Cited by 295Epilepsy research and treatmentAnesthesia and Sedative AgentsPharmaceutical studies and practices

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Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study

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Lahat, E.·2000·BMJ

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Abstract

OBJECTIVE: To compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of children with prolonged febrile seizures. DESIGN: Prospective randomised study. SETTING: Paediatric emergency department in a general hospital. SUBJECTS: 47 children aged six months to five years with prolonged febrile seizure (at least 10 minutes) during a 12 month period. INTERVENTIONS: Intranasal midazolam (0.2 mg/kg) and intravenous diazepam (0.3 mg/kg). MAIN OUTCOME MEASURES: Time from arrival at hospital to starting treatment and cessation of seizures. RESULTS: Intranasal midazolam and intravenous diazepam were equally effective. Overall, 23 of 26 seizures were controlled with midazolam and 24 out of 26 with diazepam. The mean time from arrival at hospital to starting treatment was significantly shorter in the midazolam group (3.5 (SD 1.8) minutes, 95% confidence interval 3.3 to 3.7) than the diazepam group (5.5 (2.0), 5.3 to 5.7). The mean time to control of seizures was significantly sooner (6.1 (3.6), 6.3 to 6.7) in the midazolam group than the diazepam group (8.0 (0.5), 7. 9 to 8.3). No significant side effects were observed in either group. CONCLUSION: Seizures were controlled more quickly with intravenous diazepam than with intranasal midazolam, although midazolam was as safe and effective as diazepam. The overall time to cessation of seizures after arrival at hospital was faster with intranasal midazolam than with intravenous diazepam. The intranasal route can possibly be used not only in medical centres but in general practice and, with appropriate instructions, by families of children with recurrent febrile seizures at home.

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Protective effect of breast feeding against infection.
Howie, P., Forsyth, J. S., Ogston, S., Clark, A., & Florey, C. D. V. (1990) · BMJ · doi:10.1136/bmj.300.6716.11 · Cited by 877
Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus
(1993) · JAMA · doi:10.1001/jama.270.7.854 · Cited by 471
Midazolam A Review of its Pharmacological Properties and Therapeutic Use
DUNDEE, J. W., Halliday, N. J., Harper, K. W., & Brogden, R. N. (1984) · Drugs · doi:10.2165/00003495-198428060-00002 · Cited by 357
Preanesthetic Sedation of Preschool Children Using Intranasal Midazolam
Wilton, N. C. T., Leigh, J. E., Rosen, D. R., & Pandit, U. A. (1988) · Anesthesiology · doi:10.1097/00000542-198812000-00032 · Cited by 348
A comparison of rectal diazepam gel and placebo for acute repetitive seizures
Dreifuss, F. E., Rosman, N. P., Cloyd, J. C., Pellock, J. M., Kuzniecky, R. I., Lo, W. D., Matsuo, F., Sharp, G. B., Conry, J. A., Bergen, D. C., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806253382602 · Cited by 287
Qualitative study of decisions about infant feeding among women in east end of London
Hoddinott, P., & Pill, R. (1999) · BMJ · doi:10.1136/bmj.318.7175.30 · Cited by 254
A prospective cohort study on breast-feeding and otitis media in Swedish infants
Aniansson, G., Alm, B., ANDERSSON, B., Håkansson, A., LARSSON, P., Nylén, O., PETERSON, H., Rignér, P., Svanborg, M., Sabharwal, H., et al. (1994) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199403000-00003 · Cited by 204
Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry
Mayer, E. J., Hamman, R. F., Gay, E. C., Lezotte, D. C., Savitz, D. A., & KLINGENSMITH, G. J. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1625 · Cited by 187
A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children
Chamberlain, J. M., ALTIERI, M. A., Futterman, C., YOUNG, G. M., Ochsenschlager, D. W., & WAISMAN, Y. (1997) · Pediatric Emergency Care · doi:10.1097/00006565-199704000-00002 · Cited by 178
Breastfeeding and the Risk of Sudden Infant Death Syndrome
Ford, R., Taylor, B. J., Mitchell, E., ENRIGHT, S. A., Stewart, A. W., Becroft, D. M. O., Scragg, R. K. R., Hassall, I. B., BARRY, D. M. J., Allen, E. M., et al. (1993) · International Journal of Epidemiology · doi:10.1093/ije/22.5.885 · Cited by 170

Show all 46 references

Research works printed but not linked: 2

Conner JT, Katz RL, Pagano RP, Graham CW. PO21-3981 for intravenous surgical pre-medication and induction of anesthesia. Anesthesiol Anal 1978;57:1-5.
Lacon A, Reddy VG. Nasal midazolam and ketamine for pediatric seda- tion during computerized tomography. Acta Anesthesiol Scand 1994;38:259-61.

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Pang, T. D., & Hirsch, L. J. (2005) · Current Treatment Options in Neurology · doi:10.1007/s11940-005-0035-x · Cited by 34
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Authors: Lahat, E.
Affiliations: Assaf Harofeh Medical Center (IL)
Corresponding author: Lahat, E.
Venue: BMJ
Publisher: BMJ
Published: 2000-07-08
Volume: 321
Issue: 7253
Pages: 83-86
ISSN: 0959-8138 (ISSN-L)
DOI: 10.1136/bmj.321.7253.83
PMC: PMC27427
OpenAlex: W2059085344
Cited by: 294
References: 46
Citations by year: 2026: 5 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 15 · 2019: 9 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 25 · 2014: 21 · 2013: 13 · 2012: 11
FWCI: 4.65
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: BMJ (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: febrile seizures, prolonged febrile seizures, intranasal midazolam, intravenous diazepam, benzodiazepines, seizure control, pediatric emergency care, time to treatment, children
MeSH terms: Administration, Intranasal, Anticonvulsants, Child, Child, Preschool, Seizures, Febrile, Diazepam, Female, Humans, Infant, Infusions, Intravenous, Male, Midazolam, Prospective Studies, Treatment Outcome

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Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study

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