Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
Open accessAbstract
phenothiazines.Although the first patient had no visual impairment or apraxia, computed tomographic appearances were compatible with parieto-occipital infarcts in arterial boundary zones and may have been due to hypotension.3The paroxysms of muscle spasms, tachycardia, sweating, and rage were probably due to brain-stem dysfunction analogous to the "rage reaction" produced experimentally in animals by diencephalic damage or stimulation.4The akinetic mutism, catatonic posturing, and disordered eye movements in the second patient indicated a lesion of the upper brain stem affecting the basal ganglia.5Despite systemic hypotension the clinical features described above are not those expected from lesions in arterial boundary zones but are more in keeping with damage to basal ganglia and diencephalic structures, which are lairly resistant to hypotension.Asphyxic anoxia may affect basal ganglia, and hypoxia may have caused such damage in our cases.In addition, anaphylaxis may cause vasoconstriction or increased vascular permeability, and these mechanisms may have produced lesions in the well-vascularised structures of the brain stem and basal ganglia.I thank Dr G D Schott for helpful suggestions,
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peak liver function disturbance occurs 2-4 days after paracetamol overdose, whereas renal impairment, if it develops, becomes more evident after 1 week and returns to normal about 2-3 weeks after ingestion.
“While the peak disturbance in liver function occurs 2 to 4 days after a paracetamol overdose, renal impairment, if it develops, becomes more evident after 1 week and returns to normal about 2 to 3 weeks after ingestion (55,61).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [55]
The Case reports section says renal failure was generally most evident one week after ingestion, compared with two to four days for liver damage. It does not say that renal function returned to normal about two to three weeks after ingestion; the table reports periods of oliguria, not a general time to normal renal function. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Conservative Renal Surgery for Adenocarcinoma. The Place of Bench Surgery
Wickham, J. E. A. (1975) · British Journal of Urology · doi:10.1111/j.1464-410x.1975.tb03914.x · Cited by 94 · see citing works
Kleinman, J. G., Breitenfield, R. V., & Roth, D. A. (1980) · PubMed · Cited by 79 · see citing works
The spectrum of paracetamol (acetaminophen) overdose: clinical and epidemiological studies
Hamlyn, A. N., Douglas, A. P., & James, O. (1978) · Postgraduate Medical Journal · doi:10.1136/pgmj.54.632.400 · Cited by 61 · see citing works
Hamlyn, A. N., Lesna, M., Record, C. O., Smith, P., Watson, A. J., Meredith, T. J., Volans, G. N., & Crome, P. (1981) · Journal of International Medical Research · doi:10.1177/030006058100900314 · Cited by 24 · see citing works
Self-citationWilkinson, R. W., James, O. F., Sh, R., et al. (1979) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Paracetamol: New Vistas of an Old Drug
Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., & Leone, S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00250.x · Cited by 654 · see citing works
Paracetamol Overdosage Pharmacological Considerations and Clinical Management
Prescott, L. F. (1983) · Drugs · doi:10.2165/00003495-198325030-00002 · Cited by 425 · see citing works
Acute Liver Failure Including Acetaminophen Overdose
Fontana, R. J. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.03.005 · Cited by 249 · see citing works
Acetaminophen‐Related Acute Renal Failure without Fulminant Liver Failure
Eguia, L., & Materson, B. J. (1997) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1997.tb03721.x · Cited by 126 · see citing works
Renal impairment associated with an acute paracetamol overdose in the absence of hepatotoxicity
Campbell, N. R. C., & Baylis, B. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.796.116 · Cited by 39 · see citing works
The current management of paracetamol overdosage
Makin, A., & Williams, R. (1994) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.1994.tb09786.x · Cited by 38 · see citing works
- Authors
- Cobden, I., Record, C. O., Ward, M. K., & Kerr, D. N.
- ORCID
- Ward, M K
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1982-01-02
- Volume
- 284
- Issue
- 6308
- Pages
- 21-22
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2030613763
- Cited by
- 103
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 3
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- paracetamol, acute kidney injury, drug-induced nephrotoxicity, liver injury, adverse drug reactions, phenothiazines, brainstem lesions, basal ganglia, anoxic brain injury, hypotension, anaphylaxis
- MeSH terms
- Acetaminophen, Adolescent, Adult, Female, Humans, Middle Aged, Chemical and Drug Induced Liver Injury, Acute Kidney Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
