Benign and malignant breast disease in south Wales: a study of urinary steroids.
Open accessAbstract
The levels of aetiocholanolone, androsterone, and 17-hydroxycorticosteroids were measured in women without known disease of the breast, in women with benign breast disease, and in women with primary and advanced breast cancer. Statistical analysis showed there was no difference in the excretion of urinary 17-hydroxycorticosteroids in the various groups of patients. Detailed analysis of the aetiocholanolone and androsterone levels, however, indicated that patients with advanced localized disease excreted significantly less of these 11-deoxy-17-oxosteroids than those in the other groups.
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Women with breast cancer were found to have low urinary levels of androsterone and etiocholanolone, two metabolites of DHEA.
“women with breast cancer were found to have low urinary levels of androsterone and etiocholanolone, two metabolites of DHEA (283, 284).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [284]
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Cites
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- Authors
- Cameron, E. H. D., Griffiths, K., Gleave, E. N., Stewart, H. J., Forrest, A. P. M., & Campbell, H.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1970-12-26
- Volume
- 4
- Issue
- 5738
- Pages
- 768-771
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1820362
- OpenAlex
- W2055271651
- Cited by
- 38
- References
- 8
- Citations by year
- 2025: 1
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Tenovus
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- benign breast disease, breast cancer, urinary steroids, aetiocholanolone, androsterone, 17-hydroxycorticosteroids, advanced breast cancer
- MeSH terms
- Adult, Androsterone, Breast Diseases, Breast Neoplasms, Chromatography, Gas, Chromatography, Paper, Dehydroepiandrosterone, Etiocholanolone, Female, Humans, Middle Aged, Wales, 17-Hydroxycorticosteroids, 17-Ketosteroids
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