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Cited by 104Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

Double blind trial of repeated treatment with transdermal nicotine for relapsed smokers

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Gourlay, Steven G, Forbes, Andrew, Forbes, Andrew, Marriner, Tracey, Pethica, Damian, McNeil, John J·1995·BMJ
DOI 10.1136/bmj.311.7001.363PMC PMC2550432
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Abstract

OBJECTIVE: To assess the efficacy and safety of a repeat course of treatment with transdermal nicotine for cessation of smoking in a brief intervention setting. STUDY DESIGN: Randomised, double blind, placebo controlled trial with follow up for 26 weeks. SUBJECTS: 629 smokers who had unsuccessfully attempted to stop smoking by using active transdermal nicotine and brief behavioural counselling. Smokers were motivated to quit smoking for a second time and smoked > or = 15 cigarettes a day. INTERVENTIONS: Twelve weeks' treatment with active transdermal nicotine patches or placebo and brief counselling at monthly visits. MAIN OUTCOME MEASURE: Sustained smoking cessation for the 28 days before the visit at week 12 verified by expired carbon monoxide concentrations. RESULTS: At 12 weeks 21/315 (6.7%) subjects allocated to active treatment had stopped smoking compared with 6/314 (1.9%) allocated to placebo (absolute difference 4.7%; 95% confidence interval 1.6% to 7.9%; P = 0.003). At 26 weeks the rates were 20/315 (6.4%) and 8/314 (2.6%) (3.8%; 0.6% to 7.0%; P = 0.021). Difficulty in sleeping was reported by 43/179 (24.0%) on active treatment and 19/143 (13.3%) on placebo (P = 0.015). Severe reactions at the site of application were rare (6/322; 1.9%). CONCLUSIONS: Repeated treatment with transdermal nicotine together with brief counselling can improve the low success rates of smoking cessation in recently relapsed, moderate to heavy smokers. Questions remain about whether more intensive interventions or higher doses of nicotine could be more effective. The likelihood of severe reactions at the site of application with repeated treatment is low.

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  • Repeated use of the nicotine patch shortly after prior cessation failure with the patch did not lead to significant cessation rates (0% to 1.6% sustained abstinence at 26 weeks).

    “To date, repeated use of the nicotine patch shortly after prior cessation failure with the patch did not lead to significant cessation rates (0% to 1.6% sustained abstinence at 26 weeks, (120, 121).”

    From Tobacco addiction (2008) · cites this paper as [120]

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Authors
Gourlay, S. G., Forbes, A., Forbes, A., Marriner, T., Pethica, D., & McNeil, J. J.
Affiliations
Monash University (AU)
ORCID
Venue
BMJ
Publisher
BMJ
Published
1995-08-05
Volume
311
Issue
7001
Pages
363-366
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.311.7001.363
PMC
PMC2550432
OpenAlex
W2046936720
Cited by
104
References
18
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 9
FWCI
1.99
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
transdermal nicotine, smoking cessation, relapse, nicotine patch, nicotine replacement therapy, sustained abstinence, sleep disorders, heavy smokers
MeSH terms
Administration, Cutaneous, Adult, Counseling, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Nicotine, Patient Compliance, Recurrence, Weight Gain, Smoking Cessation, Treatment Outcome

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