Randomised clinical trials in general practice: lessons from a failure.

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

GRUPPOITALIANOPERLOSTUDIODELL (1990) · The Lancet · doi:10.1016/0140-6736(90)91589-3 · Cited by 905 · see citing works

Why do we need some large, simple randomized trials?

Yusuf, S., Collins, R., & Peto, R. (1984) · Statistics in Medicine · doi:10.1002/sim.4780030421 · Cited by 700 · see citing works

The State of the Art Versus the State of the Science: The Diffusion of New Medical Technologies into Practice

Greer, A. L. (1988) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462300003202 · Cited by 350 · see citing works

Isolated systolic hypertension in the elderly

Staessen, J. A., Amery, A., & Fagard, R. (1990) · Journal of Hypertension · doi:10.1097/00004872-199005000-00001 · Cited by 305 · see citing works

Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension

(1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90024-8 · Cited by 109 · see citing works

The Impact of Patient Management Guidelines on the Care of Breast, Colorectal, and Ovarian Cancer Patients in Italy

Grilli, R. G., Apolone, G., Marsoni, S., Nicolucci, A., Zola, P., & Liberati, A. (1991) · Medical Care · doi:10.1097/00005650-199101000-00005 · Cited by 66 · see citing works

The teaching and organisation of clinical pharmacology in European medical schools

Orme, M., Sjöqvist, F., Bircher, J., Bogaert, M., Dukes, M. N. G., Eichelbaum, M. F., Gram, L. F., Hüller, H., Lunde, I., & Tognoni, G. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf00265965 · Cited by 33 · see citing works

RESEARCH IN GENERAL PRACTICE

(1962) · The Lancet · doi:10.1016/s0140-6736(62)90911-x · Cited by 30 · see citing works

Prevalence, incidence, and hazards of hypertension in the elderly

Kannel, W. B. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90409-6 · Cited by 28 · see citing works

SECOND-GENERATION CLINICAL PHARMACOLOGY

Tognoni, G., & Bonati, M. R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92626-7 · Cited by 23 · see citing works

STOP-Hypertension--preliminary communication from the pilot study of the Swedish Trial in Old Patients with Hypertension.

Dahlöf, B., Hansson, L., Lindholm, L. H., Scherstén, B., & Po, W. (1987) · PubMed · Cited by 22 · see citing works

The case of gissi in changing the attitudes and practice of Italian cardiologists

Tognoni, G., Franzosi, M. G., Garattini, S. K., Maggioni, A. P., Lotto, A., Mauri, F., & Rovelli, F. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090108 · Cited by 19 · see citing works

Research in general practice.

Falk, W. (1979) · PubMed · Cited by 16 · see citing works

Feasibility of a large prospective study in general practice: an Italian experience. Gruppo di Studio sulla Pressione Arteriosa nell'Anziano.

Avanzini, F., Alli, C., Bettelli, G., Colombo, F., Conforti, L., Pirone, F., Spagnoli, A., Taioli, E., Tognoni, G., & Villella, M. (1987) · BMJ · doi:10.1136/bmj.294.6565.157 · Cited by 13 · see citing works

Hypertension in general practice: what is to be done?

Coope, J. (1984) · BMJ · doi:10.1136/bmj.288.6421.880 · Cited by 10 · see citing works

Awareness, treatment, and control of hypertension in the elderly in a general practice experience

Pirone, F., Radice, M., Avanzini, F., Alli, C., Bettelli, G., Colombo, F., Conforti, L., Devoto, M. A., Tullio, M. R. D., Marchioli, R., et al. (1989) · Clinical Cardiology · doi:10.1002/clc.4960120511 · Cited by 6 · see citing works

Management of acute myocardial infarction 1990: A perspective

Vogel, J. H. K. (1991) · Clinical Cardiology · doi:10.1002/clc.4960140104 · Cited by 4 · see citing works

Antihypertensive treatment of the elderly in general practice.

Villella, M., Devoto, M. A., Avanzini, F., Alli, C., Bettelli, G., Colombo, F., Tullio, M. R. D., Marchioli, R., Mariottì, G., & Radice, M. (1989) · PubMed · Cited by 1 · see citing works

Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice

Roncaglioni, M. C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03539-x · Cited by 997 · see citing works

Barriers to Participation in Randomised Controlled Trials

Ross, S., Grant, A., Counsell, C., Gillespie, W., Russell, I., & Prescott, R. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00141-9 · Cited by 907 · see citing works

Patient and service user engagement in research: a systematic review and synthesized framework

Shippee, N. D., Garces, J. P. D., López, G., Wang, Z., Elraiyah, T. A., Nabhan, M., Brito, J. P., Boehmer, K. B., Hasan, R., Firwana, B., et al. (2013) · Health Expectations · doi:10.1111/hex.12090 · Cited by 630 · see citing works

Quality improvement report Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study Commentary: presenting unbiased information to patients can be difficult

Donovan, J., Little, P., Mills, N., Smith, M., Brindle, L., Jacoby, A., Peters, T., Frankel, S., Neal, D., & Hamdy, F. (2002) · BMJ · doi:10.1136/bmj.325.7367.766 · Cited by 533 · see citing works

Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study

Campbell, M., Snowdon, C., Francis, D., Elbourne, D., McDonald, A., Knight, R., Entwistle, V, Garcia, J., Roberts, I., Grant, A., et al. (2007) · Health Technology Assessment · doi:10.3310/hta11480 · Cited by 433 · see citing works

Factors that limit the quality, number and progress of randomised controlled trials

Prescott, Counsell, Gillespie, Grant, Russell, Kiauka, Colthart, Ross, Shepherd, & Russell (1999) · Health Technology Assessment · doi:10.3310/hta3200 · Cited by 390 · see citing works

Making sense of randomization; responses of parents of critically ill babies to random allocation of treatment in a clinical trial

Snowdon, C., Garcia, J., & Elbourne, D. (1997) · Social Science & Medicine · doi:10.1016/s0277-9536(97)00063-4 · Cited by 296 · see citing works

Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR)

Blanchon, T., Bréchot, J.-M., Greniér, P., Ferretti, G., Lemarié, É., Milleron, B. J., Chagué, D., Laurent, F., Martinet, Y., Beigelman‐Aubry, C., et al. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2007.05.009 · Cited by 272 · see citing works

Physician participation in clinical research and trials: issues and approaches

Rahman, S., Majumder, M. A. A., Shaban, S. F., Rahman, N., Ahmed, S. M., Abdulrahman, K. A. B., & D’Souza (2011) · Advances in Medical Education and Practice · doi:10.2147/amep.s14103 · Cited by 182 · see citing works

Occupational therapy for stroke patients not admitted to hospital: a randomised controlled trial.

Walker, M., Gladman, J., Lincoln, N. B., Siemonsma, P., & Whiteley, T. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11128-5 · Cited by 198 · see citing works

Involving South Asian patients in clinical trials

Hussain‐Gambles, M., Leese, B., Atkin, K. M., Brown, J. M., Mason, S. M., & Tovey, P. (2004) · Health Technology Assessment · doi:10.3310/hta8420 · Cited by 172 · see citing works

Problems with Recruitment in a Randomized Controlled Trial of Counselling in General Practice: Causes and Implications

真栄里, 愛., & Dowrick, C. F. (1996) · Journal of Health Services Research & Policy · doi:10.1177/135581969600100205 · Cited by 167 · see citing works

Recruiting patients into a primary care based study of palliative care: why is it so difficult?

Ewing, G., Rogers, M., Barclay, S. I. G., McCabe, J., Martin, A., & Todd, C. J. (2004) · Palliative Medicine · doi:10.1191/0269216304pm905oa · Cited by 167 · see citing works

How evidence based are recruitment strategies to randomized controlled trials in primary care? Experience from seven studies

Foy, R. (2003) · Family Practice · doi:10.1093/fampra/20.1.83 · Cited by 160 · see citing works

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials

van Staa, T. P., Dyson, L., McCann, G., Padmanabhan, S., Belatri, R., Goldacre, B. M., Cassell, J., Pirmohamed, M., Torgerson, D. J., Ronaldson, S. J., et al. (2014) · Health Technology Assessment · doi:10.3310/hta18430 · Cited by 154 · see citing works

A randomised controlled trial and economic evaluation of a referrals facilitator between primary care and the voluntary sector

Grant, C. (2000) · BMJ · doi:10.1136/bmj.320.7232.419 · Cited by 150 · see citing works

Corticosteroid Injections for Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial in Primary Care

Brinks, A., van Rijn, R. M., Willemsen, S. P., Bohnen, A. M., Verhaar, J. A. N., Koes, B. W., & Bierma‐Zeinstra, S. (2011) · The Annals of Family Medicine · doi:10.1370/afm.1232 · Cited by 144 · see citing works

Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study

Mills, N., Donovan, J. L., Smith, M., Jacoby, A., Neal, D. E., & Hamdy, F. C. (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00020-5 · Cited by 142 · see citing works

Social and psychological factors influenced the course of arm, neck and shoulder complaints

Karels, C. H., Bierma-Zeinstra, S. M. A., Burdorf, A., Verhagen, A. P., Nauta, A. P., & Koes, B. W. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.11.012 · Cited by 140 · see citing works

Survey among 78 studies showed that Lasagna's law holds in Dutch primary care research

van der Wouden, J. C., Blankenstein, A. H., Huibers, M. J. H., van der Windt, D. A. W. M., Stalman, W. A. B., & Verhagen, A. P. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.11.010 · Cited by 122 · see citing works

GPs' experiences of primary care mental health research: a qualitative study of the barriers to recruitment

Mason, V. L., Shaw, A. R. G., Wiles, N., Mulligan, J., Peters, T., Sharp, D., & Lewis, G. (2007) · Family Practice · doi:10.1093/fampra/cmm047 · Cited by 112 · see citing works

Randomised controlled trials in primary care: case study

Wilson, S., Delaney, B. C., Roalfe, A. K., Roberts, L. M., Redman, V., Wearn, A. M., & Hobbs, R. F. (2000) · BMJ · doi:10.1136/bmj.321.7252.24 · Cited by 108 · see citing works

Prospective controlled evaluation of the effect of a community based asthma education centre in a multiracial working class neighbourhood.

Garrett, J., Fenwick, J., Taylor, G., Mitchell, E., Stewart, J., & Rea, H. H. (1994) · Thorax · doi:10.1136/thx.49.10.976 · Cited by 105 · see citing works

Recruiting patients to randomized trials in primary care: principles and case study

Bell-Syer, S. E., & Moffett, J. A. K. (2000) · Family Practice · doi:10.1093/fampra/17.2.187 · Cited by 92 · see citing works

Practical aspects of conducting a pragmatic randomised trial in primary care: patient recruitment and outcome assessment.

van der Windt, D., Koes, B. W., van Aarst, M., Heemskerk, M. A. M. B., & Bouter, L. M. (2000) · Europe PMC (PubMed Central) · Cited by 78 · see citing works

Who can best recruit to randomized trials?

Donovan, J., Peters, T. J., Noble, S., Powell, P. H., Gillatt, D. A., Oliver, S. E., Lane, J. A., Neal, D. E., & Hamdy, F. C. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00083-0 · Cited by 77 · see citing works

Zelen Randomization

Snowdon, C., Elbourne, D., & Garcia, J. (1999) · Controlled Clinical Trials · doi:10.1016/s0197-2456(98)00049-x · Cited by 74 · see citing works

Randomised controlled trials in general practice

Pringle, M., & Churchill, D. (1995) · BMJ · doi:10.1136/bmj.311.7017.1382 · Cited by 74 · see citing works

Importance and Challenges of Studying Marketed Drugs: What Is a Phase IV Study? Common Clinical Research Designs, Registries, and Self‐Reporting Systems

Glasser, S. P., Salas, M., & Delzell, E. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007304776 · Cited by 73 · see citing works

The challenge of recruiting patients with anterior cruciate ligament injury of the knee into a randomized clinical trial comparing surgical and non-surgical treatment

Frobell, R. B., Lohmander, S. L., & Roos, E. M. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2006.10.002 · Cited by 67 · see citing works

Development and evaluation of culturally sensitive psychosocial interventions for under-served people in primary care

Lovell, K., Lamb, J., Gask, L., Bower, P., Waheed, W., Chew-Graham, C., Lamb, J., Aseem, S., Beatty, S., Burroughs, H., et al. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0217-8 · Cited by 53 · see citing works

Randomised trials in general practice--a New Zealand experience in recruitment.

Pearl, A., Wright, S. J., Gamble, G. D., Doughty, R., & Sharpe, N. (2003) · PubMed · Cited by 56 · see citing works

Management of acute neck pain in general practice: a prospective study.

Vos, C. J., Verhagen, A. P., Passchier, J., & Koes, B. W. (2007) · PubMed Central · Cited by 55 · see citing works

Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality

Eurich, D. T., Tsuyuki, R. T., Majumdar, S. R., McAlister, F. A., Lewanczuk, R. Z., Shibata, M. C., & Johnson, J. A. (2009) · Trials · doi:10.1186/1745-6215-10-12 · Cited by 54 · see citing works

Conducting randomized trials in general practice: methodological and practical issues.

Ward, E. S., King, M., Lloyd, M., Bower, P., & Friedli, K. (1999) · Europe PMC (PubMed Central) · Cited by 55 · see citing works

A qualitative evaluation of implementing a randomized controlled trial in general practice

Prout, H. (2003) · Family Practice · doi:10.1093/fampra/cmg609 · Cited by 53 · see citing works

An assessment of willingness to participate in a randomized trial of arthroscopic knee surgery in patients with osteoarthritis

Creel, A. H., Losina, E., Mandl, L. A., Marx, R. G., Mahomed, N. N., MARTIN, S. D., Martin, T. L., Millett, P. J., Fossel, A. H., & Katz, J. N. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2004.12.010 · Cited by 53 · see citing works

Controlled trials in the evaluation of counselling in general practice.

King, M., Broster, G., Lloyd, M., & Horder, J. (1994) · Europe PMC (PubMed Central) · Cited by 53 · see citing works

Clinical trials in primary care

Foy, R., Parry, J. M., & McAvoy, B. (1998) · BMJ · doi:10.1136/bmj.317.7167.1168 · Cited by 50 · see citing works

Applying the results of clinical trials to patients to general practice: perceived problems, strengths, assumptions, and challenges for the future.

Fahey, T. P. (1998) · PubMed Central · Cited by 47 · see citing works

Do doctors know best? Comments on a failed trial

Hunt, C. J., Andrews, G., & Shepherd, L. M. (2001) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2001.tb143189.x · Cited by 48 · see citing works

Recruitment into a guided internet based CBT (iCBT) intervention for depression: Lesson learnt from the failure of a prevalence recruitment strategy

Woodford, J., Farrand, P. A., Bessant, M., & Williams, C. M. (2011) · Contemporary Clinical Trials · doi:10.1016/j.cct.2011.04.013 · Cited by 48 · see citing works

Recruiting family physicians and patients for a clinical trial: lessons learned

Sellors, J. W. (2002) · Family Practice · doi:10.1093/fampra/19.1.99 · Cited by 48 · see citing works

Payment to healthcare professionals for patient recruitment to trials: systematic review and qualitative study

Raftery, J. P., Bryant, J., powell, J. A., Kerr, C., & Hawker, S. (2008) · Health Technology Assessment · doi:10.3310/hta12100 · Cited by 45 · see citing works

The Patient Deficit Model Overturned: a qualitative study of patients' perceptions of invitation to participate in a randomized controlled trial comparing selective bladder preservation against surgery in muscle invasive bladder cancer (SPARE, CRUK/07/011)

SPARE Trial Management Group, Moynihan, C., Lewis, R., Hall, E., Jones, E., Birtle, A. J., & Huddart, R. A. (2012) · Trials · doi:10.1186/1745-6215-13-228 · Cited by 42 · see citing works

The content and methodology of research papers published in three United Kingdom primary care journals.

Thomas, T., Fahey, T. P., & Somerset, M. (1998) · PubMed Central · Cited by 42 · see citing works

Can support and education for smoking cessation and reduction be provided effectively by midwives within primary maternity care?

McLeod, D. L., Pullon, S. R. H., Benn, C., Cookson, T., Dowell, A. C., Viccars, A., White, S., Green, R., & Crooke, M. J. (2004) · Midwifery · doi:10.1016/s0266-6138(03)00051-2 · Cited by 42 · see citing works

GP Participation and Recruitment of Patients to RCTs: Lessons from Trials of Acupuncture and Exercise for Low Back Pain in Primary Care

Bell-Syer, S. E., Thorpe, L. N., Thomas, K. J., & MacPherson, H. (2008) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen044 · Cited by 40 · see citing works

Capturing users’ experiences of participating in cancer trials

Donovan, J., Brindle, L. A., & Mills, N. (2002) · European Journal of Cancer Care · doi:10.1046/j.1365-2354.2002.00341.x · Cited by 39 · see citing works

Recruitment and Retention of Physicians for Primary Care Research

Shelton, B. J., Wofford, J. L., Gosselink, C. A., McClatchey, M. W., Brekke, K. L., Conry, C. M., Wolfe, P., & Cohen, S. J. (2002) · Journal of Community Health · doi:10.1023/a:1014598332211 · Cited by 38 · see citing works

An alternative trial design to overcome validity and recruitment problems in primary care research

Huibers, M. J. H. (2004) · Family Practice · doi:10.1093/fampra/cmh219 · Cited by 36 · see citing works

Dyspeptic symptoms in primary care. An observational study in general practice

Maconi, G., Tosetti, C., Stanghellini, V., Porro, G. B., & Corinaldesi, R. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200209000-00009 · Cited by 35 · see citing works

Patient involvement in qualitative data analysis in a trial of a patient‐centred intervention: Reconciling lay knowledge and scientific method

Frost, J., Gibson, A., Harris‐Golesworthy, F., Harris, J., & Britten, N. (2018) · Health Expectations · doi:10.1111/hex.12814 · Cited by 33 · see citing works

The feasibility of a randomised, placebo-controlled clinical trial of homeopathic treatment of depression in general practice

Katz, T., Fisher, P., Katz, A., Davidson, J. R. T., & Feder, G. S. (2005) · Homeopathy · doi:10.1016/j.homp.2005.04.002 · Cited by 31 · see citing works

Qualitative research in evidence-based medicine: Improving decision-making and participation in randomized controlled trials of cancer treatments

Audrey, S. (2011) · Palliative Medicine · doi:10.1177/0269216311419548 · Cited by 31 · see citing works

What are potential barriers and enablers to patient and physician participation in Canadian cell therapy trials for stroke? A stakeholder interview study

Lalu, M. M., Foster, M., Presseau, J., Dowlatshahi, D. D., Castillo, G., Cardenas, A., Tam, W., Zlepnig, J., Timpson, D., Dong, Y., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034354 · Cited by 27 · see citing works

Increasing equity of access to high-quality mental health services in primary care: a mixed-methods study

Dowrick, C., Chew-Graham, C., Lovell, K., Lamb, J., Aseem, S., Beatty, S., Bower, P., Burroughs, H., Clarke, P., Edwards, S., et al. (2013) · Programme Grants for Applied Research · doi:10.3310/pgfar01020 · Cited by 27 · see citing works

Factors affecting patient recruitment to trials: qualitative research in general practice

van den Brink, M. J., Hummel, M. E., Lemstra, M., Berger, M. Y., Dekker, J. H., & Blanker, M. H. (2020) · BJGP Open · doi:10.3399/bjgpopen20x101056 · Cited by 31 · see citing works

Baseline characteristics and comparability of older multimorbid patients with polypharmacy and general practitioners participating in a randomized controlled primary care trial

Jungo, K. T., Meier, R., Valeri, F., Schwab, N., Schneider, C., Reeve, E., Spruit, M. R., Schwenkglenks, M. M., Rodondi, N., & Streit, S. (2021) · BMC Family Practice · doi:10.1186/s12875-021-01488-8 · Cited by 25 · see citing works

Recruitment of Spinal Cord Injury Patients to Clinical Trials: Challenges and Solutions

Cardenas, D. D., & Yılmaz, B. (2005) · Topics in Spinal Cord Injury Rehabilitation · doi:10.1310/faeh-ygyj-q4lf-0x6w · Cited by 25 · see citing works

Equipoise: a case study of the views of clinicians involved in two neonatal trials

Garcia, J., Elbourne, D. R., & Snowdon, C. (2004) · Clinical Trials · doi:10.1191/1740774504cn020xx · Cited by 25 · see citing works

Recruitment strategies for a clinical trial of community-based water therapy for osteoarthritis.

Davey, R., Edwards, S. M., & Cochrane, T. (2003) · Europe PMC (PubMed Central) · Cited by 25 · see citing works

Impact of study design on recruitment of patients to a primary care trial: an observational time series analysis of the Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Study

Fletcher, K., Mant, J., Roalfe, A. K., & Hobbs, R. F. (2010) · Family Practice · doi:10.1093/fampra/cmq050 · Cited by 23 · see citing works

Recruitment for a clinical trial of chronic disease self-management for older adults with multimorbidity: a successful approach within general practice

Reed, R. L., Barton, C., Isherwood, L., Baxter, J. M. O., & Roeger, L. S. (2013) · BMC Family Practice · doi:10.1186/1471-2296-14-125 · Cited by 22 · see citing works

Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups

das Nair, R., Orr, K. S., Vedhara, K., & Kendrick, D. (2014) · Trials · doi:10.1186/1745-6215-15-98 · Cited by 22 · see citing works

Avoiding the pitfalls of sponsored multicentre research in general practice.

Waldron, H. A., & Cookson, R. F. (1993) · BMJ · doi:10.1136/bmj.307.6915.1331 · Cited by 21 · see citing works

Randomised clinical trials in general practice.

Jonker, P. L., & Sumajow, C. A. (1992) · BMJ · doi:10.1136/bmj.304.6825.508 · Cited by 20 · see citing works

Discontinuation of a randomised controlled trial in general practice due to unsuccessful patient recruitment

van der Gaag, W. H., van den Berg, R., Koes, B. W., Bohnen, A. M., Hazen, L. G. M., Peul, W. C., Voogt, L., Verhagen, A. P., Bierma‐Zeinstra, S., & Luijsterburg, P. A. J. (2017) · BJGP Open · doi:10.3399/bjgpopen17x101085 · Cited by 19 · see citing works

Feasibility and acceptability of breath research in primary care: a prospective, cross-sectional, observational study

Woodfield, G., Belluomo, I., Boshier, P. R., Waller, A., Fayyad, M., von Wagner, C., Cross, A. J., & Hanna, G. B. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-044691 · Cited by 18 · see citing works

Investigator barriers and preferences to conduct clinical drug trials in Finland: a qualitative study

Keinonen, T., Keränen, T., Klaukka, T., Saano, V., Ylitalo, P., & Enlund, H. (2003) · Pharmacy World & Science · doi:10.1023/b:phar.0000006517.36241.a5 · Cited by 11 · see citing works

Home care for heart failure: can caregiver education prevent hospital admissions? A randomized trial in primary care

Padula, M. S., DʼAmbrosio, G., Tocci, M., D’Amico, R., Banchelli, F., Angeli, L., Scarpa, M., Capelli, O., Cricelli, C. A., & Boriani, G. (2018) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000722 · Cited by 18 · see citing works

Methodological problems in dementia research in primary care: a case study of a randomized controlled trial

Wilcock, J., Bryans, M., Turner, S., O’Carroll, R. E., Keady, J. D., Levin, E., Iliffe, S., & DOWNS, M. G. (2007) · Primary Health Care Research & Development · doi:10.1017/s1463423607000035 · Cited by 18 · see citing works

A survey of statistics in three UK general practice journal

Rigby, A. S., Armstrong, G., Campbell, M. J., & Summerton, N. (2004) · BMC Medical Research Methodology · doi:10.1186/1471-2288-4-28 · Cited by 17 · see citing works

Effective and cost-effective clinical trial recruitment strategies for postmenopausal women in a community-based, primary care setting

Butt, D. A., Lock, M. I., & Harvey, B. J. (2010) · Contemporary Clinical Trials · doi:10.1016/j.cct.2010.06.003 · Cited by 17 · see citing works

Using postal randomization to replace telephone randomization had no significant effect on recruitment of patients

Brealey, S., Atwell, C., Bryan, S., Coulton, S., Cox, H., Cross, B., Fylan, F., Garratt, A., Gilbert, F. J., Gillan, M. G., et al. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.04.003 · Cited by 15 · see citing works

Public Mental Health: Global Perspectives

Knifton, L., & Quinn, N. (2013) · Cited by 15 · see citing works

A review of methodologies for assessing drug effectiveness and a new proposal: randomized database studies

Sacristán, J. A., Soto, J., Galende, I., & Hylan, T. R. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80022-7 · Cited by 14 · see citing works

Unerupted maxillary primary canine associated with compound composite odontoma: a case report.

Das, U. M., Nagarathna, & Arathi (2002) · PubMed · Cited by 12 · see citing works

De deelname van huisartsen aan wetenschappelijk onderzoekmethodologie onderzoek wetenschappelijk onderzoek

Huibers, M. J. H., van der Windt, D., & Boeke, J. (2002) · Huisarts en Wetenschap · doi:10.1007/bf03082886 · Cited by 12 · see citing works

Primary care as a permanent setting for research

Tognoni, G., Caimi, V., Tombesi, M., & Visentin, G. (2012) · Primary Health Care Research & Development · doi:10.1017/s1463423611000545 · Cited by 10 · see citing works

Partnering with mental health providers: A guide for services researchers

Frounfelker, R. L., Ben‐Zeev, D., Kaiser, S. M., O'Neill, S. J., Reedy, W., & Drake, R. E. (2012) · Journal of Mental Health · doi:10.3109/09638237.2012.705923 · Cited by 10 · see citing works

Achieving target recruitment in a primary care trial: lessons from PRIDE

Chew-Graham, C. A., Lovell, K., Roberts, C., Baldwin, B., Morley, M., Burns, A. S., & Burroughs, H. (2007) · Primary Health Care Research & Development · doi:10.1017/s146342360700031x · Cited by 9 · see citing works

A Technical Infrastructure to Conduct Randomized Database Studies Facilitated by a General Practice Research Database: Figure 1

Mosis, G., Vlug, A. E., Mosseveld, M., Dieleman, J. P., Stricker, B. H. C., van der Lei, J., & Sturkenboom, M. (2005) · Journal of the American Medical Informatics Association · doi:10.1197/jamia.m1803 · Cited by 9 · see citing works

Drug Utilisation Review and Pharmacoeconomics

Garattini, S. K., & Tognoni, G. (1993) · PharmacoEconomics · doi:10.2165/00019053-199304030-00002 · Cited by 9 · see citing works

Flourishing and job satisfaction in employees working in UK clinical trial units: a national cross-sectional survey

Hall, S. S., Riga, E., Sprange, K., Hagan, P., Carr, L., Taylor, J., Thomson, L., & Mitchell, E. J. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11986-x · Cited by 8 · see citing works

How informed general practitioners manage mild hypertension: a survey of readers of drug bulletins in 7 countries

Avanzini, F., Tognoni, G., Colombo, F., Alli, C., & Herxheimer, A. (1996) · European Journal of Clinical Pharmacology · doi:10.1007/bf00195929 · Cited by 8 · see citing works

The challenges of cross-national research in primary health care across Europe

Dean, S., Harper, C. E., Cappuccio, F. P., Rink, E., Dirckx, C., Arnout, J., Zito, F., & Iacoviello, L. (2005) · Family Practice · doi:10.1093/fampra/cmi008 · Cited by 8 · see citing works

Randomized clinical trials in clinical practice.

Peto, V., & Coulter, A. (1991) · BMJ · doi:10.1136/bmj.303.6816.1549-c · Cited by 8 · see citing works

Research Staff Perspectives on Cancer Clinical Trials and Barriers to Recruitment: A Qualitative Research

Keruakous, A. R., Day, S., Garcia-Ramiu, K. D., Yarbrough, M., & Asch, A. S. (2021) · Cureus · doi:10.7759/cureus.17202 · Cited by 7 · see citing works

Perception des essais cliniques par les patients et les investigateurs : revue bibliographique (1re partie)

Henry, A., Corvaisier, S., Blanc, S., Berthézène, F., Borson‐Chazot, F., Broussolle, E., Ryvlin, P., & Touboul, P. (2006) · Therapies · doi:10.2515/therapie:2006072 · Cited by 7 · see citing works

Recruiting and retaining general practitioners to a primary care asthma-intervention study in Australia

Shah, S., Roydhouse, J. K., Toelle, B. G., Mellis, C. M., Jenkins, C. R., Edwards, P., & Sawyer, S. M. (2012) · Australian Journal of Primary Health · doi:10.1071/py12093 · Cited by 7 · see citing works

Recruiting opiate users to a randomized controlled trial in primary care: a descriptive study of GP attitudes

Sheard, L., Tompkins, C. N. E., Wright, N. M. J., & Adams, C. E. (2006) · Primary Health Care Research & Development · doi:10.1191/1463423606pc274oa · Cited by 7 · see citing works

Clinical trials in general practice.

Greenberg, G. M. (1991) · BMJ · doi:10.1136/bmj.303.6808.940 · Cited by 7 · see citing works

Process Evaluation of Recruitment for a Cancer Screening Trial in Primary Care

James, A. S., Daley, C. M., Engelman, K. K., Greiner, K. A., & Ellerbeck, E. F. (2011) · Health Promotion Practice · doi:10.1177/1524839910366402 · Cited by 6 · see citing works

Dental practitioner recruitment for a randomized clinical trial in the field to evaluate the performance of a new glass ionomer restoration material

Klinke, T. U., Daboul, A., Schwahn, C., Frankenberger, R., Hickel, R., & Biffar, R. (2016) · Trials · doi:10.1186/s13063-016-1198-3 · Cited by 6 · see citing works

Practical aspects to undertaking research in the primary care setting: experience from two studies

Hichens, L. P. Y., Sandy, J. R., Rowland, H. N., McNair, A., Clark, S., Hills, D., Huntley, P., Ransome, S., Forty, M., Peak, J., et al. (2005) · Journal of Orthodontics · doi:10.1179/146531205225021240 · Cited by 6 · see citing works

Contrasting approaches to recruitment in primary care research

Ward, E. S., Miller, J., Graffy, J., & Bower, P. (2009) · Primary Health Care Research & Development · doi:10.1017/s1463423609990223 · Cited by 6 · see citing works

Maximising recruitment of research participants into a general practice based randomised controlled trial concerning lung diagnosis—staff insights from an embedded qualitative study

Prout, H., Tod, A., Neal, R. D., & Nelson, A. (2022) · Trials · doi:10.1186/s13063-022-06125-y · Cited by 5 · see citing works

Programme Grants for Applied Research

Library, N. J. (2012) · Cited by 5 · see citing works

Clinical Research after Drug Approval: What is Needed and What is Not

Decoster, G., & Buyse, M. E. (1999) · Drug Information Journal · doi:10.1177/009286159903300232 · Cited by 5 · see citing works

Randomised clinical trials in general practice.

Jonker, P. L., & Sumajow, C. A. (1992) · BMJ · doi:10.1136/bmj.304.6825.508 · Cited by 20 · see citing works

Randomized clinical trials in general practice.

Gunawardena, K. A., McMahon, M. T., O'Donnell, J., & Robinson, P. (1992) · BMJ · doi:10.1136/bmj.304.6821.257 · Cited by 1 · see citing works

Randomised controlled trials in general practice.

Paterson, S. M. (2000) · Europe PMC (PubMed Central)

Randomised controlled trials in general practice: Are preferable to observational studies

Fahey, T. P. (1996) · BMJ · doi:10.1136/bmj.312.7033.779 · Cited by 8 · see citing works

Trial and error: challenges conducting pragmatic trials in general practice

Wallis, K. A., & Elley, C. R. (2022) · British Journal of General Practice · doi:10.3399/bjgp22x718289 · Cited by 5 · see citing works