The DOI matches its Crossref record, with a small difference in title or year; 23 of the 24 references it cites were found in a registry or an index.
Widespread body pain and mortality: prospective population based studyCommentary: An interesting finding, but what does it mean?
Open accessAbstract
Objective: To determine whether there is excess mortality in groups of people who report widespread body pain, and if so to establish the nature and extent of any excess. Design: Prospective follow up study over eight years. Mortality rate ratios were adjusted for age group, sex, and study location. Setting: North west England. Participants: 6569 people who took part in two pain surveys during 1991-2. Main outcome measures: Pain status at baseline and subsequent mortality. Results: 1005 (15%) participants had widespread pain, 3176 (48%) had regional pain, and 2388 (36%) had no pain. During follow up mortality was higher in people with regional pain (mortality rate ratio 1.21, 95% confidence interval 1.01 to 1.44) and widespread pain (1.31, 1.05 to 1.65) than in those who reported no pain. The excess mortality among people with regional and widespread pain was almost entirely related to deaths from cancer (1.55 (1.09 to 2.19) for regional pain and 2.07 (1.37 to 3.13) for widespread pain). The excess cancer mortality remained after exclusion of people in whom cancer had been diagnosed before the original survey and after adjustment for potential confounding factors. There were also more deaths from causes other than disease (for example, accidents, suicide, violence) among people with widespread pain (5.21, 0.94 to 28.78). Conclusion: There is an intriguing association between the report of widespread pain and subsequent death from cancer in the medium and long term. This may have implications for the long term follow up of patients with “unexplained” widespread pain symptoms, such as those with fibromyalgia. What is already known on this topic: Widespread body pain, the cardinal symptom of fibromyalgia, is common An organic basis for symptoms is found in only a small proportion of people Treatment is difficult, and studies with short term follow up have shown that symptoms commonly persist What this study adds: This was the first study with long term follow up of people with widespread pain in the community These people experience an increased mortality and the excess is principally related to deaths from cancer
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“The meaning of pain (i.e. how individuals appraise pain) can be influenced by sociocultural factors and ethnic background 242, 243.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [242]
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Fatigue links sociodemographic risk to pain intensity and spread in 2 surgical cohorts
Sun, M. M. C., Ansari, B., Clauw, D. J., Harris, R. E., Sluka, K. A., Kaplan, C. M., Brummett, C. M., Lindquist, M. A., & Wager, T. D. (2026) · Pain · doi:10.64898/2026.02.02.26345387
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Metadata
- Authors
- Macfarlane, G. J., Crombie, I. K., McBeth, J., & Silman, A. J.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Macfarlane, Gary J
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2001-09-22
- Volume
- 323
- Issue
- 7314
- Pages
- 662
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC55925
- OpenAlex
- W2118879709
- Cited by
- 223
- References
- 24
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 16 · 2013: 11 · 2012: 11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- widespread pain, mortality, cancer mortality, regional pain, fibromyalgia, excess mortality, accidental death, suicide, violence-related deaths, long-term follow-up
- MeSH terms
- Adult, Cause of Death, England, Female, Fibromyalgia, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Prospective Studies, Risk Factors, Survival Rate
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