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Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis
Open accessAbstract
OBJECTIVE: To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. DATA SOURCES: 13 electronic databases and reference lists of relevant reviews and included studies; Associated Professional Sleep Society abstracts (1999 to 2003). STUDY SELECTION: The efficacy review included randomised controlled trials; the safety review included randomised and non-randomised controlled trials. QUALITY ASSESSMENT: Randomised controlled trials were assessed by using the Jadad Scale and criteria by Schulz et al, and non-randomised controlled trials by the Downs and Black checklist. DATA EXTRACTION AND SYNTHESIS: One reviewer extracted data and another reviewer verified the data extracted. The inverse variance method was used to weight studies and the random effects model was used to analyse data. MAIN RESULTS: Six randomised controlled trials with 97 participants showed no evidence that melatonin had an effect on sleep onset latency in people with secondary sleep disorders (weighted mean difference -13.2 (95% confidence interval -27.3 to 0.9) min). Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (-1.0 (-2.3 to 0.3) min). 17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less). CONCLUSIONS: There is no evidence that melatonin is effective in treating secondary sleep disorders or sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. There is evidence that melatonin is safe with short term use.
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“A meta-analysis [289] found essentially no benefit from melatonin.”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [289]
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Metadata
- Authors
- Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Buscemi, Nina
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2006-02-10
- Volume
- 332
- Issue
- 7538
- Pages
- 385-393
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1370968
- OpenAlex
- W1974254409
- Cited by
- 454
- References
- 45
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 7 · 2023: 20 · 2022: 16 · 2021: 17 · 2020: 20 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 22 · 2015: 25 · 2014: 21 · 2013: 32 · 2012: 36
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Schizophrenia Research Fund
- Sick Kids Foundation
- University of Alberta
- Canada Research Chairs
- Hospital for Sick Children
- National Institutes of Health
- Agency for Healthcare Research and Quality (290-02-0023)
- U.S. Public Health Service (290-02-0023)
- Health Canada
- Canadian Institutes of Health Research
- National Center for Complementary and Alternative Medicine
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- exogenous melatonin, sleep restriction, jet lag, sleep latency, adverse effects
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Melatonin, Middle Aged, Sleep Wake Disorders, Randomized Controlled Trials as Topic, Treatment Outcome
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