Cited by 1,353Medication Adherence and CompliancePharmacy and Medical PracticesOpioid Use Disorder Treatment

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A meta-analysis of the association between adherence to drug therapy and mortality

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Simpson, Scot H, Eurich, Dean T, Majumdar, Sumit R, Padwal, Rajdeep S, Tsuyuki, Ross T, Varney, Janice, Johnson, Jeffrey A·2006·BMJ

DOI 10.1136/bmj.38875.675486.55PMC PMC1488752

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Abstract

OBJECTIVE: To evaluate the relation between adherence to drug therapy, including placebo, and mortality. DESIGN: Meta-analysis of observational studies. DATA SOURCES: Electronic databases, contact with investigators, and textbooks and reviews on adherence. Review methods Predefined criteria were used to select studies reporting mortality among participants with good and poor adherence to drug therapy. Data were extracted for disease, drug therapy groups, methods for measurement of adherence rate, definition for good adherence, and mortality. RESULTS: Data were available from 21 studies (46,847 participants), including eight studies with placebo arms (19,633 participants). Compared with poor adherence, good adherence was associated with lower mortality (odds ratio 0.56, 95% confidence interval 0.50 to 0.63). Good adherence to placebo was associated with lower mortality (0.56, 0.43 to 0.74), as was good adherence to beneficial drug therapy (0.55, 0.49 to 0.62). Good adherence to harmful drug therapy was associated with increased mortality (2.90, 1.04 to 8.11). CONCLUSION: Good adherence to drug therapy is associated with positive health outcomes. Moreover, the observed association between good adherence to placebo and mortality supports the existence of the "healthy adherer" effect, whereby adherence to drug therapy may be a surrogate marker for overall healthy behaviour.

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“…do not fully reflect the complete range of pulmonary TB treatment, which includes medication-taking behavior and lifestyle changes, as revealed by studies (Burusie et al., 2020; Krapp et al., 2008; Samuel et al., 2016; Simpson et al., 2006; Srisurad & Phetphum, 2021; Weiangkham et al., 2022).”
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“In a meta-analysis including 21 studies and 46,847 patients, Simpson et al studied the association between adherence to medications and death.(5) Odds ratio for good vs poor adherence was 0.”
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A Biocompatible Liquid Pillar[n]arene-Based Drug Reservoir for Topical Drug Delivery
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A case report: Management of carbamazepine intoxication using hemodialysis followed by continuous venovenous hemodialysis
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“8,9 Pharmacobezoars occur when many tablets are ingested in a short period of time, combined with a lack of fluid for the tablets to dissolve as well as hypomotility of the GI tract caused by the anticho-linergic effects of CBZ.”
Influential factors of adherence to inhalation drug therapy in patients with stable chronic obstructive pulmonary disease
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An update on telmisartan/hydrochlorothiazide combinations for the management of hypertensive patients with additional cardiovascular risk factors
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Polypill" conception in modern cardiology
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“Many studies regard patient adherence to be a preventive factor of clinical outcomes,(4,7) and consider non-adherence to be a risk factor.(4) In addition, several studies have assessed interventions to strengthen patient adherence,(8,9) including home-based healthcare services,(10) health education,(11) shared decisio…”
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Wie Forschung das Therapieren noch effektiver machen kann
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“This is worrying because a better estimation of neonatal risk could lead to better information for parents, and appropriate information is likely to improve compliance, therapeutic compliance, and positive health outcomes [22].”
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The Impact of Lost Therapeutic Benefit ( LTB ) in High‐Risk Hypertensive Patients: 2‐Year Follow‐Up Data from the Australian REACH Registry
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Authors: Simpson, S. H., Eurich, D. T., Majumdar, S. R., Padwal, R. S., Tsuyuki, R. T., Varney, J., & Johnson, J. A.
Affiliations: University of Alberta (CA)
Institute of Health Economics (CA)
Corresponding author: Simpson, Scot H
ORCID: Simpson, Scot H
Eurich, Dean T
Majumdar, Sumit R
Tsuyuki, Ross T
Johnson, Jeffrey A
Venue: BMJ
Publisher: BMJ
Published: 2006-06-21
Volume: 333
Issue: 7557
Pages: 15
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.38875.675486.55
PMC: PMC1488752
OpenAlex: W2147982456
Cited by: 1,353
References: 39
Citations by year: 2026: 37 · 2025: 40 · 2024: 57 · 2023: 56 · 2022: 55 · 2021: 83 · 2020: 55 · 2019: 74 · 2018: 90 · 2017: 91 · 2016: 69 · 2015: 71 · 2014: 83 · 2013: 77 · 2012: 86
FWCI: 8.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: medication adherence, pharmacotherapy, mortality, adherence measurement methods
MeSH terms: Drug Therapy, Epidemiologic Methods, Humans, Patient Compliance, Prognosis, Randomized Controlled Trials as Topic

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A meta-analysis of the association between adherence to drug therapy and mortality

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