Cited by 17Endometriosis Research and TreatmentPoisoning and overdose treatmentsDrug-Induced Hepatotoxicity and Protection

Endometriosis.

Open access
Thomas, E J·1993·BMJ

Abstract

encourage more people to take an overdose.It should, however, reduce the likelihood of an accidental overdose being taken from severe pain and increase the chance that if a patient's family knows of the overdose they will encourage him or her to seek prompt medical advice.The pharmaceutical industry is in a pivotal position to address the problem of the continuing high mortality from paracetamol overdose as the addition of an antidote, such as methionine, to all available preparations might prevent every death that currently occurs.At present paracetamol- methionine combinations are costly, little publicised, and rarely prescribed.Adding methionine to all preparations of paracetamol might increase prices and therefore reduce sales.Another solution might be to develop non-hepatotoxic derivatives of paracetamol.It will indeed be tragic if the mortality from paracetamol overdose over the next quarter of a century proves to be as high as that of the last.

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Crossref · 10.1136/bmj.306.6871.158

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Research works printed but not linked: 16

  1. Office of Population Censuses and Surveys. Mortality statistics: cause. Review of the registrar general on deaths by cause, sex and age, in England and Wales. London: HMSO, 1989. (Series DH2 No 15.)
  2. Nelson SD. Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 1990;10:267-78.
  3. Raucy JL, Lasker JM, Lieber CS, Black M. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys 1989;271:270-83.
  4. Laskin DL. Nonparenchymal cells and hepatotoxicity. Semin LiverDis 1990;10:293-304.
  5. Prescott LF. Effects of non-narcotic analgesics on the liver. Drugs 1986;32:129-47.
  6. Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-7.
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  8. Bray GP, Harrison PM, O'Grady JG, Tredger JM, Williams R. Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 1992;11: 265-70.
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  10. Read RB, Tredger JM, Williams R. Analysis of factors responsible for continuing mortality after paracetamol overdose. Hum Toxicol 1986;5:201-6.
  11. Parker D, White JP, Paton D, Routledge PA. Safety of late acetylcysteine treatment in paracetamol poisoning. Hum Exp Toxicol 1990;9:25-7.
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  13. Harrison PM, Keays R, Bray GP, Alexander GJM, Williams R. Improved outcome of paracetamol- induced fulninant hepatic failure by late administration of acetylcysteine. Lancet 1990;335: 1572-3.
  14. Keays R, Harrison PM, Wendon JA, Forbes A, Gore C, Alexander GJM, et al. Intravenous acetylcysteire in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991;303:1026-9.
  15. Harrison PM Wendon JA, Gimson AES, Alexander GJM, Williams R. Improvement by acetylcysteirte of haemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991;304:1852-7.
  16. O'Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989;97:439-45.

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Authors
Thomas, E. J.
Corresponding author
Thomas, E J
Venue
BMJ
Publisher
BMJ
Published
1993-01-16
Volume
306
Issue
6871
Pages
158-159
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
OpenAlex
W4242782647
Cited by
17
References
14
Citations by year
2023: 1 · 2019: 4 · 2012: 1
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
endometriosis
MeSH terms
Endometriosis, Female, Humans, Pelvic Neoplasms

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