Cited by 592Helicobacter pylori-related gastroenterology studiesCardiovascular Health and Risk FactorsAtherosclerosis and Cardiovascular Diseases

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Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

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Patel, P, Mendall, M A, Carrington, D, Strachan, D P, Leatham, E, Molineaux, N, Levy, J, Blakeston, C, Seymour, C A, Camm, A J, Northfield, T C·1995·BMJ

DOI 10.1136/bmj.311.7007.711PMC PMC2550716

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Abstract

Objective: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Objective:To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Setting: General practices in Merton, Sutton, and Wandsworth, south London. Subjects: 388 white south London men aged 50-69. Main outcome measures: Evidence of coronary risk factors and infection with H pylori or C pneumoniae. Results: 47 men (12.1%) had electrocardiographic evidence of ischaemia or infarction. 36 (76.6%) and 18 (38.3%) were seropositive for H pylori and C pneumoniae, respectively, compared with 155 (45.5%) and 62 (18.2%) men with normal electrocardiograms. Odds ratios for abnormal electrocardiograms were 3.82 (95% confidence interval 1.60 to 9.10) and 3.06 (12.33 to 7.01) in men seropositive for H pylori and C pneumoniae, respectively, after adjustment for a range of socioeconomic indicators and risk factors for coronary heart disease. Cardiovascular risk factors that were independently associated with seropositivity to H pylori included fibrinogen concentration and total leucocyte count. Seropositivity to C pneumoniae was independently associated with raised fibrinogen and malondialdehyde concentrations. Conclusions: Both H pylori and C pneumoniae infections are associated with coronary heart disease. These relations are not explained by a wide range of confounding factors. Possible mechanisms include an increase in risk factor levels due to a low grade chronic inflammatory response.

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Authors: Patel, P., Mendall, M. A., Carrington, D., Strachan, D. P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C. A., Camm, A. J., & Northfield, T. C.
Affiliations: St George's, University of London (GB)
ORCID: Patel, P
Strachan, D P
Camm, A J
Venue: BMJ
Publisher: BMJ
Published: 1995-09-16
Volume: 311
Issue: 7007
Pages: 711-714
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.311.7007.711
PMC: PMC2550716
OpenAlex: W1988289155
Cited by: 592
References: 32
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 14 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 12 · 2013: 6 · 2012: 12
FWCI: 54.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: Helicobacter pylori, Chlamydia pneumoniae, coronary artery disease, cardiovascular risk factors, seropositivity, chronic infection, fibrinogen, malondialdehyde, white blood cell count, myocardial infarction, low-grade inflammation, men
MeSH terms: Aged, C-Reactive Protein, Chlamydia Infections, Coronary Disease, Cross-Sectional Studies, Electrocardiography, Fibrinogen, Humans, Leukocyte Count, London, Male, Middle Aged, Risk Factors, Helicobacter pylori, Helicobacter Infections, Chlamydophila pneumoniae

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Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

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