604 · see citing works
Cerebrovascular "Moyamoya" Disease
Suzuki, J. (1969) · Archives of Neurology · doi:10.1001/archneur.1969.00480090076012 · Cited by 2,189 · see citing works
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Cerebrovascular "Moyamoya" Disease
Suzuki, J., & Kodama, N. (1971) · Angiology · doi:10.1177/000331977102200408 · Cited by 1,635 · see citing works
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137 · see citing works
Cerebral amyloid angiopathy. A critical review.
Vinters, H. V. (1987) · Stroke · doi:10.1161/01.str.18.2.311 · Cited by 1,070 · see citing works
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
Attems, J., & Jellinger, K. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0206-2 · Cited by 739 · cited 1× · see citing works
“As mentioned previously, the CVD contribution to AD is increasingly being recognized as a critical comorbidity that accelerates the age of onset of dementia and also leads to a faster progression of the disease [2,5,28,41].”
Background
Cerebral Amyloid Angiopathy
Weller, R. O., Massey, A., Newman, T. A., Hutchings, M., Kuo, Y.-M., & Roher, A. E. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65616-7 · Cited by 679 · see citing works
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works
Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation
Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584 · cited 2× · see citing works
“However, several interesting studies show significant diffuse plaque accumulation in much younger individuals such as the work by Lemere and colleagues and Leverenz and Raskind [51,53].”
Background
A Prospective Study of Alzheimer Disease in Down Syndrome
Lai, F., & Williams, R. S. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520440031017 · Cited by 561 · see citing works
The four ages of Down syndrome.
Bittles, A., Bower, C., Hussain, R., & Glasson, E. (2007) · European Journal of Public Health · doi:10.1093/eurpub/ckl103 · Cited by 505 · see citing works
The changing survival profile of people with Down's syndrome: implications for genetic counselling
Glasson, E. J., Sullivan, S. G., Hussain, R., Petterson, B. A., Montgomery, P. D., & Bittles, A. H. (2002) · Clinical Genetics · doi:10.1034/j.1399-0004.2002.620506.x · Cited by 477 · see citing works
The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
Molecular mapping of alzheimer‐type dementia in Down's syndrome
Prasher, V. P., Farrer, M. J., Kessling, A. M., Fisher, E. M. C., West, R. J., Barber, P. C., & Butler, A. C. (1998) · Annals of Neurology · doi:10.1002/ana.410430316 · Cited by 414 · see citing works
Mixed Dementia
Langa, K. M., Foster, N. L., & Larson, E. B. (2004) · JAMA · doi:10.1001/jama.292.23.2901 · Cited by 392 · see citing works
Obesity and obesity‐related secondary conditions in adolescents with intellectual/developmental disabilities
Rimmer, J. H., Yamaki, K., Lowry, B. M. D., Wang, E., & Vogel, L. C. (2010) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2010.01305.x · Cited by 354 · see citing works
Pathology and pathogenesis of vascular cognitive impairment—a critical update
Jellinger, K. A. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00017 · Cited by 353 · cited 1× · see citing works
“7 to 45% in autopsy cases from the general population [43].”
Background
Classification of human chromosome 21 gene-expression variations in down syndrome: impact on disease phenotypes
Aït Yahya-Graison, E., Aubert, J., Dauphinot, L., Rivals, I., Prieur, M., Golfier, G., Rossier, J., Personnaz, L., Créau, N., Bléhaut, H., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/520000 · Cited by 338 · see citing works
Obstructive Sleep Apnea
Shott, S. R., Amin, R. S., Chini, B. A., Heubi, C. H., Hotze, S. L., & Akers, R. (2006) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.132.4.432 · Cited by 295 · see citing works
Atypical aging in down syndrome
Zigman, W. B. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1128 · Cited by 262 · see citing works
Experimental models of vascular dementia and vascular cognitive impairment: a systematic review
Jiwa, N. S., Garrard, P., & Hainsworth, A. H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06958.x · Cited by 257 · see citing works
Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
Pogribna, M., Melnyk, S., Pogribny, I. P., Chango, A., Yi, P., & James, S. J. (2001) · The American Journal of Human Genetics · doi:10.1086/321262 · Cited by 241 · see citing works
Growth charts for Down's syndrome from birth to 18 years of age
Myrelid, Å. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.87.2.97 · Cited by 237 · see citing works
Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
Wilcock, D. M., & Griffin, W. S. T. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-84 · Cited by 230 · see citing works
Self-citation
Down's syndrome: an atheroma-free model?
Murdoch, J. C., Rodger, J. C., Rao, S. S., Fletcher, C., & Dunnigan, M. G. (1977) · BMJ · doi:10.1136/bmj.2.6081.226 · Cited by 221 · see citing works
Early Amyloid Deposition in the Medial Temporal Lobe of Young Down Syndrome Patients: A Regional Quantitative Analysis
Leverenz, J. B., & Raskind, M. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6777 · Cited by 214 · see citing works
Obesity in adults with Down syndrome: a case–control study
Melville, C. A., Cooper, S., McGrother, C. W., Thorp, C. F., & Collacott, R. A. (2004) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2004.00616.x · Cited by 209 · see citing works
Associations Between Sleep Architecture and Sleep‐Disordered Breathing and Cognition in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study
BLACKWELL, T. L., Yaffe, K. S., Ancoli‐Israel, S., Redline, S. S., Ensrud, K. E., Stefanick, M. L., Laffan, A. M., Stone, K. L., & for the Osteoporotic Fractures in Men Study Group (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03731.x · Cited by 207 · see citing works
Dementia From Alzheimer Disease and Mixed Pathologies in the Oldest Old
James, B. D. (2012) · JAMA · doi:10.1001/jama.2012.3556 · Cited by 199 · see citing works
Cerebrovascular Consequences of Obstructive Sleep Apnea
Durgan, D. J., & Bryan, R. M. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.111.000091 · Cited by 195 · see citing works
Neuroinflammatory phenotype in early Alzheimer's disease
Sudduth, T. L., Schmitt, F. A., Nelson, P. T., & Wilcock, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.012 · Cited by 194 · see citing works
Self-citation
Obstructive Sleep Apnea as a Risk Factor for Cerebral White Matter Change in a Middle-Aged and Older General Population
Kim, H., Yun, C., THOMAS, R. J., Lee, S. H., Seo, H. S., Cho, E. R., Lee, S. K., Yoon, D. W., Suh, S. A., & Shin, C. (2013) · SLEEP · doi:10.5665/sleep.2632 · Cited by 193 · see citing works
White Matter Hyperintensities and Cerebral Amyloidosis: Necessary and Sufficient for Clinical Expression of Alzheimer Disease?
Provenzano, F. A., Muraskin, J., Tosto, G., Narkhede, A., Wasserman, B. T., Griffith, E. Y., Guzman, V. A., Meier, I. B., Zimmerman, M. E., Brickman, A. M., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1321 · Cited by 192 · see citing works
Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain
Farkas, E., Donka, G., de Vos, R. A. I., Mihály, A., Bari, F., & Luiten, P. G. M. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0864-9 · Cited by 190 · see citing works
Genetic and host factors for dementia in Down's syndrome
Schupf, N. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.5.405 · Cited by 188 · see citing works
Temporal Accrual of Complement Proteins in Amyloid Plaques in Down's Syndrome with Alzheimer's Disease
Stoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., & Lemere, C. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64753-0 · Cited by 187 · see citing works
Changes in mortality and causes of death in the Swedish Down syndrome population
Englund, A., Jönsson, B., Zander, C. S., Gustafsson, J., & Annerén, G. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35706 · Cited by 184 · see citing works
Down syndrome: a cardiovascular perspective
Vis, J. C., Duffels, M. G. J., Winter, M. M., Weijerman, M. E., Cobben, J. M., Huisman, S. A., & Mulder, B. J. M. (2009) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2009.01158.x · Cited by 180 · see citing works
Health Conditions Associated with Aging and End of Life of Adults with Down Syndrome
Esbensen, A. J. (2010) · International review of research in mental retardation · doi:10.1016/s0074-7750(10)39004-5 · Cited by 176 · see citing works
Obstructive Sleep Apnea in Adults with Down Syndrome
Trois, M. S., Capone, G. T., Lutz, J., Melendres, M. C., Schwartz, A. R., Collop, N. A., & Marcus, C. L. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27541 · Cited by 176 · see citing works
Study of Down syndrome in 238,942 consecutive births.
Stoll, C. G., Alembik, Y., Dott, B., & Roth, M. (1998) · PubMed · Cited by 161 · see citing works
Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Jones, S. F. (2012) · Yearbook of Pulmonary Disease · doi:10.1016/j.ypdi.2012.01.058 · Cited by 159 · see citing works
Precocious aging and dementia in patients with Down's syndrome.
Wisniewski, K. E., Howe, J., Williams, D. G., & Wisniewski, H. M. (1978) · PubMed · Cited by 153 · see citing works
Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer’s disease and vascular dementia
Akinyemi, R., Mukaetova-Ladinska, E., Attems, J., Ihara, M., & Kalaria, R. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990037 · Cited by 152 · see citing works
Fallacies in the pathological confirmation of the diagnosis of Alzheimer’s disease
Bowler, J., Muñoz, D., Merskey, H., & Hachinski, V. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.18 · Cited by 148 · see citing works
Alzheimer's Disease in Down Syndrome.
Head, E., Powell, D. K., Gold, B. T., & Schmitt, F. A. (2012) · PubMed · Cited by 139 · see citing works
Self-citation
Morbidity and medication in a large population of individuals with Down syndrome compared to the general population
Alexander, M., Petri, H., Ding, Y., Wandel, C., Khwaja, O., & Foskett, N. (2015) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12868 · Cited by 138 · see citing works
Life-long overexpression of S100β in Down’s syndrome: implications for Alzheimer pathogenesis
Griffin, W. S. T., Sheng, J. G., McKenzie, J. E., Royston, M. C., Gentleman, S., Brumback, R. A., Cork, L. C., Bigio, M. R. D., Roberts, G. W., & Mrak, R. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00074-8 · Cited by 134 · see citing works
Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models
Frost, J. L., Le, K. X., Cynis, H., Ekpo, E., Kleinschmidt, M., Palmour, R. M., Ervin, F. R., Snigdha, S., Cotman, C. W., Saido, T. C., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.005 · Cited by 132 · see citing works
New cross sectional stature, weight, and head circumference references for Down's syndrome in the UK and Republic of Ireland
Styles, M. E. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.87.2.104 · Cited by 131 · see citing works
Vascular Cognitive Impairment: Disease Mechanisms and Therapeutic Implications
Levine, D. A., & Langa, K. M. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0047-z · Cited by 130 · see citing works
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome
Cenini, G., Dowling, A. L. S., Beckett, T. L., Barone, E., Mancuso, C., Murphy, M. P., LeVine, H., Lott, I. T., Schmitt, F. A., Butterfield, D. A., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.001 · Cited by 122 · see citing works
Self-citation
Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease
Wilcock, D. M., Hurban, J., Helman, A. M., Sudduth, T. L., McCarty, K. L., Beckett, T. L., Ferrell, J. C., Murphy, M. P., Abner, E. L., Schmitt, F. A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.016 · Cited by 110 · see citing works
Self-citation
Down's syndrome and atherosclerosis
Ylä‐Herttuala, S., Luoma, J. S., Nikkari, T., & Kivimäki, T. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90110-x · Cited by 110 · see citing works
White matter lesions defined by diffusion tensor imaging in older adults
Back, S. A., Kroenke, C. D., Sherman, L. S., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B., & Montine, T. J. (2011) · Annals of Neurology · doi:10.1002/ana.22484 · Cited by 109 · see citing works
Trisomy 21 and the Brain
Mrak, R. E., & Griffin, W. S. T. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.679 · Cited by 108 · see citing works
Dementia and mild cognitive impairment in adults with intellectual disability: Issues of diagnosis
Krinsky‐McHale, S. J., & Silverman, W. P. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1126 · Cited by 108 · see citing works
Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease
Wilcock, D. M. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/170276 · Cited by 104 · see citing works
Self-citation
Alzheimer's Disease in the Down Syndrome: An Overview of Genetics and Molecular Aspects
Gomes, F. D. C., Mattos, M. F., Goloni‐Bertollo, E. M., & Pavarino, É. C. (2021) · Neurology India · doi:10.4103/0028-3886.310062 · Cited by 102 · see citing works
Moyamoya and Down Syndrome
Cramer, S. C., Robertson, R. L., Dooling, E. C., et al. (1996) · Stroke · doi:10.1161/01.str.27.11.2131 · Cited by 96 · see citing works
Aging and Down Syndrome
Head, E., Silverman, W. P., Patterson, D. W., & Lott, I. T. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/412536 · Cited by 94 · see citing works
Self-citation
Prevalence of Overweight in Dutch Children With Down Syndrome
van Gameren-Oosterom, H. B. M., van Dommelen, P., Schönbeck, Y., et al. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0886 · Cited by 88 · see citing works
Immediate causes of death of demented and non-demented elderly
Kammoun, S., Gold, G., Bouras, C., Giannakopoulos, P., McGee, W., Herrmann, F. R., & Michel, J.-P. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.00314.x · Cited by 83 · see citing works
Associations between White Matter Hyperintensities and β Amyloid on Integrity of Projection, Association, and Limbic Fiber Tracts Measured with Diffusion Tensor MRI
Chao, L. L., DeCarli, C. S., Kriger, S., Truran, D., Zhang, Y., Laxamana, J., Villeneuve, S., Jagust, W. J., Sanossian, N., Mack, W. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065175 · Cited by 83 · see citing works
Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome
Schupf, N., Zigman, W. B., Tang, M. X., Pang, D. I., Mayeux, R. P., Mehta, P. D., & Silverman, W. P. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fb448b · Cited by 78 · see citing works
Prevalence and Characteristics of Concurrent Down Syndrome in Patients With Moyamoya Disease
Kainth, D. S., Chaudhry, S., Kainth, H., et al. (2012) · Neurosurgery · doi:10.1227/neu.0b013e31827b9beb · Cited by 75 · see citing works
Leptin Levels among Prepubertal Children with Down Syndrome Compared with Their Siblings
Magge, S. N., O’Neill, K. L., Shults, J., et al. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.08.008 · Cited by 74 · see citing works
Cerebral microbleeds are related to loss of white matter structural integrity
Akoudad, S., de Groot, M., Koudstaal, P. J., van der Lugt, A., Niessen, W. J., Albert Hofman, D., Ikram, M. A., & Vernooij, M. W. (2013) · Neurology · doi:10.1212/01.wnl.0000436609.20587.65 · Cited by 73 · see citing works
Comparison of Intima-Media Thickness of the Carotid Artery and Cardiovascular Disease Risk Factors in Adults With Versus Without the Down Syndrome
Draheim, C. C., Geijer, J. R., & Dengel, D. R. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.06.079 · Cited by 71 · see citing works
Low Blood Pressure in Down's Syndrome
Rd, M., McGrath, A., Davidson, G., Brown, J. J., Murray, G. D., & Lever, A. F. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.569 · Cited by 68 · see citing works
Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers A in APP/PS1 Mice Along a Different Time Course than Anti-A Antibodies
Sudduth, T. L., Greenstein, A. W., & Wilcock, D. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1220-13.2013 · Cited by 67 · see citing works
Self-citation
OVERWEIGHT AMONG CHILDREN WITH TRISOMY 21
Chumlea, W. C., & Cronk, C. E. (1981) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1981.tb00118.x · Cited by 60 · see citing works
Diverse Inflammatory Responses in Transgenic Mouse Models of Alzheimer’s Disease and the Effect of Immunotherapy on These Responses
Wilcock, D. M., Zhao, Q., Morgan, D., Gordon, M. N., Everhart, A. L., Wilson, J. G., Lee, J. E., & Colton, C. A. (2011) · ASN NEURO · doi:10.1042/an20110018 · Cited by 58 · see citing works
Self-citation
Obstructive sleep apnea as a risk factor for silent cerebral infarction
Cho, E. R., Kim, H., Seo, H. S., Suh, S. A., Lee, S. K., & Shin, C. (2013) · Journal of Sleep Research · doi:10.1111/jsr.12034 · Cited by 57 · see citing works
Cerebral Amyloid Angiopathy, Subcortical White Matter Disease and Dementia: Literature Review and Study in OPTIMA
Esiri, M. M., Chance, S. A., Joachim, C. L., Warden, D. R., Smallwood, A., Sloan, C., Christie, S., Wilcock, G. K., & Smith, A. D. (2014) · Brain Pathology · doi:10.1111/bpa.12221 · Cited by 55 · see citing works
β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
Sudduth, T. L., Weekman, E. M., Brothers, H. M., Braun, K. J., & Wilcock, D. M. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt262 · Cited by 55 · see citing works
Self-citation
Autoimmunity in Down’s Syndrome: Another Possible Mechanism of Moyamoya Disease
Leno, C., Mateo, I., Cid, C. M., et al. (1998) · Stroke · doi:10.1161/01.str.29.4.868 · Cited by 52 · see citing works
Stiffness of the large arteries in individuals with and without Down syndrome
Rodrigues, A., Coelho, Gonçalves, W. L. S., Gouvêa, Vasconcellos, Cunha, & Abreu (2011) · Vascular Health and Risk Management · doi:10.2147/vhrm.s21273 · Cited by 49 · see citing works
Revisiting Down syndrome from the ENT perspective: review of literature and recommendations
Ramia, M. S., Musharrafieh, U. M., Khaddage, W., et al. (2013) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-013-2563-4 · Cited by 47 · see citing works
Acute Hemiplegia and Cortical Blindness Due to Moya Moya Disease: Report of a Case in a Child With Down's Syndrome
Schrager, G. O., Cohen, S. J., & Vigman, M. P. (1977) · PEDIATRICS · doi:10.1542/peds.60.1.33 · Cited by 46 · see citing works
Moyamoya and other causes of stroke in patients with Down syndrome
Pearson, E., Lenn, N. J., & Cail, W. S. (1985) · Pediatric Neurology · doi:10.1016/0887-8994(85)90060-8 · Cited by 45 · see citing works
DOES DOWN SYNDROME SUPPORT HOMOCYSTEINE THEORY OF ARTERIOSCLEROSIS?
Brattström, L. E., Englund, E. M., & Brun, A. E. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91772-7 · Cited by 45 · see citing works
Neuroinflammatory Phenotypes and Their Roles in Alzheimer's Disease
Wilcock, D. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354228 · Cited by 41 · see citing works
Self-citation
Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy
Donahue, J. E., Khurana, J. S., & Adelman, L. S. (1998) · Acta Neuropathologica · doi:10.1007/s004010050789 · Cited by 40 · see citing works
Neuroinflammatory Cytokines - The Common Thread in Alzheimer Pathogenesis
Griffin, W. S. T., Barger, S. W., & Chairman, D. P. A. V. (2011) · European Neurological Review · doi:10.17925/enr.2011.06.02.89 · Cited by 39 · see citing works
Does Down's syndrome support the homocysteine theory of atherogenesis?
Licastro, F., Marocchi, A., Penco, S., Porcellini, E., Lio, D., Dogliotti, G., & Romanelli, M. M. C. (2006) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2006.01.003 · Cited by 39 · see citing works
Cerebral amyloid angiopathy in Down's syndrome.
Belza, M. G., & Urich, H. (1986) · PubMed · Cited by 37 · see citing works
Are Down syndrome patients predisposed to Moyamoya disease?
Fukushima, Y., Kondo, Y., Kuroki, Y., et al. (1986) · European Journal of Pediatrics · doi:10.1007/bf00441756 · Cited by 36 · see citing works
Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis.
Griffin, W. S. T., & Barger, S. W. (2010) · PubMed · Cited by 35 · see citing works
A quartet of Down's syndrome, Alzheimer's disease, cerebral amyloid angiopathy, and cerebral haemorrhage: interacting genetic risk factors
McCarron, M. O., Nicoll, J. A. R., & Graham, D. I. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.3.405 · Cited by 34 · see citing works
Neuroinflammatory Cytokines—The Common Thread in Alzheimer Pathogenesis
Griffin, W. S. T., Barger, S. W., & Chairman, D. P. A. V. (2010) · touchREVIEWS in Neurology · doi:10.17925/usn.2010.06.02.19 · Cited by 32 · see citing works
Use of Advance Directives: Facilitating Health Care Decisions by Adults With Mental Retardation and Their Families
Friedman, R. I. (1998) · Mental Retardation · doi:10.1352/0047-6765(1998)036 · Cited by 31 · see citing works
Cerebrovascular Reactivity in Young Subjects with Sleep Apnea
Buterbaugh, J., Wynstra, C., Provencio‐Dean, N., Combs, D., Gilbert, M., & Parthasarathy, S. (2015) · SLEEP · doi:10.5665/sleep.4406 · Cited by 31 · see citing works
Obesity enhances verbal memory in postmenopausal women with Down syndrome
Patel, B. N., Pang, D. I., Stern, Y., Silverman, W. P., Kline, J. K., Mayeux, R. P., & Schupf, N. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00089-7 · Cited by 30 · see citing works
Hyperlipidaemia in patients with down's syndrome
Nishida, Y., AKAOKA, I., Nishizawa, T., et al. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90090-9 · Cited by 30 · see citing works
Estrogen Receptor-α Variants Increase Risk of Alzheimer’s Disease in Women with Down Syndrome
Schupf, N., Lee, J. H., Wei, M., Pang, D. I., Chace, C., Cheng, R., Zigman, W. B., Tycko, B., & Silverman, W. P. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000126495 · Cited by 29 · see citing works
Prader-Willi-like syndrome in a patient with an Xq23q25 duplication
Monaghan, K. G., Dyke, D. L. V., & Feldman, G. L. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19981116)80:3 · Cited by 29 · see citing works
Estrogen Receptor-Beta Variants Are Associated with Increased Risk of Alzheimer’s Disease in Women with Down Syndrome
Zhao, Q., Lee, J. H., Pang, D. I., Temkin, A. M., Park, N., Janicki, S. C., Zigman, W. B., Silverman, W. P., Tycko, B., & Schupf, N. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000334522 · Cited by 27 · see citing works
Moyamoya disease and Down syndrome: case report and review of the literature.
de Borchgrave, V., Saussu, F., Depré, A., et al. (2002) · PubMed · Cited by 26 · see citing works
Cerebral amyloid angiopathy as a cause of an extensive brain hemorrhage in adult patient with Down's syndrome - a case report.
Mendel, T. A., Bertrand, E., Szpak, G. M., Stępień, T., & Wierzba‐Bobrowicz, T. (2010) · PubMed · Cited by 23 · see citing works
Autopsy findings in Down's syndrome with cerebrovascular disorder.
Nagasaka, T., Shiozawa, Z., Kobayashi, M., et al. (1996) · PubMed · Cited by 23 · see citing works
Variability of .BETA.-Amyloid Protein Deposited Lesions in Down's Syndrome Brains.
Ikeda, S.-I., Tokuda, T., Yanagisawa, N., Kametani, F., Ohshima, T., & Allsop, D. (1994) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.174.189 · Cited by 22 · see citing works
Hemorrhagic stroke, cerebral amyloid angiopathy, Down syndrome and the Boston criteria.
Jastrzębski, K., Kacperska, M., Majos, A., Grodzka, M., & Głąbiński, A. (2015) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2015.04.006 · Cited by 20 · see citing works
Cerebral amyloid angiopathy-related hemorrhage in a middle-aged patient with Down's syndrome
Naito, K., Sekijima, Y., & Ikeda, S. (2008) · Amyloid · doi:10.1080/13506120802524981 · Cited by 19 · see citing works
Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels
Tansley, G., Holmes, D. T., Lütjohann, D., Head, E., & Wellington, C. L. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/179318 · Cited by 18 · see citing works
Self-citation
On the association of moyamoya disease with Down's syndrome
Berg, J. M., & Armstrong, D. C. (1991) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1991.tb00412.x · Cited by 17 · see citing works
Multi‐infarct dementia in Down's syndrome
Collacott, R. A., Cooper, S., & Ismail, I. A. (1994) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1994.tb00375.x · Cited by 15 · see citing works
Advanced oxidation protein products (AOPP) and high-sensitive C-reactive protein (hs-CRP) in an “atheroma-free model”: Down's syndrome
Goi, G., Baquero-Herrera, C., Licastro, F., et al. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.10.019 · Cited by 14 · see citing works
The Moya-Moya syndrome: A report of two children
van Erven, P. M. M., Gabreëls, F. J. M., Thijssen, H. O. M., et al. (1982) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(82)90041-5 · Cited by 14 · see citing works
Low heart-type fatty acid binding protein level during aging may protect down syndrome people against atherosclerosis
Vianello, E., Dogliotti, G., Dozio, E., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-2 · Cited by 9 · see citing works
P4.57 STIFFNESS OF THE LARGE ARTERIES IN INDIVIDUALS WITH AND WITHOUT DOWN SYNDROME
Rodrigues, A. N., Coelho, L. O., Gonçalves, W. L. S., Vasconcellos, M., Cunha, R. S., Gouvêa, S. A., & Abreu, G. (2012) · Artery Research · doi:10.1016/j.artres.2012.09.204 · Cited by 9 · see citing works
Moyamoya Disease in an Adult With Down Syndrome: Comparison of Magnetic Resonance Angiography and Conventional Angiography
PARK, M., Raila, F. A., & RUSSELL, W. F. (1996) · Southern Medical Journal · doi:10.1097/00007611-199601000-00018 · Cited by 9 · see citing works
Untitled work
(2002) · doi:10.1352/0895-8017(2002)107

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Research works printed but not linked: 2

[59]Mantovani A Sica A Sozzani S Allavena P Vecchi A Locati M The chemokine system in diverse forms of macrophage activation and polarization Trends Immunol 2004 25 677 686 15530839
[110]Yla-Herttuala S Luoma J Nikkari T Kivimaki T Down's syndrome and atherosclerosis Atherosclerosis 1989 76 269 272 2525042

Sorted by citations

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Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947 · see citing works
Dementia in Down syndrome: unique insights for Alzheimer disease research
Lott, I. T., & Head, E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0132-6 · Cited by 383 · see citing works
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Self-citation
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Kapasi, A., Yu, L., Petyuk, V., Arfanakis, K., Bennett, D. A., & Schneider, J. A. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02397-x · Cited by 55 · see citing works

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Kirvalidze, M., Hodkinson, A., Storman, D., Fairchild, T. J., Bała, M. M., Beridze, G., Zuriaga, A., Brudasca, N. I., & Brini, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104551 · Cited by 37 · see citing works
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Authors: Wilcock, D. M., Schmitt, F. A., & Head, E.
Affiliations: University of Kentucky (US)
Corresponding author: Head, Elizabeth
ORCID: Wilcock, Donna M.
Schmitt, Frederick A.
Head, Elizabeth
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2016-05
Volume: 1862
Issue: 5
Pages: 909-914
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2015.11.007
PMC: PMC4821721
OpenAlex: W2180610334
Cited by: 56
References: 117
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 9 · 2016: 8
FWCI: 0.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health
National Institutes of Health (R01HD064993)
Alzheimer's Association (DSADNIP-13-282631)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: Down syndrome, Alzheimer's disease, cerebrovascular pathology, aging, cardiovascular dysfunction, vascular risk factors, amyloid plaques, amyloid precursor protein, comorbidities, vascular imaging, cognitive impairment, dementia
MeSH terms: Aging, Alzheimer Disease, Animals, Cerebrovascular Disorders, Down Syndrome, Humans, Amyloid beta-Peptides

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Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

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