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Cited by 1,353Medication Adherence and CompliancePharmacy and Medical PracticesOpioid Use Disorder Treatment

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

A meta-analysis of the association between adherence to drug therapy and mortality

Open access
Simpson, Scot H, Eurich, Dean T, Majumdar, Sumit R, Padwal, Rajdeep S, Tsuyuki, Ross T, Varney, Janice, Johnson, Jeffrey A·2006·BMJ
DOI 10.1136/bmj.38875.675486.55PMC PMC1488752
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Abstract

OBJECTIVE: To evaluate the relation between adherence to drug therapy, including placebo, and mortality. DESIGN: Meta-analysis of observational studies. DATA SOURCES: Electronic databases, contact with investigators, and textbooks and reviews on adherence. Review methods Predefined criteria were used to select studies reporting mortality among participants with good and poor adherence to drug therapy. Data were extracted for disease, drug therapy groups, methods for measurement of adherence rate, definition for good adherence, and mortality. RESULTS: Data were available from 21 studies (46,847 participants), including eight studies with placebo arms (19,633 participants). Compared with poor adherence, good adherence was associated with lower mortality (odds ratio 0.56, 95% confidence interval 0.50 to 0.63). Good adherence to placebo was associated with lower mortality (0.56, 0.43 to 0.74), as was good adherence to beneficial drug therapy (0.55, 0.49 to 0.62). Good adherence to harmful drug therapy was associated with increased mortality (2.90, 1.04 to 8.11). CONCLUSION: Good adherence to drug therapy is associated with positive health outcomes. Moreover, the observed association between good adherence to placebo and mortality supports the existence of the "healthy adherer" effect, whereby adherence to drug therapy may be a surrogate marker for overall healthy behaviour.

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  1. Tobias A. Assessing the influences of a single study in meta-analysis. Stata Tech Bull 1999;47:15-7.

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Metadata

Authors
Simpson, S. H., Eurich, D. T., Majumdar, S. R., Padwal, R. S., Tsuyuki, R. T., Varney, J., & Johnson, J. A.
Affiliations
  • University of Alberta (CA)
  • Institute of Health Economics (CA)
Corresponding author
Simpson, Scot H
ORCID
Venue
BMJ
Publisher
BMJ
Published
2006-06-21
Volume
333
Issue
7557
Pages
15
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.38875.675486.55
PMC
PMC1488752
OpenAlex
W2147982456
Cited by
1,353
References
39
Citations by year
2026: 37 · 2025: 40 · 2024: 57 · 2023: 56 · 2022: 55 · 2021: 83 · 2020: 55 · 2019: 74 · 2018: 90 · 2017: 91 · 2016: 69 · 2015: 71 · 2014: 83 · 2013: 77 · 2012: 86
FWCI
8.08
Type
journal article
Language
en
Open access
Licence
www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
medication adherence, pharmacotherapy, mortality, adherence measurement methods
MeSH terms
Drug Therapy, Epidemiologic Methods, Humans, Patient Compliance, Prognosis, Randomized Controlled Trials as Topic

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