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Cited by 358Gestational Diabetes Research and ManagementDiabetes Management and ResearchPregnancy and Medication Impact

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial

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Murphy, H. R, Rayman, G., Lewis, K., Kelly, S., Johal, B., Duffield, K., Fowler, D., Campbell, P. J, Temple, R. C·2008·BMJ
DOI 10.1136/bmj.a1680PMC PMC2563261
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Abstract

OBJECTIVE: To evaluate the effectiveness of continuous glucose monitoring during pregnancy on maternal glycaemic control, infant birth weight, and risk of macrosomia in women with type 1 and type 2 diabetes. DESIGN: Prospective, open label randomised controlled trial. SETTING: Two secondary care multidisciplinary obstetric clinics for diabetes in the United Kingdom. PARTICIPANTS: 71 women with type 1 diabetes (n=46) or type 2 diabetes (n=25) allocated to antenatal care plus continuous glucose monitoring (n=38) or to standard antenatal care (n=33). INTERVENTION: Continuous glucose monitoring was used as an educational tool to inform shared decision making and future therapeutic changes at intervals of 4-6 weeks during pregnancy. All other aspects of antenatal care were equal between the groups. MAIN OUTCOME MEASURES: The primary outcome was maternal glycaemic control during the second and third trimesters from measurements of HbA(1c) levels every four weeks. Secondary outcomes were birth weight and risk of macrosomia using birthweight standard deviation scores and customised birthweight centiles. Statistical analyses were done on an intention to treat basis. RESULTS: Women randomised to continuous glucose monitoring had lower mean HbA(1c) levels from 32 to 36 weeks' gestation compared with women randomised to standard antenatal care: 5.8% (SD 0.6) v 6.4% (SD 0.7). Compared with infants of mothers in the control arm those of mothers in the intervention arm had decreased mean birthweight standard deviation scores (0.9 v 1.6; effect size 0.7 SD, 95% confidence interval 0.0 to 1.3), decreased median customised birthweight centiles (69% v 93%), and a reduced risk of macrosomia (odds ratio 0.36, 95% confidence interval 0.13 to 0.98). CONCLUSION: Continuous glucose monitoring during pregnancy is associated with improved glycaemic control in the third trimester, lower birth weight, and reduced risk of macrosomia. TRIAL REGISTRATION: Current Controlled Trials ISRCTN84461581.

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Fig 1 Progression of women through trial
Fig 1 Progression of women through trialCC BY · PubMed Central
Fig 2 Mean HbA1c levels every four weeks in women receiving standard antenatal care (n=33) or antenatal care plus continuous glucose monitoring (n=38). Vertical lines are standard deviation at each time point
Fig 2 Mean HbA1c levels every four weeks in women receiving standard antenatal care (n=33) or antenatal care plus continuous glucose monitoring (n=38). Vertical lines are standard deviation at each time pointCC BY · PubMed Central
Fig 3 Distribution of birthweight standard deviation scores for 62 healthy living singletons of mothers in continuous glucose monitoring arm (n=32) or standard antenatal care arm (n=30). *Infants of mothers who withdrew from intervention arm (included in intention to treat analysis). Thick lines indicate medians and thin lines interquartile ranges
Fig 3 Distribution of birthweight standard deviation scores for 62 healthy living singletons of mothers in continuous glucose monitoring arm (n=32) or standard antenatal care arm (n=30). *Infants of mothers who withdrew from intervention arm (included in intention to treat analysis). Thick lines indicate medians and thin lines interquartile rangesCC BY · PubMed Central

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Research works printed but not linked: 1

  1. [10]Van Assche FA, Holemans K, Aerts L. Fetal growth and consequences for later life. J Perinat Med 1998; 26: 337-46. 10027128

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Metadata

Authors
Murphy, H. R., Rayman, G., Lewis, K., Kelly, S., Johal, B., Duffield, K., Fowler, D., Campbell, P. J., & Temple, R. C.
Affiliations
  • National Health Service (GB)
  • Ipswich Hospital (GB)
  • Norfolk and Norwich University Hospital (GB)
  • Wellcome Sanger Institute (GB)
Corresponding author
Murphy, H. R
ORCID
Venue
BMJ
Publisher
BMJ
Published
2008-09-25
Volume
337
Issue
sep25 2
Pages
a1680-a1680
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.a1680
PMC
PMC2563261
OpenAlex
W2084809043
Cited by
358
References
39
Citations by year
2026: 10 · 2025: 20 · 2024: 16 · 2023: 21 · 2022: 13 · 2021: 26 · 2020: 15 · 2019: 21 · 2018: 28 · 2017: 16 · 2016: 24 · 2015: 16 · 2014: 14 · 2013: 24 · 2012: 24
FWCI
26.85
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMJ (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion, cc-by)
Funders
Diabetes UK
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
continuous glucose monitoring, pregnancy, type 1 diabetes, type 2 diabetes, maternal glycaemic control, HbA1c, birth weight, macrosomia, prenatal care, shared decision-making, gestational diabetes mellitus
MeSH terms
Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Fetal Macrosomia, Glycated Hemoglobin, Humans, Hyperglycemia, Middle Aged, Pregnancy, Pregnancy in Diabetics, Pregnancy Outcome, Prenatal Care, Prenatal Diagnosis, Prospective Studies, Time Factors, Blood Glucose Self-Monitoring

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