Cited by 454Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

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Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis

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Buscemi, Nina, Vandermeer, Ben, Hooton, Nicola, Pandya, Rena, Tjosvold, Lisa, Hartling, Lisa, Vohra, Sunita, Klassen, Terry P, Baker, Glen·2006·BMJ

DOI 10.1136/bmj.38731.532766.f6PMC PMC1370968

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Abstract

OBJECTIVE: To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. DATA SOURCES: 13 electronic databases and reference lists of relevant reviews and included studies; Associated Professional Sleep Society abstracts (1999 to 2003). STUDY SELECTION: The efficacy review included randomised controlled trials; the safety review included randomised and non-randomised controlled trials. QUALITY ASSESSMENT: Randomised controlled trials were assessed by using the Jadad Scale and criteria by Schulz et al, and non-randomised controlled trials by the Downs and Black checklist. DATA EXTRACTION AND SYNTHESIS: One reviewer extracted data and another reviewer verified the data extracted. The inverse variance method was used to weight studies and the random effects model was used to analyse data. MAIN RESULTS: Six randomised controlled trials with 97 participants showed no evidence that melatonin had an effect on sleep onset latency in people with secondary sleep disorders (weighted mean difference -13.2 (95% confidence interval -27.3 to 0.9) min). Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (-1.0 (-2.3 to 0.3) min). 17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less). CONCLUSIONS: There is no evidence that melatonin is effective in treating secondary sleep disorders or sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. There is evidence that melatonin is safe with short term use.

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Authors: Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G.
Affiliations: University of Alberta (CA)
Corresponding author: Buscemi, Nina
ORCID: Vandermeer, Ben
Tjosvold, Lisa
Hartling, Lisa
Vohra, Sunita
Klassen, Terry P
Baker, Glen
Venue: BMJ
Publisher: BMJ
Published: 2006-02-10
Volume: 332
Issue: 7538
Pages: 385-393
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.38731.532766.f6
PMC: PMC1370968
OpenAlex: W1974254409
Cited by: 454
References: 45
Citations by year: 2026: 1 · 2025: 11 · 2024: 7 · 2023: 20 · 2022: 16 · 2021: 17 · 2020: 20 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 22 · 2015: 25 · 2014: 21 · 2013: 32 · 2012: 36
FWCI: 4.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: U.S. Department of Health and Human Services
Schizophrenia Research Fund
Sick Kids Foundation
University of Alberta
Canada Research Chairs
Hospital for Sick Children
National Institutes of Health
Agency for Healthcare Research and Quality (290-02-0023)
U.S. Public Health Service (290-02-0023)
Health Canada
Canadian Institutes of Health Research
National Center for Complementary and Alternative Medicine
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: exogenous melatonin, sleep restriction, jet lag, sleep latency, adverse effects
MeSH terms: Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Melatonin, Middle Aged, Sleep Wake Disorders, Randomized Controlled Trials as Topic, Treatment Outcome

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Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis

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