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Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.
Open accessAbstract
Aluminium that has accumulated in the body is thought to have a generalised cytotoxic effect. A prospective study of aluminium accumulation in bone-that is, subclinical aluminium toxicity--was carried out in 94 recipients of kidney allografts, who were followed up for three years. Subclinical aluminium toxicity was found in 66 patients. A significantly smaller proportion of patients with aluminium accumulation experienced a rejection episode: 30 (58%) nu 12 (86%) who received grafts from cadavers and 4 (29%) nu 10 (71%) who received grafts from living donors. On multivariate analysis only the source of the kidney and aluminium accumulation were found to influence the rejection rate. These findings suggest that aluminium accumulation has an immunosuppressive effect.
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“Toxic exposure to Al causes immunotoxicity leading to inhibition of lymphocyte and macrophage functions (Nordal et al., 1988; Zhu et al., 2014a).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Nordal et al., 1988
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Research works printed but not linked: 17
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Cited by
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Toxic exposure to Al causes immunotoxicity leading to inhibition of lymphocyte and macrophage functions (Nordal et al., 1988; Zhu et al., 2014a).”
Background
Metadata
- Authors
- Nordal, K. P., Dahl, E., Albrechtsen, D., Halse, J., Leivestad, T., Tretli, S., & Flatmark, A.
- Affiliations
- Oslo University Hospital (NO)
- ORCID
- Tretli, S.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1988-12-17
- Volume
- 297
- Issue
- 6663
- Pages
- 1581-1582
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1835306
- OpenAlex
- W2046423168
- Cited by
- 21
- References
- 0
- Citations by year
- 2019: 1 · 2014: 1
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- aluminum accumulation, kidney transplantation, graft rejection, immunosuppression, deceased donor, living donor, cytotoxicity
- MeSH terms
- Adult, Aluminum, Bone and Bones, Cadaver, Graft Survival, Humans, Immunosuppression Therapy, Prospective Studies, Tissue Donors, Kidney Transplantation
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants. https://app.cochat.ai/papers/10.1136/bmj.297.6663.1581
- The paper
- Nordal, K. P., Dahl, E., Albrechtsen, D., Halse, J., Leivestad, T., Tretli, S., & Flatmark, A. (1988). Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants. BMJ. https://doi.org/10.1136/bmj.297.6663.1581
