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Suicide, depression, and antidepressants
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“It has also been considered as a robust predictor of suicidality [10, 11].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [11]
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“First, the absolute numbers of patients with suicidal tendencies were very low, which leaves the possibility that reporting or not reporting a few cases would completely change the overall outcome.(28) In addition, we found disclosure of suicidal tendencies in the GlaxoSmithKline Clinical Trial Registry somewhat probl…”
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“Given the concerns about suicidality in relation to SSRIs (Cipriani et al., 2005) this finding is important in highlighting the need for close monitoring when discontinuing SSRIs and venlafaxine.”
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“This leaves a possibility that even reporting or not reporting a few cases could have completely changed the overall outcome (Cipriani et al.,2005[5]).”
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“Apart from the controversy about the differential risk of suicidality with selective serotonin reuptake inhibitor and with tricyclic agents [47], antidepressant monotherapy may not be the most appropriate option in these cases.”
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“…of increased suicidal ideation following initiation of antidepressant therapy (tricyclics as well as SSRIs) although there is no good evidence that this is translated to an increase in rates of suicide (Cipriani et al., 2005; Fergusson et al, 2005; Gunnell et al, 2005; Martinez et al., 2005).”
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“…be an unfavorable risk to benefit ratio for SSRIs (with fluoxetine as a possible exception) (Bailly, 2008; Barbui et al , 2009; Bridge et al , 2007; Cipriani et al , 2005; Doggrell, 2005; Fergusson et al , 2005; Goodman et al , 2007; Hammad et al , 2006; Laughren, 2006; Mosholder and Willy, 2006;…”
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“They represent alarming psychopathological symptoms, [5] which may lead to deliberate self harm (DSH), suicide attempts and, in up to 10% of cases, to completed suicides [6].”
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“However, severe depression can lead to self-harm or suicide [39].”
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“It is also a strong predictor of suicidal potential 8 and treatment-resistant depression 5 , and stress-induced depression has been clearly related to anhedonia in humans and rodents.”
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“Another study has described that about 15% of individuals with depression eventually commit suicide.(46) Many studies have been conducted on the effect of antidepressants in treating depression and preventing suicide, and completely different results have been extracted.”
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“Formal studies have contributed much more to the drug safety process recently and yet, in the past 5 years, there have been high profile withdrawals of cerivastatin(5) and rofecoxib(6) and other controversial issues such as selective serotonin re-uptake inhibitors and the risk of suicide.(7) These have led to much cri…”
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“It is characterized by low self-esteem, a depressed mood, hopelessness, helplessness, intense feelings of guilt, sadness, and suicidal and self-harming thoughts (11, 12).”
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“However, in the emotional controversy, even after lumping together many RCTs, different articles still gave different estimates ( Cipriani et al. 2005 ).”
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“Therefore, the indication for antidepressants in children should be restricted to those with severe depression who cannot be treated by other means [Cipriani et al., 2005], such as psychotherapy and social support.”
Evidence-based management of stress urinary incontinence
Johnson, H. C., & Slack, M. C. (2005) · The Obstetrician & Gynaecologist · doi:10.1576/toag.2005.7.3.159 · Cited by 1
Commentary on ‘validity of the codes of suicidality in the THIN database’ by Arana et al.
Hall, G. C. (2010) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2056
Gender and Drug Type Linked to Suicidal Thoughts
Yan, J. (2009) · Psychiatric News · doi:10.1176/pn.44.23.psychnews_44_23_030
Relatie tussen gebruik van SSRI’s en zelfmoordpoging
Liem, T. B. Y. (2005) · Medisch-Farmaceutische Mededelingen · doi:10.1007/bf03058658
Raven, M. K. (2005) · BMJ · doi:10.1136/bmj.330.7500.1150-a
“EDITOR—Cipriani et al in their editorial make many sound points about the risks and benefits of antidepressants.”
BackgroundThe Influence of the Health Committee Report
WALLER, P. C. (2005) · International Journal of Pharmaceutical Medicine · doi:10.2165/00124363-200519020-00001
“When considering postmarketing surveillance, the Committee focused on two recently highlighted important safety issues – COX-2 inhibitors and cardiovascular adverse events[3] (erroneously described as “heart failure”) and SSRIs and suicide.[4] Essentially, the Committee heard vocal critics of the regulators who were t…”
BackgroundHatzinger, M. (2007)
Plattner, A., & Dantz, B. (2011) · Psychopharm Review · doi:10.1097/01.idt.0000392937.51742.dc
SSRIs and Suicide Risk: A Concern for Adults, Too?
Roy‐Byrne, P. (2005) · Journal watch · doi:10.1056/jp200503090000001
Do SSRIs Increase Suicide Risk in Adults
Marton, K. I. (2005) · Journal watch · doi:10.1056/jd200504260000010
Myocardial Infarction, Antidepressants and Mortality
Öhman, M. (2016)
Spitzer, C. (2006) · Springer eBooks · doi:10.1007/3-540-28604-7_6
Joel Paris, M. D. (2010) · Wiley eBooks · doi:10.1002/9780470666630.refs
Laux, G. (2008) · Springer eBooks · doi:10.1007/978-3-540-33129-2_55
Metadata
- Authors
- Cipriani, A., Barbui, C., & Geddes, J. R.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Cipriani, Andrea
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-02-17
- Volume
- 330
- Issue
- 7488
- Pages
- 373-374
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC549094
- OpenAlex
- W1972356714
- Cited by
- 102
- References
- 20
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2016: 1 · 2014: 2 · 2013: 5 · 2012: 6
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Sanofi
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- suicide, depression, antidepressants
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Suicide
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