Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat.
Abstract
The concentration of serum dehydroepiandrosterone sulfate (DHEA-S) and DHEA decreases markedly during aging, and low circulating levels of DHEA have been associated with a higher incidence of breast cancer in women. Using 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat as model, we have studied the effect of increasing serum levels of DHEA released from Silastic implants on the incidence of these tumors in the rat. Treatment with increasing doses of DHEA leading to serum DHEA levels comparable to those observed in normal adult women (7.1 +/- 0.6 nM and 17.5 +/- 1.1 nM) caused a progressive inhibition of tumor development from 68% bearing tumors in control animals to 22% and 11%, respectively. The average tumor area per rat decreased from 2.81 cm2 in intact control animals to 0.96 and 0.09 cm2 in the groups treated with the same doses of DHEA, respectively. The present data indicate that circulating levels of DHEA similar to those found in normal adult premenopausal women exert a potent inhibitory effect on the development of DMBA-induced mammary tumors in the rat, thus suggesting the possibility of a new and more physiological approach for the prevention of breast cancer in women.
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Treatment with increasing doses of DHEA delivered constantly by implants caused progressive inhibition of tumor development in DMBA-induced rat mammary carcinoma.
“Treatment with increasing doses of DHEA delivered constantly by SILASTIC-brand implants of increasing length and number caused a progressive inhibition of tumor development (258).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [258]
A series of studies in experimental animals have shown anticarcinogenic activity of DHEA.
“A series of studies performed in experimental animals have shown the anticarcinogenic activity of DHEA (258, 286, 287).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [258]
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Self-citation
- Authors
- Li, S., Yan, X., B�langer, A., & Labrie, F.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Venue
- Breast Cancer Research and Treatment
- Published
- 1994
- Volume
- 29
- Issue
- 2
- Pages
- 203-217
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2025785620
- Cited by
- 70
- References
- 55
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2014: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- dehydroepiandrosterone, breast cancer prevention, 7,12-dimethylbenz(a)anthracene, DMBA-induced mammary tumors, dehydroepiandrosterone sulfate, tumor suppression, silastic implants, premenopausal women
- MeSH terms
- Animals, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Drug Implants, Female, Luteinizing Hormone, Mammary Neoplasms, Experimental, Ovariectomy, Prolactin, Time Factors, 9,10-Dimethyl-1,2-benzanthracene, Anticarcinogenic Agents, Rats, Sprague-Dawley, Dehydroepiandrosterone Sulfate, Rats
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