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Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial
Open accessAbstract
OBJECTIVE: To determine whether a combination of a selective serotonin reuptake inhibitor (SSRIs) and cognitive behaviour therapy (CBT) together with clinical care is more effective in the short term than an SSRI and clinical care alone in adolescents with moderate to severe major depression. DESIGN: Pragmatic randomised controlled superiority trial. SETTING: 6 outpatient clinics in Manchester and Cambridge. PARTICIPANTS: 208 adolescents, aged 11-17, with moderate to severe major or probable major depression who had not responded to a brief initial intervention. Adolescents with suicidality, depressive psychosis, or conduct disorder were included. INTERVENTIONS: 103 adolescents received an SSRI and routine care; 105 received an SSRI, routine care, and CBT. The trial lasted 12 weeks, followed by a 16 week maintenance phase. MAIN OUTCOME MEASURES: Change in score on the Health of the Nation outcome scales for children and adolescents (primary outcome) from baseline with 12 weeks as the primary and 28 weeks as the follow-up end point. Secondary measures were change in scores on the mood and feelings questionnaire, the revised children's depression rating scale, the children's global assessment scale, and the clinical global impression improvement scale. RESULTS: At 12 weeks the treatment effect for the primary outcome was -0.64 (95% confidence interval -2.54 to 1.26, P=0.50). In a longitudinal analysis, there was no difference in effectiveness of treatment for the primary (average treatment effect 0.001, -1.52 to 1.52, P=0.99) or secondary outcome measures. On average there was a decrease in suicidal thoughts and self harm. There was no evidence of a protective effect of cognitive behaviour therapy on suicidal thinking or action. By 28 weeks, 57% were much or very much improved with 20% remaining unimproved. CONCLUSIONS: For adolescents with moderate to severe major depression there is no evidence that the combination of CBT plus an SSRI in the presence of routine clinical care contributes to an improved outcome by 28 weeks compared with the provision of routine clinical care plus an SSRI alone. TRIAL REGISTRATION: Current Controlled Trials ISRCNT 83809224.
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“a large study showing that 21% of moderate to severely depressed adolescents improved with a brief psychosocial intervention before being randomised between medication and treatment as usual.7”
From Computerised cognitive behaviour therapy for depression in adolescents: Study protocol for a feasibility randomised controlled trial (2014) · cites this paper as [7]
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“However, some studies have questioned its efficacy in young people with moderate to severe depression, questioning how powerful a treatment it is.7 11”
From Computerised cognitive behaviour therapy for depression in adolescents: Study protocol for a feasibility randomised controlled trial (2014) · cites this paper as [7]
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KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
(1976) · Medical Entomology and Zoology · Cited by 8,899
Everitt, B. S. (2001) · Psychology Press eBooks · doi:10.4324/9781410605542-11 · Cited by 6,877
Analysis of Longitudinal Data.
Have, T. R. T., Diggle, P. J., Liang, K., & Zeger, S. L. (1995) · Journal of the American Statistical Association · doi:10.2307/2291352 · Cited by 1,171
Whittington, C. J., Kendall, T., Fonagy, P., Cottrell, D., Cotgrove, A., & Boddington, E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16043-1 · Cited by 1,006
The National Collaborating Centre for Mental Health
Kendall, T., & Pilling, S. (2004) · UCL Discovery (University College London) · Cited by 840
Preliminary Studies of the Reliability and Validity of the Children's Depression Rating Scale
Poznanski, E. O., GROSSMAN, J. A., BUCHSBAUM, Y. Y., Banegas, M., FREEMAN, L., & Gibbons, R. D. (1984) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198403000-00011 · Cited by 601
Wood, A., Kroll, L., Moore, A., & Harrington, R. (1995) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1995.tb01828.x · Cited by 430
Self-citationCurry, J. F., Rohde, P., Simons, A. D., Silva, S. G., Vitiello, B., Kratochvil, C. J., Reinecke, M. A., Feeny, N. C., Wells, K., Pathak, S., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000240838.78984.e2 · Cited by 429
Research works printed but not linked: 1
- Wood A, Kroll L, Moore A, Harrington RC. Properties of the mood and feelings questionnaire: a research note. J Child Adolesc Psychol Psychiatry 1995;36:298-302.
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Coghill, D. (2020) · Mental health and illness worldwide · doi:10.1007/978-981-10-2348-4_47 · Cited by 1
Depression in Different Types of Patients
Friedman, E. S., & Anderson, I. M. (2014) · doi:10.1007/978-1-907673-79-5_2 · Cited by 1
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Study was not a trial of antidepressants
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Current awareness in human psychopharmacology
(2008) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.888 · Cited by 1
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Pharmacotherapy for Pediatric Major Depression
Tao, R., Emslie, G. J., & Mayes, T. L. (2010) · Psychiatric Annals · doi:10.3928/00485713-20100330-08
Cognitive behavioral treatment of depression in youth.
Mahoney, J. R., Kennard, B., & Mayes, T. (2011) · Pediatric annals · doi:10.3928/00904481-20110512-06 · Cited by 1
Collins, H. E. (2010) · Figshare · doi:10.25959/23208680
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Aspectos psiconeuroinmunológicos del Síndrome de Chediak-Higashi: Articulo de revisión.
Rodríguez, T. E. M. (2008) · Psiquiatria.com
Combined Therapy for Adolescents with Depression
Geller, B. (2007) · Journal watch · doi:10.1056/jp200707200000001
Albieri, E. (2014) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/6405
Managing depression in childhood and adolescence
Wilkinson, P. O. (2009) · London Journal of Primary Care · doi:10.1080/17571472.2009.11493236
Self-citationThe feasibility of a randomised controlled trial of
Turner‐Halliday, F., Watson, N., Boyer, N., Boyd, K., & Minnis, H. (2014)
Psychodynamic child psychotherapy
Fonagy, P., & Target, M. (2012) · doi:10.1093/med/9780199696758.003.0233
Chapter 4. Combined CBT and Psychopharmacology
Singh, S., Lewis, L. R., Rabinovitch, A. E., Caraballo, A. A., D, M. A. M., & Rynn, M. A. (2012) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615370955.es04
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Cook, R. M. (2016) · OhioLink ETD Center (Ohio Library and Information Network)
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Mehler‐Wex, C. (2008) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2008.0364
Les jugements de contingence chez les individus dépressifs et non dépressifs : une méta-analyse
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Depressive Disorders in Children and Adolescents: What Every School Counselor Needs to Know
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Lincke, L., & Kölch, M. G. (2021) · Kinder- und Jugendmedizin · doi:10.1055/a-1404-6527
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Fadıloğlu, E., Subaşı, E. A., Budak, B. Y., Kuşçu, T. D., Bilim, G. Ö., Gündüz, B. U., Budagova, G., Tarakçıoğlu, M. F., & Yıldırım, F. (2021) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.44
(2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283130fb7
Stallard, P. N. (2020) · Wiley eBooks · doi:10.1002/9781119396307.refs
Eggers, C. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_17
Kaminska, N., Oppetit, A., Gallien, M., Vachez-Gatecel, A., Aouidad, A., & Cohen, D. (2022) · Neuropsychiatrie de l Enfance et de l Adolescence · doi:10.1016/j.neurenf.2022.01.005
Jain, S. B. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.14267300.15779493
(2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373679-6.00020-7
Rayapati, A. O., Venugopalakrishnan, J., Gandham, L., Kanga, F. H., & Martin, C. A. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5999-6_196
Goodman, R., & Scott, S. (2012) · doi:10.1002/9781118340899.ch10
Depression in different types of patients
Denko, T., & Friedman, E. S. (2009) · doi:10.1007/978-1-907673-24-5_2
Mental Health and the Youth Athlete: An Analysis of the HeartBytes Database
Vyas, A. J., Sun, M., Farber, J., Dikdan, S. J., Ruge, M., Corgan, S., Johnson, D., & Shipon, D. (2024) · Journal of Orthopaedics and Sports Medicine · doi:10.26502/josm.511500153
Marchant, A. L., McGregor, J., DelPozo‐Baños, M., Lloyd, K. R., Williams, D., Thapar, A., Watkins, A., & John, A. M. (2024) · Psychological Medicine · doi:10.1017/s0033291724002861
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Plener, P. L. (2014) · Springer eBooks · doi:10.1007/978-3-662-44338-5_6
Messina, L. A. (2015) · University Libraries (University of Maryland) · doi:10.13016/m2933m
Metadata
- Authors
- Goodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., Byford, S., Breen, S., Ford, C., Barrett, B., Leech, A., Rothwell, J., White, L., & Harrington, R.
- Affiliations
- University of Cambridge (GB)
- University of Manchester (GB)
- University of Sheffield (GB)
- Fulbourn Hospital (GB)
- Corresponding author
- Goodyer, Ian
- ORCID
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2007-06-07
- Volume
- 335
- Issue
- 7611
- Pages
- 142
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1925185
- OpenAlex
- W2057515552
- Cited by
- 352
- References
- 28
- Citations by year
- 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 14 · 2020: 9 · 2019: 10 · 2018: 15 · 2017: 8 · 2016: 23 · 2015: 19 · 2014: 27 · 2013: 26 · 2012: 38
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- selective serotonin reuptake inhibitors, cognitive behavioral therapy, adolescent depression, major depressive disorder, combination therapy, routine clinical practice, treatment effectiveness, suicidal ideation, self-harm, maintenance phase
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Combined Modality Therapy, Depressive Disorder, Female, Humans, Male, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors
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