Cited by 454Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis

Open access

Buscemi, Nina, Vandermeer, Ben, Hooton, Nicola, Pandya, Rena, Tjosvold, Lisa, Hartling, Lisa, Vohra, Sunita, Klassen, Terry P, Baker, Glen·2006·BMJ

DOI 10.1136/bmj.38731.532766.f6PMC PMC1370968

Open this paper in CoChat — free account Open PDF

Abstract

OBJECTIVE: To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. DATA SOURCES: 13 electronic databases and reference lists of relevant reviews and included studies; Associated Professional Sleep Society abstracts (1999 to 2003). STUDY SELECTION: The efficacy review included randomised controlled trials; the safety review included randomised and non-randomised controlled trials. QUALITY ASSESSMENT: Randomised controlled trials were assessed by using the Jadad Scale and criteria by Schulz et al, and non-randomised controlled trials by the Downs and Black checklist. DATA EXTRACTION AND SYNTHESIS: One reviewer extracted data and another reviewer verified the data extracted. The inverse variance method was used to weight studies and the random effects model was used to analyse data. MAIN RESULTS: Six randomised controlled trials with 97 participants showed no evidence that melatonin had an effect on sleep onset latency in people with secondary sleep disorders (weighted mean difference -13.2 (95% confidence interval -27.3 to 0.9) min). Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (-1.0 (-2.3 to 0.3) min). 17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less). CONCLUSIONS: There is no evidence that melatonin is effective in treating secondary sleep disorders or sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. There is evidence that melatonin is safe with short term use.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/bmj.38731.532766.f6

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.
Downs, S. H., & Black, N. (1998) · Journal of Epidemiology and Community Health · doi:10.1136/jech.52.6.377 · Cited by 8,252
Untitled work
Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634
Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis
Dong, Y., Hao, L., Shi, Z., Wang, G., Zhang, Z., & Han, C. (2013) · Urologia Internationalis · doi:10.1159/000351405 · Cited by 4,557
A Nonparametric “Trim and Fill” Method of Accounting for Publication Bias in Meta-Analysis
Duval, S., & Tweedie, R. (2000) · Journal of the American Statistical Association · doi:10.1080/01621459.2000.10473905 · Cited by 2,955
Meta-analyses involving cross-over trials: methodological issues
Elbourne, D. R., Altman, D. G., Higgins, J. P., Curtin, F., Worthington, H. V., & Vail, A. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.140 · Cited by 2,305

Show all 45 references

Research works printed but not linked: 1

Elbourne DR, Altman DG, Higgins JPT, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials. Int Jt Epidemiolt 2002;31:140-9.

Sorted by citations

European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023
Riemann, D., Espie, C. A., Altena, E., Arnardottir, E. S., Baglioni, C., Bassetti, C. L. A., Bastien, C., Berzina, N., Bjorvatn, B., Dikeos, D., et al. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14035 · Cited by 834
Sleep, insomnia, and depression
Riemann, D. W., Krone, L. B., Wulff, K., & Nissen, C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0411-y · Cited by 901
Melatonin and the ovary: physiological and pathophysiological implications
Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D., Sugino, N., & Reiter, R. J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.016 · Cited by 477
Jet lag: trends and coping strategies
Waterhouse, J. M., Reilly, T., Atkinson, G., & Edwards, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60529-7 · Cited by 442
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders
Auld, F., Maschauer, E. L., Morrison, I., Skene, D. J., & Riha, R. L. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.005 · Cited by 402
Melatonin and its analogs in insomnia and depression
Cardinali, D. P., Srinivasan, V., Brzezinski, A., & Brown, G. M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00962.x · Cited by 360
S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen
Riemann, D. W., Baum, E., Cohrs, S., Crönlein, T., Hajak, G., Hertenstein, E., Klose, P., Langhorst, J., Mayer, G., Nissen, C., et al. (2017) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-016-0097-x · Cited by 354
Medical implications of melatonin: receptor-mediated and receptor-independent actions.
Reiter, R. J., Tan, D. X., Manchester, L. C., Terrón, M. P., Flores, L. J., & Koppisepi, S. (2007) · PubMed · Cited by 331
Tasimelteon for non-24-hour sleep–wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials
Lockley, S. W., Dressman, M. A., Licamele, L., Xiao, C., Fisher, D. M., Flynn‐Evans, E. E., Hull, J. T., Torres, R., Lavedan, C. N., & Polymeropoulos, M. H. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60031-9 · Cited by 294
Melatonin Is Required for the Circadian Regulation of Sleep
Gandhi, A. V., Mosser, E. A., Oikonomou, G., & Prober, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.016 · Cited by 285
Current role of melatonin in pediatric neurology: Clinical recommendations
Bruni, O., Alconada, D. A., Besag, F., Biran, V., Braam, W., Cortese, S., Moavero, R., Parisi, P., Smits, M. G., van der Heijden, K. B., et al. (2014) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2014.12.007 · Cited by 290
The role of melatonin as an antioxidant in the follicle
Tamura, H., Takasaki, A., Taketani, T., Tanabe, M., Kizuka, F., Lee, L., Tamura, I., Maekawa, R., Asada, H., Yamagata, Y., et al. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-5 · Cited by 276
Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial
Bourne, R. S., MILLS, G. H., & Minelli, C. (2008) · Critical Care · doi:10.1186/cc6871 · Cited by 266
Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content
Erland, L. A. E., & Saxena, P. K. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6462 · Cited by 273
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.
van Geijlswijk, I., Korzilius, H., & Smits, M. (2010) · Sleep · doi:10.1093/sleep/33.12.1605 · Cited by 262
A randomized, placebo‐controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities
Wasdell, M. B., Jan, J. E., Bomben, M. M., Fréeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., & Weiss, M. D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00528.x · Cited by 261
A practical approach to circadian rhythm sleep disorders
Bjorvatn, B., & Pallesen, S. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.04.009 · Cited by 233
Long‐term follow‐up of melatonin treatment in children with ADHD and chronic sleep onset insomnia
Hoebert, M., Van Der Heijden, K. B., Van Geijlswijk, I. M., & Smits, M. G. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00681.x · Cited by 220
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial
Gringras, P., Gamble, C. L., Jones, A. P., Wiggs, L. D., Williamson, P. R., Sutcliffe, A. G., Montgomery, P., Whitehouse, W. P., Choonara, I., Allport, T., et al. (2012) · BMJ · doi:10.1136/bmj.e6664 · Cited by 218
Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials
Rajaratnam, S. M. W., Polymeropoulos, M. H., Fisher, D. M., Roth, T. G., Scott, C., Birznieks, G., & Klerman, E. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61812-7 · Cited by 215
A clinical approach to circadian rhythm sleep disorders
Barion, A., & Zee, P. C. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.017 · Cited by 214
New horizons for newborn brain protection: enhancing endogenous neuroprotection
Hassell, K. J., Ezzati, M., Alconada, D. A., Hausenloy, D. J., & Robertson, N. J. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2014-306284 · Cited by 207
The effects of shift work on physical and mental health
Vogel, M., Braungardt, T., Meyer, W. T., & Schneider, W. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0800-4 · Cited by 217
Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial
Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson‐Day, B., Allgar, V. L., Whitton, C., Tomlinson, H., Bennett, S. D., Jardine, J., et al. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1036-5 · Cited by 200
Dietary Factors and Fluctuating Levels of Melatonin
Peuhkuri, K., Sihvola, N., & Korpela, R. (2012) · Food & Nutrition Research · doi:10.3402/fnr.v56i0.17252 · Cited by 194
Melatonin as a free radical scavenger in the ovarian follicle [Review]
Tamura, H., Takasaki, A., Taketani, T., Tanabe, M., Kizuka, F., Lee, L., Tamura, I., Maekawa, R., Asada, H., Yamagata, Y., et al. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0263 · Cited by 194
Is Melatonin the Cornucopia of the 21st Century?
Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M. G., Rizzo, V., Currò, M., Ientile, R., & Caccamo, D. (2020) · Antioxidants · doi:10.3390/antiox9111088 · Cited by 189
Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin
Chang, Y.-S., & Chiang, B. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040462 · Cited by 181
Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials
Gholami, F., Sajjad, M., Rasaei, N., Soveid, N., Setayesh, L., & Mirzaei, K. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10381-w · Cited by 182
Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance
Chang, Y.-S., Lin, M.-H., Lee, J., Lee, P., Dai, Y., Chu, K., Sun, C. H., Lin, Y., Wang, L., Yu, H., et al. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.3092 · Cited by 167
Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action
Srinivasan, V., Pandi-Perumal, S. R., Trahkt, I., Spence, D. W., Pöeggeler, B., Hardeland, R., & Cardinali, D. P. (2009) · International Journal of Neuroscience · doi:10.1080/00207450802328607 · Cited by 162
Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep
Gobbi, G., & Comai, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00087 · Cited by 168
Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders
Keijzer, H., Smits, M. G., Duffy, J. F., & Curfs, L. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.12.001 · Cited by 157
Circadian rhythm sleep disorders in the blind and their treatment with melatonin
Skene, D. J., & Arendt, J. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.013 · Cited by 157
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis
Braam, W., Smits, M. G., Didden, R., Korzilius, H. P. L. M., van Geijlswijk, I. M., & Curfs, L. (2009) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2008.03244.x · Cited by 143
Managing jet lag: Some of the problems and possible new solutions
Arendt, J. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.011 · Cited by 142
The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders
Pandi-Perumal, S. R., Trakht, I., Spence, D. W., Srinivasan, V., Dagan, Y., & Cardinali, D. P. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0847 · Cited by 140
Waterproof paper as a new substrate to construct a disposable sensor for the electrochemical determination of paracetamol and melatonin
Camargo, J. R., Andreotti, I. A. D. A., Kalinke, C., Henrique, J. M., Bonacin, J. A., & Janegitz, B. C. (2019) · Talanta · doi:10.1016/j.talanta.2019.120458 · Cited by 135
A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes
Chen, W. Y., Giobbie-Hurder, A., Gantman, K., Savoie, J., Scheib, R., Parker, L. M., & Schernhammer, E. S. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2944-4 · Cited by 130
The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: A double-blind, placebo-controlled clinical trial
Rondanelli, M., Opizzi, A., Monteferrario, F., Antoniello, N., Manni, R., & Klersy, C. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03232.x · Cited by 126
Sleep Disturbances and Atopic Dermatitis: Relationships, Methods for Assessment, and Therapies
Bawany, F., Northcott, C. A., Beck, L. A., & Pigeon, W. R. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.12.007 · Cited by 142
Biological rhythms and chronotherapeutics in depression
Geoffroy, P. A., & Palagini, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110158 · Cited by 127
Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2Melatonin Receptor Ligand
Ochoa‐Sanchez, R., Comai, S., Lacoste, B., Bambico, F. R., Domínguez-López, S., Spadoni, G., Rivara, S., Bedini, A., Angeloni, D., FRASCHINI, F., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2676-11.2011 · Cited by 128
Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis
Li, T. X., Jiang, S., Han, M., Yang, Z. Z., Lv, J., Deng, C., Reiter, R. J., & Yang, Y. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.004 · Cited by 121
Position statement on pediatric sleep for psychiatrists.
Gruber, R., CARREY, N. J., Weiss, S. K., Frappier, J., Rourke, L. L., Brouillette, R. T., & Wise, M. S. (2014) · Europe PMC (PubMed Central) · Cited by 119
Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis
Campbell, A., Axon, D. R., Martin, J. R., Slack, M. K., Mollon, L. E., & Lee, J. K. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1297-6 · Cited by 119
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work
Liira, J., Verbeek, J. H. A. M., Costa, G., Driscoll, T., Sallinen, M., Isotalo, L. K., & Ruotsalainen, J. H. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009776.pub2 · Cited by 120
Physical Activity as a Predictor of Adolescent Body Fatness
Reichert, F. F., Menezes, A. M. B., Wells, J. C. K., Dumith, S. C., & Hallal, P. C. (2009) · Sports Medicine · doi:10.2165/00007256-200939040-00002 · Cited by 117
Therapeutic application of melatonin in mild cognitive impairment.
Cardinali, D. P., Vigo, D. E., Olivar, N., Vidal, M. F., Furio, A. M., & Brusco, L. I. (2012) · Europe PMC (PubMed Central) · Cited by 116
Review of sleep disorders.
Panossian, L. A., & Avidan, A. (2009) · The Medical clinics of North America · doi:10.1016/j.mcna.2008.09.001 · Cited by 61
Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats
Corrêa, V. L. R., Martins, J. A., de Souza, T. R., Rincon, G. D. C. N., Miguel, M. P., de Menezes, L. B., & Amaral, A. C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.027 · Cited by 113
The prevalence of child maltreatment among Chinese primary and middle school students: a systematic review and meta-analysis
Wang, L., Cheng, H., Qu, Y., Zhang, Y., Cui, Q., & Zou, H. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01916-7 · Cited by 112
Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF ‐1 in a mouse tumor model
Kim, K., Choi, J., Kang, I., Kim, K., Jeong, C., & Jeong, J. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01030.x · Cited by 106
The quality and duration of sleep in the intensive care setting: An integrative review
Elliott, R. M., McKinley, S., & Cistulli, P. A. (2010) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2010.11.006 · Cited by 106
Melatonin for pre- and postoperative anxiety in adults
Hansen, M. V., Halladin, N., Rosenberg, J., Gögenür, I., & Møller, A. M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009861.pub2 · Cited by 106
Potential use of melatonin in sleep and delirium in the critically ill
Bellapart, J., & Boots, R. J. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes035 · Cited by 105
Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma
de Oliveira, E. R., Nascimento, T. L., Salomão, M. A., da Silva, A. C. G., Valadares, M. C., & Lima, E. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2662-z · Cited by 103
Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action
Posadzki, P., Bajpai, R. C., Kyaw, B. M., Roberts, N., Brzezinski, A., Christopoulos, G. I., Divakar, U., Bajpai, S., Soljak, M., Dunleavy, G., et al. (2018) · BMC Medicine · doi:10.1186/s12916-017-1000-8 · Cited by 113
Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study
Garzón, C. E. R., Guerrero, J. M., Aramburu, Ó., & Guzmán, T. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324897 · Cited by 99
Drug Insight: the use of melatonergic agonists for the treatment of insomnia—focus on ramelteon
Pandi-Perumal, S. R., Srinivasan, V., Pöeggeler, B., Hardeland, R., & Cardinali, D. P. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0467 · Cited by 96
Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion
Guenolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.02.001 · Cited by 98
The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).
Appleton, R., Jones, A. P., Gamble, C. L., Williamson, P. R., Wiggs, L. D., Montgomery, P., Sutcliffe, A. G., Barker, C. E., & Gringras, P. (2012) · Health Technology Assessment · doi:10.3310/hta16400 · Cited by 102
Pharmacotherapy of Insomnia
Neubauer, D. N., Pandi-Perumal, S. R., Spence, D. W., Buttoo, K., & Monti, J. M. (2018) · Journal of Central Nervous System Disease · doi:10.1177/1179573518770672 · Cited by 96
Treatment of Circadian Rhythm Sleep–Wake Disorders
Sun, S., & Chen, G. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210907122933 · Cited by 103
Sleep and aging: 2. Management of sleep disorders in older people
Wolkove, N., Elkholy, O., Baltzan, M., & Palayew, M. J. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.070335 · Cited by 110
International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders
Palagini, L., Manni, R., Aguglia, E., Amore, M., Brugnoli, R., Bioulac, S., Bourgin, P., Micoulaud‐Franchi, J., Girardi, P., Grassi, L. G., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.688890 · Cited by 96
Pharmacologic treatment of pediatric insomnia.
Owens, J., & Moturi, S. (2009) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2009.04.009 · Cited by 81
Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials
Chen, S., Shi, L., Liang, F., Xu, L., Doycheva, D. M., Wu, Q., & Zhang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9350-8 · Cited by 87
Melatonin: Countering Chaotic Time Cues
Arendt, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00391 · Cited by 90
Melatonin for preoperative and postoperative anxiety in adults
Madsen, B. K., Zetner, D. B., Møller, A. M., & Rosenberg, J. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009861.pub3 · Cited by 91
Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double‐blind, placebo‐controlled study
Cavalcante, A. G. D. M., de Bruin, P. F. C., de Bruin, V. M. S., Nunes, D. M., Pereira, E. D. B., Cavalcante, M. M., & de Andrade, G. M. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.00992.x · Cited by 84
Complementary and Alternative Medicine in Autism: An Evidence-Based Approach to Negotiating Safe and Efficacious Interventions with Families
Akins, R. S., Angkustsiri, K., & Hansen, R. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.002 · Cited by 83
Melatonin improves quality and longevity of chronic neural recording
Golabchi, A., Wu, B., Li, X., Carlisle, D. L., Kozai, T. D. Y., Friedlander, R. M., & Cui, X. T. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.026 · Cited by 74
Pediatric Sleep Pharmacology
Pelayo, R., & Dubik, M. (2008) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2008.03.004 · Cited by 77
Non–24-Hour Sleep–Wake Rhythm Disorder in Sighted and Blind Patients
Uchiyama, M., & Lockley, S. W. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.006 · Cited by 77
Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates
Carloni, S., Proietti, F., Rocchi, M., Longini, M., Marseglia, L. M., D’Angelo, G., Balduini, W., Gitto, E., & Buonocore, G. (2017) · Molecules · doi:10.3390/molecules22122115 · Cited by 75
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74
The efficacy of melatonin and melatonin agonists in insomnia – An umbrella review
Low, T. L., Choo, F., & Tan, S. M. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.10.022 · Cited by 74
A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood
Serfaty, M. A., Osborne, D., Buszewicz, M., Blizard, R., & Raven, P. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32832c260b · Cited by 74
Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease
Nunes, D. M., Mota, R. M. S., Machado, M. O., Pereira, E. D. B., de Bruin, V. M. S., & de Bruin, P. F. C. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008001000016 · Cited by 74
Melatonin and sleep disorders associated with intellectual disability: a clinical review
Sajith, S. G., & Clarke, D. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00893.x · Cited by 71
Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study
Hartz, I., Skurtveit, S. O., Steffenak, A. K. M., Karlstad, Ø., & Handal, M. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0716-x · Cited by 72
Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases
Socaciu, A. I., Ionuţ, R., SOCACIU, M. A., Ungur, A. P., Bârsan, M., Chiorean, A. R., Socaciu, C., & Râjnoveanu, A. G. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09570-9 · Cited by 73
The Circadian Control of Sleep
Fisher, S. P., Foster, F., & Peirson, S. N. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_7 · Cited by 75
Clinical aspects of melatonin
Reiter, R. J., & Korkmaz, A. (2008) · Saudi Medical Journal · doi:10.15537/1658-3175.4523 · Cited by 68
N -Acetylserotonin
Tosini, G., Ye, K., & Iuvone, P. M. (2012) · The Neuroscientist · doi:10.1177/1073858412446634 · Cited by 65
Control of Sleep and Wakefulness in Health and Disease
Zeitzer, J. M. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00006-3 · Cited by 68
Melatonin as a Neuroprotective Agent in the Rodent Models of Parkinson’s Disease: Is it All Set to Irrefutable Clinical Translation?
Singhal, N. K., Srivastava, G., Agrawal, S., Jain, S. K., & Singh, M. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8225-x · Cited by 65
Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep
Gobbi, G., & Comai, S. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12544 · Cited by 65
Promoting adjustment of the sleep–wake cycle by chronobiotics
Touitou, Y., & Bogdan, A. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.001 · Cited by 64
The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS)
Geoffroy, P. A., Micoulaud‐Franchi, J., Lopez, R., & Schroder, C. M. (2019) · L Encéphale · doi:10.1016/j.encep.2019.04.068 · Cited by 66
Towards rational and evidence‐based use of melatonin in prostate cancer prevention and treatment
Shiu, S. Y. W. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00451.x · Cited by 63
Ramelteon
Simpson, D., & Curran, M. P. (2008) · Drugs · doi:10.2165/00003495-200868130-00011 · Cited by 60
Melatonin versus chloral hydrate for recording sleep EEG
Ashrafi, M. R., Mohammadi, M., Tafaroji, J., Shabanian, R., Salamati, P., & Zamani, G. (2009) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2009.06.010 · Cited by 60
Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study
Robertson, N. J., Martinello, K. A., Lingam, I., Avdic-Belltheus, A., Meehan, C., Alconada, D. A., Ragab, S., Bainbridge, A. P., Sokolska, M., Tachrount, M., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.10.004 · Cited by 60
The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial
Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., Asadi, F., Hekmatdoost, A., Mohammadi, M., & Yari, Z. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102452 · Cited by 60
Pediatric Sleep Pharmacology
Pelayo, R., & Yuen, K. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.08.001 · Cited by 57

Authors: Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G.
Affiliations: University of Alberta (CA)
Corresponding author: Buscemi, Nina
ORCID: Vandermeer, Ben
Tjosvold, Lisa
Hartling, Lisa
Vohra, Sunita
Klassen, Terry P
Baker, Glen
Venue: BMJ
Publisher: BMJ
Published: 2006-02-10
Volume: 332
Issue: 7538
Pages: 385-393
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.38731.532766.f6
PMC: PMC1370968
OpenAlex: W1974254409
Cited by: 454
References: 45
Citations by year: 2026: 1 · 2025: 11 · 2024: 7 · 2023: 20 · 2022: 16 · 2021: 17 · 2020: 20 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 22 · 2015: 25 · 2014: 21 · 2013: 32 · 2012: 36
FWCI: 4.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: U.S. Department of Health and Human Services
Schizophrenia Research Fund
Sick Kids Foundation
University of Alberta
Canada Research Chairs
Hospital for Sick Children
National Institutes of Health
Agency for Healthcare Research and Quality (290-02-0023)
U.S. Public Health Service (290-02-0023)
Health Canada
Canadian Institutes of Health Research
National Center for Complementary and Alternative Medicine
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: exogenous melatonin, sleep restriction, jet lag, sleep latency, adverse effects
MeSH terms: Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Melatonin, Middle Aged, Sleep Wake Disorders, Randomized Controlled Trials as Topic, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks