Serum fructosamine concentrations in patients with type II (non-insulin-dependent) diabetes mellitus during changes in management
Open accessAbstract
The serum fructosamine concentration was examined as a new means to monitor metabolic control in non-insulin-dependent diabetes during changes in management. Weekly fructosamine estimations were compared with glycosylated haemoglobin (HbA1c), 24 hour urinary glucose, and fasting plasma glucose concentrations in a 17 week study entailing withdrawal and reinstitution of oral treatment. The serum fructosamine concentration was more sensitive than the other measurements in detecting a deterioration in diabetic control after stopping oral hypoglycaemic drugs. The response to reinstitution of treatment was not significant in the first three weeks (p = 0.266), despite a highly significant reduction in fasting plasma glucose (p = 0.001) and 24 hour urinary glucose concentrations (p = 0.012). Compared with HbA1c, concentrations of fructosamine appeared more useful in monitoring short term (three to six weeks) changes after alterations in management of diabetes. Additional advantages were lower cost and technical simplicity of measurement.
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- Authors
- Baker, J. R., Johnson, R. N., & Scott, D. J.
- Affiliations
- Middlemore Hospital (NZ)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1984-05-19
- Volume
- 288
- Issue
- 6429
- Pages
- 1484-1486
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2049127634
- Cited by
- 101
- References
- 21
- Citations by year
- 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- serum fructosamine, type 2 diabetes, glycemic control monitoring, glycosylated haemoglobin, fasting blood glucose, urine glucose, treatment response
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycosuria, Glycated Hemoglobin, Hexosamines, Humans, Male, Middle Aged, Time Factors, Fructosamine
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