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Cited by 432Oral microbiology and periodontitis researchRheumatoid Arthritis Research and TherapiesPeriodontal Regeneration and Treatments

Relationship Between Rheumatoid Arthritis and Periodontitis

Mercado, F.B., Marshall, R.I., Klestov, A.C., Bartold, P.M.·2001·Journal of Periodontology
DOI 10.1902/jop.2001.72.6.779
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Abstract

Background: Because of several similar features in the pathobiology of periodontitis and rheumatoid arthritis, in a previous study we proposed a possible relationship between the two diseases. Therefore, the aims of this study were to study a population of rheumatoid arthritis patients and determine the extent of their periodontal disease and correlate this with various indicators of rheumatoid arthritis. Methods: Sixty‐five consecutive patients attending a rheumatology clinic were examined for their levels of periodontitis and rheumatoid arthritis. A control group consisted of age‐ and gender‐matched individuals without rheumatoid arthritis. Specific measures for periodontitis included probing depths, attachment loss, bleeding scores, plaque scores, and radiographic bone loss scores. Measures of rheumatoid arthritis included tender joint analysis, swollen joint analysis, pain index, physician's global assessment on a visual analogue scale, health assessment questionnaire, levels of C‐reactive protein, and erythrocyte sedimentation rate. The relationship between periodontal bone loss and rheumatological findings as well as the relationship between bone loss in the rheumatoid arthritis and control groups were analyzed. Results: No differences were noted for the plaque and bleeding indices between the control and rheumatoid arthritis groups. The rheumatoid arthritis group did, however, have more missing teeth than the control group and a higher percentage of these subjects had deeper pocketing. When the percentage of bone loss was compared with various indicators of rheumatoid arthritis disease activity, it was found that swollen joints, health assessment questionnaire scores, levels of C‐reactive protein, and erythrocyte sedimentation rate were the principal parameters which could be associated with periodontal bone loss. Conclusions: The results of this study provide further evidence of a significant association between periodontitis and rheumatoid arthritis. This association may be a reflection of a common underlying disregulation of the inflammatory response in these individuals. J Periodontol 2001;72:779‐787.

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Authors
Mercado, F. B., Marshall, R. I., Klestov, A. C., & Bartold, P. M.
Affiliations
  • The University of Queensland (AU)
  • Royal Brisbane and Women's Hospital (AU)
Corresponding author
Bartold, P.M.
ORCID
Venue
Journal of Periodontology
Publisher
Wiley
Published
2001-06
Volume
72
Issue
6
Pages
779-787
ISSN
  • 0022-3492 (ISSN-L)
  • 1943-3670
DOI
10.1902/jop.2001.72.6.779
OpenAlex
W2013829757
Cited by
432
References
47
Citations by year
2026: 3 · 2025: 4 · 2024: 13 · 2023: 6 · 2022: 9 · 2021: 19 · 2020: 16 · 2019: 22 · 2018: 23 · 2017: 15 · 2016: 30 · 2015: 29 · 2014: 26 · 2013: 30 · 2012: 39
FWCI
10.06
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Periodontology (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
rheumatoid arthritis, periodontitis, periodontal bone loss, disease activity, C-reactive protein, erythrocyte sedimentation rate, inflammation, probing depth, attachment loss, swollen joint count, Health Assessment Questionnaire
MeSH terms
Arthritis, Rheumatoid, Biology, Blood Sedimentation, C-Reactive Protein, Dental Plaque, Dental Plaque Index, Female, Gingival Hemorrhage, Humans, Male, Middle Aged, Pain Measurement, Periodontal Index, Periodontal Pocket, Periodontitis, Radiography, Cohort Studies, Chi-Square Distribution, Logistic Models, Odds Ratio, Case-Control Studies, Alveolar Bone Loss, Tooth Loss, Periodontal Attachment Loss

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