The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.
Open accessAbstract
Sequential serum samples from 13 homosexual men who seroconverted for antibodies to human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who developed the acquired immune deficiency syndrome (AIDS), HIV antigenaemia preceded the onset of AIDS by more than a year and persisted throughout the course of the disease. This antigenaemia was accompanied by the disappearance of IgG antibody reactivity to the major HIV core protein p24. In none of the 12 others, who all remained without serious disease, were serum concentrations of HIV antigen detected, except on one occasion in one man. All their serum samples showed strong IgG antibody reactivity to p24. Nine children who were infected with HIV in 1981 by plasma transfusion from a single donor were also followed up for HIV antigenaemia. HIV antigen was almost constantly present in the serum (26 of 28 samples) of five children who developed AIDS related complex or AIDS and less often in the serum (four of 10 samples) of four children who remained free of symptoms. The two children who developed AIDS showed a virtual absence of antibody reactivity to p24. These results indicate that increased HIV gene expression is a contributing factor to the development of AIDS and also provide evidence for a switch from latent to active HIV infection.
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Cites
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Human T-lymphotropic retroviruses
Wong-Staal, F., & Gallo, R. C. (1985) · Nature · doi:10.1038/317395a0 · Cited by 612
Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV
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Self-citationInduction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency
Folks, T., Powell, D. M., Lightfoote, M. M., Benn, S., Martin, M. A., & Fauci, A. S. (1986) · Science · doi:10.1126/science.3003906 · Cited by 260
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Self-citationMELBYE, M., BIGGAR, R. J., EBBESEN, P., NEULAND, C., GOEDERT, J. J., FABER, V., LORENZEN, I., SKINHØJ, P., GALLO, R. C., & BLATTNER, W. A. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-4-496 · Cited by 162
Antibodies to the Core Protein of Lymphadenopathy-Associated Virus (LAV) in Patients with AIDS
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Cited by
Ranki, A., Krohn, M., Allain, J.-P., Franchini, G., Valle, S.-L., Antonen, J., Leuther, M., & Krohn, K. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92985-0 · Cited by 342
Statistical analysis of the stages of HIV infection using a Markov model
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Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection
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Self-citationUsing mathematical models to understand the AIDS epidemic
Hyman, J. M., & Stanley, E. A. (1988) · Mathematical Biosciences · doi:10.1016/0025-5564(88)90078-8 · Cited by 255
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Self-citation
Metadata
- Authors
- Lange, J. M., Paul, D. A., Huisman, H. G., de Wolf, F., van den Berg, H., Coutinho, R. A., Danner, S. A., van der Noordaa, J., & Goudsmit, J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1986-12-06
- Volume
- 293
- Issue
- 6560
- Pages
- 1459-1462
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W1975403569
- Cited by
- 340
- References
- 10
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lange, J. M., Paul, D. A., Huisman, H. G., de Wolf, F., van den Berg, H., Coutinho, R. A., Danner, S. A., van der Noordaa, J., & Goudsmit, J. (1986). Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS. BMJ. https://doi.org/10.1136/bmj.293.6560.1459
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
