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Cited by 54Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

Successful treatment with a nicotine lozenge of smokers with prior failure in pharmacological therapy

Shiffman, Saul, Dresler, Carolyn M., Rohay, Jeffrey M.·2004·Addiction
DOI 10.1111/j.1360-0443.2004.00576.x
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Abstract

AIMS: To assess the influence of unsuccessful past quit attempts using pharmacological treatment on smoking cessation when using a new nicotine lozenge. DESIGN: A double-blind, randomized, placebo-controlled trial. SETTING: Fifteen sites in the United Kingdom and the United States. PARTICIPANTS: A total of 1818 smokers seeking smoking cessation treatment; 1145 had had previous pharmacological treatment for smoking cessation. INTERVENTION: Lozenge, 2 mg or 4 mg (or matched placebo); a higher dose was assigned to smokers who smoked their first cigarette of the day within 30 minutes, a sign of dependence. Smokers received minimal instruction and counseling. MEASUREMENT: Outcome was 28-day, CO-verified continuous abstinence at 6 weeks. Past use of medications was ascertained by self-report. FINDINGS: Lozenge was efficacious among smokers with prior pharmacotherapy as well as among those without such history. The effect of lozenge (versus placebo) was significantly greater among those with previous treatment experience, because previous treatment was associated with significantly poorer outcome on placebo, and active lozenge treatment corrected this imbalance. Lozenge efficacy was similar whether smokers had previously tried patch or acute forms of nicotine replacement therapy (gum, inhaler and spray), and also similar for past use of Zyban (bupriopion). CONCLUSIONS: Smokers with a history of past failure of pharmacological treatment have lower success rates without pharmacological treatment, but equally good outcomes with active lozenge treatment. Smokers who previously tried pharmacological treatments but resumed smoking should be encouraged to try quitting again with the new nicotine lozenge.

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  • Smokers who reported previous use of medications (nicotine gum, patch, inhaler and bupropion) showed as much success with nicotine lozenge compared to placebo as those who did not have a previous history with smoking cessation medications.

    “A recent study showed that smokers who reported previous use of medications (nicotine gum, patch, inhaler and bupropion) showed as much success with nicotine lozenge compared to placebo as those who did not have a previous history with smoking cessation medications (123).”

    From Tobacco addiction (2008) · cites this paper as [123]

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Authors
Shiffman, S., Dresler, C. M., & Rohay, J. M.
Affiliations
  • University of Pittsburgh (US)
  • GlaxoSmithKline (United States) (US)
  • Pinney Associates (United States) (US)
Corresponding author
Shiffman, Saul
ORCID
Shiffman, Saul
Venue
Addiction
Publisher
Wiley
Published
2003-12-17
Volume
99
Issue
1
Pages
83-92
ISSN
  • 0965-2140 (ISSN-L)
  • 1360-0443
DOI
10.1111/j.1360-0443.2004.00576.x
OpenAlex
W2022842771
Cited by
54
References
32
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 3 · 2012: 2
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Addiction (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
nicotine lozenges, smoking cessation, nicotine replacement therapy, prior treatment failure, bupropion, nicotine dependence, continuous abstinence
MeSH terms
Smoking Prevention, Double-Blind Method, Female, Humans, Male, Nicotine, Tablets, Smoking Cessation, Treatment Failure, Nicotinic Agonists

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