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Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial
Open accessAbstract
OBJECTIVE: To determine whether a combination of a selective serotonin reuptake inhibitor (SSRIs) and cognitive behaviour therapy (CBT) together with clinical care is more effective in the short term than an SSRI and clinical care alone in adolescents with moderate to severe major depression. DESIGN: Pragmatic randomised controlled superiority trial. SETTING: 6 outpatient clinics in Manchester and Cambridge. PARTICIPANTS: 208 adolescents, aged 11-17, with moderate to severe major or probable major depression who had not responded to a brief initial intervention. Adolescents with suicidality, depressive psychosis, or conduct disorder were included. INTERVENTIONS: 103 adolescents received an SSRI and routine care; 105 received an SSRI, routine care, and CBT. The trial lasted 12 weeks, followed by a 16 week maintenance phase. MAIN OUTCOME MEASURES: Change in score on the Health of the Nation outcome scales for children and adolescents (primary outcome) from baseline with 12 weeks as the primary and 28 weeks as the follow-up end point. Secondary measures were change in scores on the mood and feelings questionnaire, the revised children's depression rating scale, the children's global assessment scale, and the clinical global impression improvement scale. RESULTS: At 12 weeks the treatment effect for the primary outcome was -0.64 (95% confidence interval -2.54 to 1.26, P=0.50). In a longitudinal analysis, there was no difference in effectiveness of treatment for the primary (average treatment effect 0.001, -1.52 to 1.52, P=0.99) or secondary outcome measures. On average there was a decrease in suicidal thoughts and self harm. There was no evidence of a protective effect of cognitive behaviour therapy on suicidal thinking or action. By 28 weeks, 57% were much or very much improved with 20% remaining unimproved. CONCLUSIONS: For adolescents with moderate to severe major depression there is no evidence that the combination of CBT plus an SSRI in the presence of routine clinical care contributes to an improved outcome by 28 weeks compared with the provision of routine clinical care plus an SSRI alone. TRIAL REGISTRATION: Current Controlled Trials ISRCNT 83809224.
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“a large study showing that 21% of moderate to severely depressed adolescents improved with a brief psychosocial intervention before being randomised between medication and treatment as usual.7”
From Computerised cognitive behaviour therapy for depression in adolescents: Study protocol for a feasibility randomised controlled trial (2014) · cites this paper as [7]
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“However, some studies have questioned its efficacy in young people with moderate to severe depression, questioning how powerful a treatment it is.7 11”
From Computerised cognitive behaviour therapy for depression in adolescents: Study protocol for a feasibility randomised controlled trial (2014) · cites this paper as [7]
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KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
(1976) · Medical Entomology and Zoology · Cited by 8,899
Everitt, B. S. (2001) · Psychology Press eBooks · doi:10.4324/9781410605542-11 · Cited by 6,877
Analysis of Longitudinal Data.
Have, T. R. T., Diggle, P. J., Liang, K., & Zeger, S. L. (1995) · Journal of the American Statistical Association · doi:10.2307/2291352 · Cited by 1,171
Whittington, C. J., Kendall, T., Fonagy, P., Cottrell, D., Cotgrove, A., & Boddington, E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16043-1 · Cited by 1,006
The National Collaborating Centre for Mental Health
Kendall, T., & Pilling, S. (2004) · UCL Discovery (University College London) · Cited by 840
Preliminary Studies of the Reliability and Validity of the Children's Depression Rating Scale
Poznanski, E. O., GROSSMAN, J. A., BUCHSBAUM, Y. Y., Banegas, M., FREEMAN, L., & Gibbons, R. D. (1984) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198403000-00011 · Cited by 601
Wood, A., Kroll, L., Moore, A., & Harrington, R. (1995) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1995.tb01828.x · Cited by 430
Self-citationCurry, J. F., Rohde, P., Simons, A. D., Silva, S. G., Vitiello, B., Kratochvil, C. J., Reinecke, M. A., Feeny, N. C., Wells, K., Pathak, S., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000240838.78984.e2 · Cited by 429
Research works printed but not linked: 1
- Wood A, Kroll L, Moore A, Harrington RC. Properties of the mood and feelings questionnaire: a research note. J Child Adolesc Psychol Psychiatry 1995;36:298-302.
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Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60871-4 · Cited by 2,365
Self-harm and suicide in adolescents
Hawton, K., Saunders, K. E., & O'Connor, R. C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60322-5 · Cited by 2,306
Hawton, K., & van Heeringen, K. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60372-x · Cited by 1,671
Birmaher, B., & Brent, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318145ae1c · Cited by 1,056
Anderson, I. M., Ferrier, I. N., Baldwin, R., Cowen, P. J., Howard, L. M., Lewis, G., Matthews, K., McAllister-Williams, H., Peveler, R. C., Scott, J. L., et al. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088441 · Cited by 909
Metadata
- Authors
- Goodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., Byford, S., Breen, S., Ford, C., Barrett, B., Leech, A., Rothwell, J., White, L., & Harrington, R.
- Affiliations
- University of Cambridge (GB)
- University of Manchester (GB)
- University of Sheffield (GB)
- Fulbourn Hospital (GB)
- Corresponding author
- Goodyer, Ian
- ORCID
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2007-06-07
- Volume
- 335
- Issue
- 7611
- Pages
- 142
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1925185
- OpenAlex
- W2057515552
- Cited by
- 352
- References
- 28
- Citations by year
- 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 14 · 2020: 9 · 2019: 10 · 2018: 15 · 2017: 8 · 2016: 23 · 2015: 19 · 2014: 27 · 2013: 26 · 2012: 38
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- selective serotonin reuptake inhibitors, cognitive behavioral therapy, adolescent depression, major depressive disorder, combination therapy, routine clinical practice, treatment effectiveness, suicidal ideation, self-harm, maintenance phase
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Combined Modality Therapy, Depressive Disorder, Female, Humans, Male, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors
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